EA200801183A1 - Сульфонамидные производные и их применение для модулирования металлопротеаз - Google Patents

Сульфонамидные производные и их применение для модулирования металлопротеаз

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Publication number
EA200801183A1
EA200801183A1 EA200801183A EA200801183A EA200801183A1 EA 200801183 A1 EA200801183 A1 EA 200801183A1 EA 200801183 A EA200801183 A EA 200801183A EA 200801183 A EA200801183 A EA 200801183A EA 200801183 A1 EA200801183 A1 EA 200801183A1
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EA
Eurasian Patent Office
Prior art keywords
proteasis
modulation
metal
application
diseases
Prior art date
Application number
EA200801183A
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English (en)
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EA013907B1 (ru
Inventor
Патрик Жербер
Доминик Свиннен
Аньес Бомбрэн
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Лаборатуар Сероно С.А.
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Application filed by Лаборатуар Сероно С.А. filed Critical Лаборатуар Сероно С.А.
Publication of EA200801183A1 publication Critical patent/EA200801183A1/ru
Publication of EA013907B1 publication Critical patent/EA013907B1/ru

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение относится к сульфонамидным производным формулы (Ia), где группы определены в описании, и к их применению, в частности, для лечения и/или профилактики аутоиммунных заболеваний, воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, рака, респираторных заболеваний и фиброза, включая рассеянный склероз, артрит, эмфизему, хроническое обструктивное заболевание легких, фиброз печени и легких.
EA200801183A 2005-10-26 2006-10-24 Сульфонамидные производные и их применение для модулирования металлопротеаз EA013907B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73040405P 2005-10-26 2005-10-26
EP05110035 2005-10-26
PCT/EP2006/067713 WO2007048788A1 (en) 2005-10-26 2006-10-24 Sulfonamide derivatives and use thereof for the modulation of metalloproteinases

Publications (2)

Publication Number Publication Date
EA200801183A1 true EA200801183A1 (ru) 2008-10-30
EA013907B1 EA013907B1 (ru) 2010-08-30

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EA200801183A EA013907B1 (ru) 2005-10-26 2006-10-24 Сульфонамидные производные и их применение для модулирования металлопротеаз

Country Status (22)

Country Link
US (1) US7879876B2 (ru)
EP (1) EP1951674B1 (ru)
JP (1) JP5203956B2 (ru)
KR (1) KR20080064880A (ru)
CN (1) CN101346353B (ru)
AT (1) ATE534630T1 (ru)
AU (1) AU2006307939B2 (ru)
BR (1) BRPI0617931A2 (ru)
CA (1) CA2623879C (ru)
CY (1) CY1112370T1 (ru)
DK (1) DK1951674T3 (ru)
EA (1) EA013907B1 (ru)
ES (1) ES2372866T3 (ru)
HK (1) HK1123304A1 (ru)
HR (1) HRP20110874T1 (ru)
IL (1) IL190835A (ru)
PL (1) PL1951674T3 (ru)
PT (1) PT1951674E (ru)
RS (1) RS52229B (ru)
SI (1) SI1951674T1 (ru)
WO (1) WO2007048788A1 (ru)
ZA (1) ZA200803327B (ru)

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RU2549899C2 (ru) * 2008-11-11 2015-05-10 Новартис Аг Кристаллические формы гидрохлорида финголимода
RU2637372C2 (ru) * 2011-11-18 2017-12-04 Нитто Денко Корпорейшн Средство для лечения фиброза кишечника
RU2650796C2 (ru) * 2010-08-05 2018-04-17 Нитто Денко Корпорейшн Композиция для восстановления нормальной ткани из фиброзной ткани

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ZA200701232B (en) 2004-07-15 2008-08-27 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
CA2760837C (en) 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
WO2010132437A1 (en) 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
RS54328B1 (en) * 2009-06-19 2016-02-29 Teva Pharmaceutical Industries Ltd. MULTIPLE TREATMENT OF LAKVINIMOD SCLEROSIS
PL2458992T3 (pl) * 2009-07-30 2016-07-29 Teva Pharma Leczenie choroby Leśniowskiego-Crohna z użyciem lakwinimodu
SI2467372T1 (sl) 2009-08-10 2016-09-30 Teva Pharmaceutical Industries Ltd. Zdravljenje motenj, povezanih z BDNF, z uporabo lakvinimoda
CN102781239B (zh) * 2010-03-03 2015-01-21 泰华制药工业有限公司 使用拉喹莫德治疗狼疮关节炎
KR20160129093A (ko) * 2010-03-03 2016-11-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 신장염의 치료
DK2542079T3 (da) * 2010-03-03 2014-08-25 Teva Pharma Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
KR101836547B1 (ko) * 2010-09-17 2018-04-19 고쿠리츠다이가쿠호우진 도쿄다이가쿠 혈소판의 기능을 유지하기 위한 조성물
WO2013055907A1 (en) 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
BR112014018485A8 (pt) 2012-02-03 2017-07-11 Teva Pharma Uso de laquinimod para tratar pacientes com a doença de crohn que falharam com a primeira linha de terapia anti-tnf
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
CN103102304B (zh) * 2013-01-19 2015-03-11 安徽师范大学 N-磺酰基取代四氢异喹啉衍生物的制备方法
WO2023147063A2 (en) * 2022-01-28 2023-08-03 Opna Bio SA Compounds and methods for yap/tead modulation and indications therefor

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JP2003533513A (ja) * 2000-05-15 2003-11-11 ダーウィン・ディスカバリー・リミテッド Ｍｍｐおよびｔｎｆ阻害活性を有するヒドロキサム酸およびカルボン酸誘導体
GB0216383D0 (en) * 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2549899C2 (ru) * 2008-11-11 2015-05-10 Новартис Аг Кристаллические формы гидрохлорида финголимода
RU2650796C2 (ru) * 2010-08-05 2018-04-17 Нитто Денко Корпорейшн Композиция для восстановления нормальной ткани из фиброзной ткани
RU2637372C2 (ru) * 2011-11-18 2017-12-04 Нитто Денко Корпорейшн Средство для лечения фиброза кишечника

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RS52229B (en) 2012-10-31
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AU2006307939B2 (en) 2012-03-29
US7879876B2 (en) 2011-02-01
AU2006307939A1 (en) 2007-05-03
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PL1951674T3 (pl) 2012-04-30
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