ATE556058T1 - 1-(2h)-isochinolonderivat - Google Patents

1-(2h)-isochinolonderivat

Info

Publication number
ATE556058T1
ATE556058T1 AT05709816T AT05709816T ATE556058T1 AT E556058 T1 ATE556058 T1 AT E556058T1 AT 05709816 T AT05709816 T AT 05709816T AT 05709816 T AT05709816 T AT 05709816T AT E556058 T1 ATE556058 T1 AT E556058T1
Authority
AT
Austria
Prior art keywords
substituted
hydrogen atom
group
atom
hetero ring
Prior art date
Application number
AT05709816T
Other languages
English (en)
Inventor
Kazuo Hattori
Satoshi Niizuma
Takehiro Okada
Hiroyuki Eda
Kenji Tatsuno
Miyuki Yoshida
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE556058T1 publication Critical patent/ATE556058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT05709816T 2004-02-06 2005-02-07 1-(2h)-isochinolonderivat ATE556058T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004030885 2004-02-06
PCT/JP2005/001764 WO2005075431A1 (ja) 2004-02-06 2005-02-07 １−（２ｈ）−イソキノロン誘導体

Publications (1)

Publication Number Publication Date
ATE556058T1 true ATE556058T1 (de) 2012-05-15

Family

ID=34836016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05709816T ATE556058T1 (de) 2004-02-06 2005-02-07 1-(2h)-isochinolonderivat

Country Status (6)

Country Link
US (1) US8143274B2 (de)
EP (1) EP1724262B1 (de)
JP (1) JP4938311B2 (de)
AT (1) ATE556058T1 (de)
TW (1) TW200536830A (de)
WO (1) WO2005075431A1 (de)

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US7846915B2 (en) 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
TWI389897B (zh) * 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
CA2617213C (en) * 2005-07-29 2014-01-28 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8034829B2 (en) * 2006-11-17 2011-10-11 Rexahn Pharmaceuticals, Inc. 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof
NZ577980A (en) * 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
NZ579355A (en) 2007-02-01 2012-03-30 Resverlogix Corp 2-(Aryl)-4-oxo-quinazoline derivatives
EP2346837B8 (de) 2008-06-26 2015-04-15 Resverlogix Corporation Verfahren zur herstellung von chinazolinonderivaten
US8735391B2 (en) 2008-09-26 2014-05-27 University Of Kansas Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
EP2377871A4 (de) 2008-11-28 2012-07-25 Chugai Pharmaceutical Co Ltd 1-(2h)-isochinolonderivat
EP2660238B1 (de) 2009-01-08 2015-05-06 Resverlogix Corporation Verbindungen zur Vorbeugung und Behandlung von kardiovaskulären Erkrankungen
CA2751892A1 (en) 2009-01-15 2010-07-22 Rutgers, The State University Of New Jersey Benzo [c] phenanthridines as antimicrobial agents
KR101803259B1 (ko) 2009-03-18 2017-11-30 리스버로직스 코퍼레이션 신규한 소염제
BRPI1014956B8 (pt) 2009-04-22 2021-05-25 Resverlogix Corp agentes anti-inflamatórios
WO2010127307A1 (en) * 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CN101602725B (zh) * 2009-07-21 2012-07-11 浙江大学 六氢异喹啉酮类化合物的合成方法
RU2012119488A (ru) * 2009-10-13 2013-11-20 Мсд Осс Б.В. Конденсированные азиновые производные для лечения заболеваний, связанных с ацетилхолиновым рецептором
FR2956816B1 (fr) 2010-03-01 2012-05-18 Univ Joseph Fourier Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
CA2810162A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2803890A1 (en) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
MX346147B (es) 2012-03-07 2017-03-09 Inst Of Cancer Research: Royal Cancer Hospital (The) Compuestos de 3-aril-5-substituido-isoquinolin-1-ona y su uso terapeutico.
US9475783B2 (en) 2012-03-21 2016-10-25 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
US20140275567A1 (en) 2013-03-15 2014-09-18 Johnson Matthey Plc Process for preparing alkyl esters of 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzo[d]imidazol-2-yl)butyric acid
CA2922469A1 (en) * 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2015095446A1 (en) * 2013-12-19 2015-06-25 Ptc Therapeutics, Inc. Methods for modulating the amount of rna transcripts
EP3268007B1 (de) 2015-03-13 2022-11-09 Resverlogix Corp. Zusammensetzungen und therapeutische verfahren zur behandlung von komplementassoziierten erkrankungen
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
PE20181010A1 (es) 2015-11-06 2018-06-26 Neurocrine Biosciences Inc Derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida y compuestos relacionados como antagonistas del receptor muscarinico 4 (m4) para tratar trastornos neurologicos
LT3386511T (lt) 2015-12-10 2021-08-25 Ptc Therapeutics, Inc. Hantingtono ligos gydymo būdai
EP3419967A4 (de) 2016-02-25 2019-10-16 Taxis Pharmaceuticals, Inc. Synthetische verfahren und zwischenprodukte
EP3590931A4 (de) 2017-03-03 2020-11-18 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Amidderivatinhibitor und herstellungsverfahren und anwendung davon
EP3600298A4 (de) 2017-03-30 2020-11-11 Taxis Pharmaceuticals, Inc. Synthetische verfahren und synthetische zwischenprodukte
IL300875A (en) 2017-06-05 2023-04-01 Ptc Therapeutics Inc Compounds for the treatment of Huntington's disease
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
US11395822B2 (en) 2017-06-28 2022-07-26 Ptc Therapeutics, Inc. Methods for treating Huntington's disease
WO2019191092A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
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US4942163A (en) * 1989-03-07 1990-07-17 E. I. Du Pont De Nemours And Company 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
CN1198614C (zh) 1997-05-13 2005-04-27 奥科特默股份有限公司 pADPRT抑制剂在用于制备治疗炎症和炎性疾病的药物中的方法
US20020022636A1 (en) 1997-09-03 2002-02-21 Jia-He Li Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US20040176361A1 (en) * 2001-05-23 2004-09-09 Masakazu Fujio Fused heterocyclic compound and medicinal use thereof
WO2005075432A1 (ja) * 2004-02-06 2005-08-18 Chugai Seiyaku Kabushiki Kaisha １−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用

Also Published As

Publication number Publication date
US8143274B2 (en) 2012-03-27
US20070185160A1 (en) 2007-08-09
WO2005075431A1 (ja) 2005-08-18
TW200536830A (en) 2005-11-16
EP1724262A1 (de) 2006-11-22
EP1724262B1 (de) 2012-05-02
EP1724262A4 (de) 2009-10-21
JP4938311B2 (ja) 2012-05-23
JPWO2005075431A1 (ja) 2007-10-11

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