DE60205564D1 - N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonisten - Google Patents
N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonistenInfo
- Publication number
- DE60205564D1 DE60205564D1 DE60205564T DE60205564T DE60205564D1 DE 60205564 D1 DE60205564 D1 DE 60205564D1 DE 60205564 T DE60205564 T DE 60205564T DE 60205564 T DE60205564 T DE 60205564T DE 60205564 D1 DE60205564 D1 DE 60205564D1
- Authority
- DE
- Germany
- Prior art keywords
- adamantylalkyl
- receptor antagonists
- benzamide derivatives
- preparation
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33689201P | 2001-11-12 | 2001-11-12 | |
US336892P | 2001-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60205564D1 true DE60205564D1 (de) | 2005-09-22 |
DE60205564T2 DE60205564T2 (de) | 2006-06-01 |
Family
ID=23318138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60205564T Expired - Lifetime DE60205564T2 (de) | 2001-11-12 | 2002-11-07 | N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonisten |
Country Status (10)
Country | Link |
---|---|
US (1) | US6927219B2 (de) |
EP (1) | EP1310493B1 (de) |
JP (1) | JP4001542B2 (de) |
AT (1) | ATE302196T1 (de) |
BR (1) | BR0204588A (de) |
CA (1) | CA2411544C (de) |
DE (1) | DE60205564T2 (de) |
ES (1) | ES2244733T3 (de) |
MX (1) | MXPA02009783A (de) |
WO (1) | WO2003042190A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020182646A1 (en) * | 2001-04-30 | 2002-12-05 | Ke Huazhu | Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
MXPA05011008A (es) * | 2003-04-17 | 2006-03-08 | Affectis Pharmaceuticals Ag | Medios y metodos para diagnosticar y tratar trastornos afectivos. |
CA2525437C (en) * | 2003-05-12 | 2009-04-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
WO2004105797A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
WO2004105798A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A PHARMACEUTICAL COMPOSITION COMPRISING A P2X7-RECEPTOR ANTAGONIST AND A TUMOUR NECROSIS FACTOR α |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
ITMI20040255A1 (it) * | 2004-02-17 | 2004-05-17 | Univ Degli Studi Milano | Sostanze ad attivita' antiangiogenica |
EP2343282B1 (de) | 2004-03-05 | 2015-07-22 | F. Hoffmann-La Roche AG | Diaminpyrimidine als P2X3- und P2X2/3-Antagonisten |
WO2005107804A1 (ja) * | 2004-05-06 | 2005-11-17 | Ono Pharmaceutical Co., Ltd. | 呼吸器疾患治療剤 |
CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
BRPI0512781A (pt) * | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
JPWO2006035876A1 (ja) * | 2004-09-29 | 2008-05-15 | 興和株式会社 | 関節リウマチの予防及び/又は治療薬 |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
WO2006083214A1 (en) * | 2005-02-02 | 2006-08-10 | Astrazeneca Ab | Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor |
JPWO2006104172A1 (ja) * | 2005-03-29 | 2008-09-11 | 興和株式会社 | 関節リウマチの予防及び/又は治療薬 |
WO2007008157A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 2 |
EP1906960A4 (de) * | 2005-07-11 | 2010-03-10 | Astrazeneca Ab | Neue kombination 1 |
JP4850913B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3及びp2x2/3調節因子としてのジアミノピリジン |
CN101253159B (zh) * | 2005-09-01 | 2011-12-07 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物 |
JP4850911B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
EP1941911A4 (de) * | 2005-10-28 | 2011-01-12 | Kowa Co | Verfahren zur prävention und/oder behandlung von rheumatoider arthritis |
EP2033646A4 (de) * | 2006-06-29 | 2009-11-18 | Kowa Co | Vorbeugender und/oder therapeutischer wirkstoff für rheumatoide arthritis |
AU2008228067B2 (en) | 2007-03-22 | 2011-12-08 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
WO2009019503A2 (en) * | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | P2x7 antagonists for use in the treatment of mood disorders |
JP5423679B2 (ja) | 2007-10-31 | 2014-02-19 | 日産化学工業株式会社 | ピリダジノン化合物及びp2x7受容体阻害剤 |
PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
DE602009000550D1 (de) | 2008-03-25 | 2011-02-24 | Affectis Pharmaceuticals Ag | Neuartige P2X7R-Antagonisten und ihre Verwendung |
AU2010237302A1 (en) | 2009-04-14 | 2011-12-01 | Affectis Pharmaceuticals Ag | Novel P2X7R antagonists and their use |
JP5562716B2 (ja) * | 2010-05-12 | 2014-07-30 | 花王株式会社 | 電位依存性カチオンチャネル抑制剤 |
EA201201548A1 (ru) | 2010-05-14 | 2013-05-30 | Эффектис Фармасьютиклз Аг | Новые способы получения p2x7r антагонистов |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
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2002
- 2002-09-30 WO PCT/IB2002/004043 patent/WO2003042190A1/en not_active Application Discontinuation
- 2002-10-03 MX MXPA02009783A patent/MXPA02009783A/es active IP Right Grant
- 2002-11-07 EP EP02257719A patent/EP1310493B1/de not_active Expired - Lifetime
- 2002-11-07 DE DE60205564T patent/DE60205564T2/de not_active Expired - Lifetime
- 2002-11-07 ES ES02257719T patent/ES2244733T3/es not_active Expired - Lifetime
- 2002-11-07 BR BR0204588-5A patent/BR0204588A/pt not_active IP Right Cessation
- 2002-11-07 AT AT02257719T patent/ATE302196T1/de not_active IP Right Cessation
- 2002-11-08 CA CA002411544A patent/CA2411544C/en not_active Expired - Fee Related
- 2002-11-12 JP JP2002327661A patent/JP4001542B2/ja not_active Expired - Fee Related
- 2002-11-12 US US10/292,886 patent/US6927219B2/en not_active Expired - Fee Related
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DE60205564T2 (de) | 2006-06-01 |
CA2411544A1 (en) | 2003-05-12 |
JP4001542B2 (ja) | 2007-10-31 |
US20030144293A1 (en) | 2003-07-31 |
CA2411544C (en) | 2008-10-07 |
ATE302196T1 (de) | 2005-09-15 |
MXPA02009783A (es) | 2003-05-21 |
BR0204588A (pt) | 2003-09-16 |
US6927219B2 (en) | 2005-08-09 |
WO2003042190A1 (en) | 2003-05-22 |
EP1310493A1 (de) | 2003-05-14 |
ES2244733T3 (es) | 2005-12-16 |
EP1310493B1 (de) | 2005-08-17 |
JP2003183263A (ja) | 2003-07-03 |
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