NO20064297L - Aminoalkoholforbindelse - Google Patents
AminoalkoholforbindelseInfo
- Publication number
- NO20064297L NO20064297L NO20064297A NO20064297A NO20064297L NO 20064297 L NO20064297 L NO 20064297L NO 20064297 A NO20064297 A NO 20064297A NO 20064297 A NO20064297 A NO 20064297A NO 20064297 L NO20064297 L NO 20064297L
- Authority
- NO
- Norway
- Prior art keywords
- group
- pharmacologically acceptable
- lower alkyl
- ethyl
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Farmasøytisk preparat med lav toksistet, bedre fysikalsk-kjemiske egenskaper og farmakokinetika, og bedre aktivitet for senking av lymfocyttantall i perifert blod. Det farmasøytiske preparat inneholder en forbindelse med generell formel (I) hvor R1 representerer en metylgruppe eller en etylgruppe, R2 representerer en metylgruppe eller en etylgruppe, og R3 representerer en fenylgruppe som er substituert med 1 til 3 substituenter valgt fra gruppen bestående av halogenatom, lavere alkylgruppe, sykloalkylgruppe, lavere alkoksygruppe, halogenert-lavere alkylgruppe, lavere alifatisk acylgruppe og cyanogruppe, et farmakologisk akseptabelt salt av denne, eller en farmakologisk akseptabel ester av denne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004048205 | 2004-02-24 | ||
PCT/JP2005/002884 WO2005079788A1 (ja) | 2004-02-24 | 2005-02-23 | アミノアルコール化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20064297L true NO20064297L (no) | 2006-11-23 |
NO337072B1 NO337072B1 (no) | 2016-01-18 |
Family
ID=34879501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20064297A NO337072B1 (no) | 2004-02-24 | 2006-09-22 | (2R)-2-amino-2-metyl-4-{1-metyl-5-[4-(4-metylfenyl)butanoyl]pyrrol-2-yl}butan-1-ol, dens farmakologisk aksepterbare salter og estere og farmasøytiske preparater derav. |
Country Status (15)
Country | Link |
---|---|
US (1) | US7910617B2 (no) |
EP (1) | EP1733724A4 (no) |
JP (1) | JP2005272453A (no) |
KR (2) | KR101182619B1 (no) |
CN (1) | CN1921847B (no) |
AU (1) | AU2005215320B2 (no) |
BR (1) | BRPI0507944A (no) |
CA (1) | CA2557536C (no) |
IL (1) | IL176988A (no) |
NO (1) | NO337072B1 (no) |
NZ (1) | NZ549162A (no) |
RU (1) | RU2332212C2 (no) |
TW (1) | TWI355934B (no) |
WO (1) | WO2005079788A1 (no) |
ZA (1) | ZA200607059B (no) |
Families Citing this family (24)
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IL162874A0 (en) | 2002-01-11 | 2005-11-20 | Sankyo Co | Amino alcohol and phosphonic acid derivatives and pharmaceutical compositions containing the same |
DE602005027074D1 (de) | 2004-07-16 | 2011-05-05 | Kyorin Seiyaku Kk | Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen |
TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
ES2615498T3 (es) * | 2004-10-12 | 2017-06-07 | Kyorin Pharmaceutical Co., Ltd. | Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol |
WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | 2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
ME02095B (en) | 2006-08-08 | 2014-06-30 | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient | |
EP2053038B1 (en) | 2006-08-08 | 2016-10-05 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
TW200906389A (en) * | 2007-05-25 | 2009-02-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition comprising of therapeutic or prophylactic agents for hepatitis |
JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
KR20180023049A (ko) | 2008-07-23 | 2018-03-06 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
CN105816453B (zh) | 2008-08-27 | 2021-03-05 | 艾尼纳制药公司 | 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物 |
CN108558740B (zh) | 2010-01-27 | 2021-10-19 | 艾尼纳制药公司 | S1p1受体调节剂及其盐的制备方法 |
SG10201501575VA (en) | 2010-03-03 | 2015-04-29 | Arena Pharm Inc | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
JP2013533286A (ja) | 2010-07-30 | 2013-08-22 | セントルイス ユニバーシティ | 疼痛を治療する方法 |
WO2012073991A1 (ja) | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | ピロール誘導体及びその製造方法 |
CN103717678B (zh) * | 2011-06-21 | 2015-11-25 | 蓝星有机硅法国公司 | 氢化硅烷化反应的抑制剂及其用于制备稳定的可固化有机硅组合物的用途 |
GB201318886D0 (en) * | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
KR20230151072A (ko) | 2015-01-06 | 2023-10-31 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 상태의 치료 방법 |
CA3002551A1 (en) | 2015-06-22 | 2016-12-29 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders |
MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
CN110545848A (zh) | 2017-02-16 | 2019-12-06 | 艾尼纳制药公司 | 用于治疗具有肠外表现的炎症性肠病的化合物和方法 |
KR20210074291A (ko) | 2018-09-06 | 2021-06-21 | 아레나 파마슈티칼스, 인크. | 자가면역 및 염증성 장애의 치료에 유용한 화합물 |
JP2023501217A (ja) | 2019-10-31 | 2023-01-18 | イドーシア ファーマシューティカルズ リミテッド | Cxcr7アンタゴニストのs1p1受容体調節剤との合剤 |
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-
2005
- 2005-02-23 JP JP2005047784A patent/JP2005272453A/ja active Pending
- 2005-02-23 CN CN2005800059127A patent/CN1921847B/zh not_active Expired - Fee Related
- 2005-02-23 CA CA2557536A patent/CA2557536C/en not_active Expired - Fee Related
- 2005-02-23 NZ NZ549162A patent/NZ549162A/en not_active IP Right Cessation
- 2005-02-23 AU AU2005215320A patent/AU2005215320B2/en not_active Ceased
- 2005-02-23 WO PCT/JP2005/002884 patent/WO2005079788A1/ja active Application Filing
- 2005-02-23 KR KR1020067016943A patent/KR101182619B1/ko not_active IP Right Cessation
- 2005-02-23 EP EP05710577A patent/EP1733724A4/en not_active Withdrawn
- 2005-02-23 TW TW094105413A patent/TWI355934B/zh not_active IP Right Cessation
- 2005-02-23 BR BRPI0507944-6A patent/BRPI0507944A/pt not_active IP Right Cessation
- 2005-02-23 KR KR1020117027976A patent/KR20110136901A/ko not_active Application Discontinuation
- 2005-02-23 RU RU2006130466/15A patent/RU2332212C2/ru not_active IP Right Cessation
- 2005-02-23 US US10/588,818 patent/US7910617B2/en not_active Expired - Fee Related
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2006
- 2006-07-20 IL IL176988A patent/IL176988A/en not_active IP Right Cessation
- 2006-08-23 ZA ZA2006/07059A patent/ZA200607059B/en unknown
- 2006-09-22 NO NO20064297A patent/NO337072B1/no not_active IP Right Cessation
Also Published As
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AU2005215320A1 (en) | 2005-09-01 |
US7910617B2 (en) | 2011-03-22 |
CA2557536A1 (en) | 2005-09-01 |
KR20070022646A (ko) | 2007-02-27 |
AU2005215320B2 (en) | 2008-04-17 |
CN1921847A (zh) | 2007-02-28 |
JP2005272453A (ja) | 2005-10-06 |
IL176988A (en) | 2015-06-30 |
EP1733724A1 (en) | 2006-12-20 |
NO337072B1 (no) | 2016-01-18 |
US20070191468A1 (en) | 2007-08-16 |
RU2006130466A (ru) | 2008-02-27 |
CN1921847B (zh) | 2010-06-16 |
RU2332212C2 (ru) | 2008-08-27 |
KR101182619B1 (ko) | 2012-09-18 |
TWI355934B (en) | 2012-01-11 |
IL176988A0 (en) | 2006-12-10 |
TW200533343A (en) | 2005-10-16 |
NZ549162A (en) | 2009-12-24 |
KR20110136901A (ko) | 2011-12-21 |
CA2557536C (en) | 2010-07-13 |
BRPI0507944A (pt) | 2007-07-24 |
EP1733724A4 (en) | 2010-07-07 |
ZA200607059B (en) | 2008-01-08 |
WO2005079788A1 (ja) | 2005-09-01 |
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