EA200500777A1 - Производные 3-(3,5-диоксо-4,5-дигидро-3h-(1,2,4)триазин-2-ил)бензамида в качестве ингибиторов p2xдля лечения воспалительных заболеваний - Google Patents
Производные 3-(3,5-диоксо-4,5-дигидро-3h-(1,2,4)триазин-2-ил)бензамида в качестве ингибиторов p2xдля лечения воспалительных заболеванийInfo
- Publication number
- EA200500777A1 EA200500777A1 EA200500777A EA200500777A EA200500777A1 EA 200500777 A1 EA200500777 A1 EA 200500777A1 EA 200500777 A EA200500777 A EA 200500777A EA 200500777 A EA200500777 A EA 200500777A EA 200500777 A1 EA200500777 A1 EA 200500777A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- inflammatory diseases
- benzamide
- inhibitors
- triazin
- Prior art date
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Согласно настоящему изобретению предложены бензамидные ингибиторы рецептора P2Xформулы (I), где Rи Rявляются такими, как определено в п.1. Rпредставляет собой связанный с атомом азота (C-C)гетероциклил формулы (II), где Rи Rявляются такими, как определено в п.1. Соединения по изобретению полезны в лечении расстройств, опосредованных IL-1, включая без ограничения воспалительные заболевания, такие как остеоартрит и ревматоидный артрит, аллергии, астму, хроническое обструктивное заболевание легких (ХОЗЛ), рак, реперфузию или ишемию при инсульте или сердечном приступе, аутоиммунные заболевания и другие расстройства.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US43750502P | 2002-12-31 | 2002-12-31 | |
PCT/IB2003/006254 WO2004058270A1 (en) | 2002-12-31 | 2003-12-19 | 3-(3,5-dioxo-4,5-dihydro-3h-(1,2,4)triazin-2-yl)-benzamide derivatives as p2x7-inhibitors for the treatment of inflammatory diseases |
Publications (2)
Publication Number | Publication Date |
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EA200500777A1 true EA200500777A1 (ru) | 2005-12-29 |
EA008591B1 EA008591B1 (ru) | 2007-06-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA200500777A EA008591B1 (ru) | 2002-12-31 | 2003-12-19 | Производные 3-(3,5-диоксо-4,5-дигидро-3h-(1,2,4)триазин-2-ил)бензамида в качестве ингибиторов p2xдля лечения воспалительных заболеваний |
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US (4) | US6974812B2 (ru) |
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Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
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PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
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