HRP20220223T1 - Biciklički inhibitori histon deacetilaze - Google Patents
Biciklički inhibitori histon deacetilaze Download PDFInfo
- Publication number
- HRP20220223T1 HRP20220223T1 HRP20220223TT HRP20220223T HRP20220223T1 HR P20220223 T1 HRP20220223 T1 HR P20220223T1 HR P20220223T T HRP20220223T T HR P20220223TT HR P20220223 T HRP20220223 T HR P20220223T HR P20220223 T1 HRP20220223 T1 HR P20220223T1
- Authority
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- Croatia
- Prior art keywords
- disorder
- disease
- pharmaceutically acceptable
- compound
- acceptable salt
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title claims 2
- 108090000353 Histone deacetylase Proteins 0.000 title claims 2
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 6
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 5
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000020358 Learning disease Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 201000003723 learning disability Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010003591 Ataxia Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 230000007000 age related cognitive decline Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000014951 hematologic disease Diseases 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 206010039281 Rubinstein-Taybi syndrome Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000014061 fear response Effects 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000019899 phobic disease Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 231100000736 substance abuse Toxicity 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (8)
1. Spoj formule:
[image]
ili njegova farmaceutski prihvatljiva sol.
2. Spoj prema zahtjevu 1, naznačen time što je spoj formule:
[image]
ili njegova farmaceutski prihvatljiva sol.
3. Spoj prema zahtjevu 1, naznačen time što je spoj formule:
[image]
ili njegova farmaceutski prihvatljiva sol.
4. Farmaceutski pripravak, naznačen time, da sadrži spoj prema bilo kojem od zahtjeva 1 do 3, ili njegovu farmaceutski prihvatljivu sol; i farmaceutski prihvatljiv nosač.
5. Spoj prema bilo kojem od zahtjeva 1 do 3, ili njegova farmaceutski prihvatljiva sol, ili farmaceutski pripravak prema zahtjevu 4, za uporabu u liječenju stanja povezanih s aktivnošću HDAC.
6. Spoj prema bilo kojem od zahtjeva 1 do 3, ili njegova farmaceutski prihvatljiva sol, ili farmaceutski pripravak prema zahtjevu 4, za uporabu u liječenju stanja odabranog od neurološkog poremećaja, poremećaja pamćenja ili kognitivnih funkcija ili oštećenja, poremećaja učenja, gljivične bolesti ili infekcije, upalne bolesti, hematološke bolesti, psihijatrijskog poremećaja i neoplastične bolesti.
7. Spoj ili pripravak za uporabu u zahtjevu 6, naznačen time, da je stanje:
a. poremećaj ili oštećenje kognitivnih funkcija povezano s Alzheimerovom bolešću, Huntingtonovom bolešću, gubitkom pamćenja uzrokovanog napadajima, shizofrenijom, Rubinstein Taybijevim sindromom, Rettovim sindromom, depresijom, Fragile X, demencijom Lewyjevog tijela, vaskularnom demencijom, degeneracijom fronto-temporalnog režnja (fronto-temporalnom demencijom, FTD), FTD-GRN, ADHD, disleksijom, bipolarnim poremećajem te socijalnim, kognitivnim i poremećajima učenja povezanih s autizmom, traumatskim ozljedama glave, poremećajem pažnje, anksioznim poremećajem, uvjetovanim odgovorom na strah, poremećajem panike, opsesivno kompulzivnim poremećajem, posttraumatskim stresnim poremećajem (PTSP), fobijom, socijalnim anksioznim poremećajem, oporavkom od ovisnosti o supstancijama, oštećenjem pamćenja povezanom s dobi (AAMI), kognitivnim padom povezanim s dobi (ARCD), ataksijom, Parkinsonovom bolesti ili demencijom Parkinsonove bolesti; ili
b. hematološka bolest odabrana između akutne mijeloične leukemije, akutne promijelocitne leukemije, akutne limfoblastne leukemije, kronične mijeloične leukemije, mijelodisplastičnih sindroma i anemije srpastih stanica; ili
c. neoplastična bolest; ili
d. poremećaj učenja odabran između straha i posttraumatskog stresnog poremećaja.
8. Spoj ili pripravak za uporabu u zahtjevu 7, naznačen time, da je stanje Alzheimerova bolest, Huntingtonova bolest, frontotemporalna demencija, Freidreichova ataksija, posttraumatski stresni poremećaj (PTSP), Parkinsonova bolest ili oporavak od ovisnosti o opojnim sredstvima.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762445022P | 2017-01-11 | 2017-01-11 | |
US201762555298P | 2017-09-07 | 2017-09-07 | |
PCT/US2018/013260 WO2018132531A1 (en) | 2017-01-11 | 2018-01-11 | Bicyclic inhibitors of histone deacetylase |
EP18702839.4A EP3570834B1 (en) | 2017-01-11 | 2018-01-11 | Bicyclic inhibitors of histone deacetylase |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20220223T1 true HRP20220223T1 (hr) | 2022-04-29 |
Family
ID=61074595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220223TT HRP20220223T1 (hr) | 2017-01-11 | 2018-01-11 | Biciklički inhibitori histon deacetilaze |
Country Status (26)
Country | Link |
---|---|
US (7) | US9951069B1 (hr) |
EP (2) | EP3568135B1 (hr) |
JP (1) | JP6756925B2 (hr) |
KR (1) | KR102526032B1 (hr) |
CN (1) | CN110290789B (hr) |
AU (1) | AU2018207402B2 (hr) |
BR (1) | BR112019014235A2 (hr) |
CA (1) | CA3049443A1 (hr) |
CY (1) | CY1125287T1 (hr) |
DK (1) | DK3570834T3 (hr) |
ES (2) | ES2875562T3 (hr) |
HR (1) | HRP20220223T1 (hr) |
HU (1) | HUE057849T2 (hr) |
IL (1) | IL267953B2 (hr) |
LT (1) | LT3570834T (hr) |
MA (1) | MA47305A (hr) |
MD (1) | MD3570834T2 (hr) |
MX (1) | MX2019008302A (hr) |
PL (1) | PL3570834T3 (hr) |
PT (1) | PT3570834T (hr) |
RS (1) | RS62959B1 (hr) |
SG (1) | SG11201906164RA (hr) |
SI (1) | SI3570834T1 (hr) |
TW (1) | TWI770104B (hr) |
WO (2) | WO2018132531A1 (hr) |
ZA (1) | ZA201904459B (hr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3319959T3 (pl) * | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
EP3568135B1 (en) | 2017-01-11 | 2021-04-07 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
JP7152471B2 (ja) * | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
US20220227700A1 (en) * | 2019-06-13 | 2022-07-21 | Dana-Farber Cancer Institute, Inc. | Hdac3 catalytic inhibitor development and uses thereof |
US20220267323A1 (en) * | 2019-07-23 | 2022-08-25 | Alkermes, Inc. | Synthesis of bicyclic inhibitors of histone deacetylase |
CN110734924B (zh) * | 2019-10-25 | 2020-10-23 | 山东大学第二医院 | 一种抑郁症检测、治疗和预后靶点及应用 |
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