ATE302196T1 - N-adamantylalkyl benzamide derivativen als p2x7- rezeptor antagonisten - Google Patents
N-adamantylalkyl benzamide derivativen als p2x7- rezeptor antagonistenInfo
- Publication number
- ATE302196T1 ATE302196T1 AT02257719T AT02257719T ATE302196T1 AT E302196 T1 ATE302196 T1 AT E302196T1 AT 02257719 T AT02257719 T AT 02257719T AT 02257719 T AT02257719 T AT 02257719T AT E302196 T1 ATE302196 T1 AT E302196T1
- Authority
- AT
- Austria
- Prior art keywords
- adamantylalkyl
- receptor antagonists
- benzamide derivatives
- preparation
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33689201P | 2001-11-12 | 2001-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE302196T1 true ATE302196T1 (de) | 2005-09-15 |
Family
ID=23318138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02257719T ATE302196T1 (de) | 2001-11-12 | 2002-11-07 | N-adamantylalkyl benzamide derivativen als p2x7- rezeptor antagonisten |
Country Status (10)
Country | Link |
---|---|
US (1) | US6927219B2 (de) |
EP (1) | EP1310493B1 (de) |
JP (1) | JP4001542B2 (de) |
AT (1) | ATE302196T1 (de) |
BR (1) | BR0204588A (de) |
CA (1) | CA2411544C (de) |
DE (1) | DE60205564T2 (de) |
ES (1) | ES2244733T3 (de) |
MX (1) | MXPA02009783A (de) |
WO (1) | WO2003042190A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020182646A1 (en) * | 2001-04-30 | 2002-12-05 | Ke Huazhu | Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders |
PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
MXPA05011008A (es) * | 2003-04-17 | 2006-03-08 | Affectis Pharmaceuticals Ag | Medios y metodos para diagnosticar y tratar trastornos afectivos. |
ATE355273T1 (de) * | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
WO2004105797A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
EP1633401A1 (de) * | 2003-05-29 | 2006-03-15 | AstraZeneca AB | Pharmazeutische zusammensetzung mit einem p2x7 rezeptor-antagonisten und einem tumornekrosefaktor alpha |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
ITMI20040255A1 (it) * | 2004-02-17 | 2004-05-17 | Univ Degli Studi Milano | Sostanze ad attivita' antiangiogenica |
CN1930135B (zh) * | 2004-03-05 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶 |
US20080287467A1 (en) * | 2004-05-06 | 2008-11-20 | Gen Tamura | Therapeutic Agent for Respiratory Diseases |
JP2008504363A (ja) * | 2004-06-29 | 2008-02-14 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | P2x7受容体のベンズアミド阻害剤を利用する併用療法 |
EP1776352A1 (de) * | 2004-06-29 | 2007-04-25 | Pfizer Products Inc. | Verfahren zur herstellung von 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h[1,2,4]triazin-2-yl]benzamidderivativen durch entschützen der hydroxylgeschützten vorstufen |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
CN101031305A (zh) * | 2004-09-29 | 2007-09-05 | 兴和株式会社 | 类风湿性关节炎的预防和/或治疗药物 |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
WO2006083214A1 (en) * | 2005-02-02 | 2006-08-10 | Astrazeneca Ab | Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor |
WO2006104172A1 (ja) * | 2005-03-29 | 2006-10-05 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療薬 |
WO2007008157A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 2 |
US20080207577A1 (en) * | 2005-07-11 | 2008-08-28 | Astrazeneca Ab | Combination I |
JP4850913B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3及びp2x2/3調節因子としてのジアミノピリジン |
JP4850911B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
BRPI0615613A2 (pt) * | 2005-09-01 | 2009-05-19 | Hoffmann La Roche | diaminopirimidinas como moduladores de p2x3 e p3x2/3 |
EP1941911A4 (de) * | 2005-10-28 | 2011-01-12 | Kowa Co | Verfahren zur prävention und/oder behandlung von rheumatoider arthritis |
US20090203701A1 (en) * | 2006-06-29 | 2009-08-13 | Kowa Co., Ltd | Prophylactic and/or therapeutic agent for rheumatoid arthritis |
ES2388454T3 (es) | 2007-03-22 | 2012-10-15 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias |
WO2009019503A2 (en) * | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | P2x7 antagonists for use in the treatment of mood disorders |
RU2010121763A (ru) | 2007-10-31 | 2011-12-10 | Ниссан Кемикал Индастриз, Лтд. (Jp) | Производные пиридазинона и ингибиторы р2х7 рецептора |
PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
DE602009000550D1 (de) | 2008-03-25 | 2011-02-24 | Affectis Pharmaceuticals Ag | Neuartige P2X7R-Antagonisten und ihre Verwendung |
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2002
- 2002-09-30 WO PCT/IB2002/004043 patent/WO2003042190A1/en not_active Application Discontinuation
- 2002-10-03 MX MXPA02009783A patent/MXPA02009783A/es active IP Right Grant
- 2002-11-07 AT AT02257719T patent/ATE302196T1/de not_active IP Right Cessation
- 2002-11-07 ES ES02257719T patent/ES2244733T3/es not_active Expired - Lifetime
- 2002-11-07 EP EP02257719A patent/EP1310493B1/de not_active Expired - Lifetime
- 2002-11-07 BR BR0204588-5A patent/BR0204588A/pt not_active IP Right Cessation
- 2002-11-07 DE DE60205564T patent/DE60205564T2/de not_active Expired - Lifetime
- 2002-11-08 CA CA002411544A patent/CA2411544C/en not_active Expired - Fee Related
- 2002-11-12 US US10/292,886 patent/US6927219B2/en not_active Expired - Fee Related
- 2002-11-12 JP JP2002327661A patent/JP4001542B2/ja not_active Expired - Fee Related
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JP2003183263A (ja) | 2003-07-03 |
DE60205564T2 (de) | 2006-06-01 |
MXPA02009783A (es) | 2003-05-21 |
WO2003042190A1 (en) | 2003-05-22 |
US20030144293A1 (en) | 2003-07-31 |
DE60205564D1 (de) | 2005-09-22 |
ES2244733T3 (es) | 2005-12-16 |
JP4001542B2 (ja) | 2007-10-31 |
CA2411544A1 (en) | 2003-05-12 |
EP1310493B1 (de) | 2005-08-17 |
CA2411544C (en) | 2008-10-07 |
EP1310493A1 (de) | 2003-05-14 |
US6927219B2 (en) | 2005-08-09 |
BR0204588A (pt) | 2003-09-16 |
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