CO5640084A2 - Ligandos de receptores cannabinoides y sus usos - Google Patents

Ligandos de receptores cannabinoides y sus usos

Info

Publication number
CO5640084A2
CO5640084A2 CO05106974A CO05106974A CO5640084A2 CO 5640084 A2 CO5640084 A2 CO 5640084A2 CO 05106974 A CO05106974 A CO 05106974A CO 05106974 A CO05106974 A CO 05106974A CO 5640084 A2 CO5640084 A2 CO 5640084A2
Authority
CO
Colombia
Prior art keywords
alkyl
substituents
optionally substituted
compound
heteroaryl
Prior art date
Application number
CO05106974A
Other languages
English (en)
Inventor
Philip Albert Carpino
Robert Lee Dow
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5640084A2 publication Critical patent/CO5640084A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1.- Un compuesto de fórmula (I) o (II)en la que A es nitrógeno y B es carbono, o A es carbono y B es nitrógeno;R0 es un arilo opcionalmente sustituido con uno o más sustituyentes, o un heteroarilo opcionalmente sustituido con uno o más sustituyentes;R1 es arilo opcionalmente sustituido con uno o más sustituyentes, heteroarilo opcionalmente sustituido con uno o más sustituyentes, -CH=CH-R1a o -CH2CH2-R1a, en los que R1a es hidrógeno o un resto químico seleccionado de alquilo(C1-C8), anillo(s) carbocíclico(s) de 3 a 8 miembros parcial o totalmente saturado(s), heterociclo de 3 a 6 miembros parcial o totalmente saturado, arilo, heteroarilo, en el que el resto químico está opcionalmente sustituido con uno o más sustituyentes; X es un enlace o -C(R2a) (R2b), en el que R2a y R2b son cada uno independientemente hidrógeno, alquilo (C1-C4) o alquilo (C1-C4) halosustituido;R3a y R3b son cada uno independientemente hidrógeno, alquilo (C1-C4) o alquilo(C1-C4) halosustituido; y R4 es un resto químico seleccionado del grupo que consiste en alquilo (C1-C8), arilo, heteroarilo, aril (alquilo (C1-C4)), anillo(s) carbocíclico (s) de 3 a 8 miembros parcial o totalmente saturado (s), heteroaril(alquilo(C1-C3)), lactona de 5-6 miembros, lactama de 5 a 6 miembros, y un heterociclo de 3 a 6 miembros parcial o totalmente saturado, en el que dicho resto químico está opcionalmente sustituido con uno o más sustituyentes; su sal farmacéuticamente aceptable, un profármaco de dicho compuesto o dicha sal, o un solvato o hidrato de dicho compuesto, dicha sal o dicho profármaco;con la condición de que cuando el compuesto es un compuesto de fórmula (II), R3a y R3b no son ambos hidrógeno cuando X es un enlace.
CO05106974A 2003-04-23 2005-10-21 Ligandos de receptores cannabinoides y sus usos CO5640084A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46490803P 2003-04-23 2003-04-23

Publications (1)

Publication Number Publication Date
CO5640084A2 true CO5640084A2 (es) 2006-05-31

Family

ID=33310977

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05106974A CO5640084A2 (es) 2003-04-23 2005-10-21 Ligandos de receptores cannabinoides y sus usos

Country Status (31)

Country Link
US (1) US20040214856A1 (es)
EP (1) EP1622903B1 (es)
JP (1) JP2006524225A (es)
KR (1) KR20060006048A (es)
CN (1) CN1809566A (es)
AP (1) AP2005003427A0 (es)
AR (1) AR044037A1 (es)
AT (1) ATE409700T1 (es)
AU (1) AU2004232552A1 (es)
BR (1) BRPI0409791A (es)
CA (1) CA2521538A1 (es)
CL (1) CL2004000827A1 (es)
CO (1) CO5640084A2 (es)
DE (1) DE602004016839D1 (es)
EA (1) EA200501504A1 (es)
EC (1) ECSP056117A (es)
ES (1) ES2309517T3 (es)
GT (1) GT200400076A (es)
IS (1) IS8054A (es)
MA (1) MA27766A1 (es)
MX (1) MXPA05011454A (es)
NL (1) NL1026027C2 (es)
NO (1) NO20055516L (es)
OA (1) OA13047A (es)
PA (1) PA8600601A1 (es)
PE (1) PE20050419A1 (es)
TN (1) TNSN05272A1 (es)
TW (1) TW200510419A (es)
UY (1) UY28276A1 (es)
WO (1) WO2004094421A1 (es)
ZA (1) ZA200508568B (es)

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AR044037A1 (es) 2005-08-24
MXPA05011454A (es) 2005-12-12
ECSP056117A (es) 2006-03-01
AU2004232552A1 (en) 2004-11-04
MA27766A1 (fr) 2006-02-01
KR20060006048A (ko) 2006-01-18
AP2005003427A0 (en) 2005-12-31
EA200501504A1 (ru) 2006-04-28
CN1809566A (zh) 2006-07-26
CL2004000827A1 (es) 2005-03-04
JP2006524225A (ja) 2006-10-26
UY28276A1 (es) 2004-11-30
BRPI0409791A (pt) 2006-05-30
ATE409700T1 (de) 2008-10-15
OA13047A (en) 2006-11-10
DE602004016839D1 (de) 2008-11-13
US20040214856A1 (en) 2004-10-28
TNSN05272A1 (fr) 2007-07-10
PE20050419A1 (es) 2005-06-18
WO2004094421A1 (en) 2004-11-04
CA2521538A1 (en) 2004-11-04
IS8054A (is) 2005-09-29
ES2309517T3 (es) 2008-12-16
NL1026027A1 (nl) 2004-10-27
ZA200508568B (en) 2007-04-25
NO20055516L (no) 2005-11-22
EP1622903A1 (en) 2006-02-08
GT200400076A (es) 2004-12-16
NL1026027C2 (nl) 2005-07-05
TW200510419A (en) 2005-03-16
EP1622903B1 (en) 2008-10-01
PA8600601A1 (es) 2005-05-24

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