FR2763944B1 - Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases - Google Patents
Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteasesInfo
- Publication number
- FR2763944B1 FR2763944B1 FR9706814A FR9706814A FR2763944B1 FR 2763944 B1 FR2763944 B1 FR 2763944B1 FR 9706814 A FR9706814 A FR 9706814A FR 9706814 A FR9706814 A FR 9706814A FR 2763944 B1 FR2763944 B1 FR 2763944B1
- Authority
- FR
- France
- Prior art keywords
- drugs
- processes
- preparation
- protease inhibitors
- coumarin derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9706814A FR2763944B1 (fr) | 1997-06-03 | 1997-06-03 | Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases |
PCT/FR1998/001087 WO1998055472A1 (fr) | 1997-06-03 | 1998-05-29 | Derives de coumarines, leurs procedes de preparation et leur application comme medicaments |
EP98928394A EP0988298A1 (fr) | 1997-06-03 | 1998-05-29 | Derives de coumarines, leurs procedes de preparation et leur application comme medicaments |
JP50170799A JP2002503241A (ja) | 1997-06-03 | 1998-05-29 | クマリン誘導体、それらの製造方法及び医薬品としてのそれらの用途 |
US09/445,177 US6355658B1 (en) | 1997-06-03 | 1998-05-29 | Coumarin derivatives, methods of preparation and application as medicines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9706814A FR2763944B1 (fr) | 1997-06-03 | 1997-06-03 | Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2763944A1 FR2763944A1 (fr) | 1998-12-04 |
FR2763944B1 true FR2763944B1 (fr) | 2000-12-15 |
Family
ID=9507531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9706814A Expired - Fee Related FR2763944B1 (fr) | 1997-06-03 | 1997-06-03 | Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases |
Country Status (5)
Country | Link |
---|---|
US (1) | US6355658B1 (fr) |
EP (1) | EP0988298A1 (fr) |
JP (1) | JP2002503241A (fr) |
FR (1) | FR2763944B1 (fr) |
WO (1) | WO1998055472A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1506359A (zh) * | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
ATE375212T1 (de) * | 2003-06-27 | 2007-10-15 | Recticel | Verfahren zur herstellung eines formteils welches eine gesprühte polyurethschicht umfasst |
AR059339A1 (es) * | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
GB0607389D0 (en) * | 2006-04-12 | 2006-05-24 | Novartis Ag | Organic compounds |
KR101511396B1 (ko) * | 2007-07-20 | 2015-04-13 | 추가이 세이야쿠 가부시키가이샤 | p27 단백질 유도제 |
EP2545916A1 (fr) | 2011-07-15 | 2013-01-16 | Universite Pierre Et Marie Curie - Paris 6 | Utilisation de dérivés de coumarine pour la préparation de médicaments prévus pour traiter des maladies cutanées |
EP2548973A1 (fr) | 2011-07-20 | 2013-01-23 | Centre National de la Recherche Scientifique | Nouvelle composition de souche d'actinomycète et son utilisation |
JP6936796B2 (ja) | 2015-07-06 | 2021-09-22 | ロダン・セラピューティクス,インコーポレーテッド | ヒストンデアセチラーゼのヘテロハロ阻害剤 |
WO2017007755A1 (fr) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | N-aminophényl-amides hétérocycliques en tant qu'inhibiteurs de l'histone désacétylase |
US9951069B1 (en) | 2017-01-11 | 2018-04-24 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
WO2023213728A1 (fr) | 2022-05-03 | 2023-11-09 | Université de Liège | Esters d'aryle substitués d'acide coumarine-3-carboxylique et leur utilisation en tant qu'inhibiteurs de protéases de cellules hôte |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2683720A (en) * | 1949-12-15 | 1954-07-13 | Endo Products Inc | Process for the preparation of 6-nitro-coumarin-3-carboxylic acid |
GB772215A (en) * | 1954-06-23 | 1957-04-10 | Cilag Ltd | Process for the production of new di-acylated tartaric acids |
JPS5692261A (en) * | 1979-12-26 | 1981-07-25 | Nippon Chemiphar Co Ltd | Novel cyclohexanecarboxylic derivative and its preparation |
JPS59204173A (ja) * | 1983-04-28 | 1984-11-19 | Kowa Co | ベンゾイルピペラジンエステル類 |
US4665070A (en) * | 1985-06-25 | 1987-05-12 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use |
JPS6445400A (en) * | 1988-04-21 | 1989-02-17 | Green Cross Corp | Human urinary trypsin inhibitor derivative and production thereof |
NL8900943A (nl) * | 1989-04-14 | 1990-11-01 | Euro Biopharm Technology B V | Protease inhibitor. |
JP2999841B2 (ja) * | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | 発光スクリーン用樹脂組成物 |
US5480907A (en) * | 1991-05-16 | 1996-01-02 | Takeda Chemical Industries, Ltd. | Aromatic amide compounds and their production and use |
JPH05169853A (ja) * | 1991-12-26 | 1993-07-09 | Mitsui Toatsu Chem Inc | 感熱転写記録用色素、感熱転写記録用インキ組成物、及び転写シート |
CA2087413A1 (fr) * | 1992-01-17 | 1993-07-18 | Joseph R. Lakowicz | Dosage immunologique fluorimetrique |
JPH06145164A (ja) * | 1992-11-04 | 1994-05-24 | Mitsui Toatsu Chem Inc | 紫外線吸収剤およびそれに適したベンゾピラン誘導体ならびに該紫外線吸収剤を含有してなる熱可塑性樹脂組成物および成形体 |
ATE211765T1 (de) * | 1994-10-28 | 2002-01-15 | Vitaleech Bioscience N V | Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen |
-
1997
- 1997-06-03 FR FR9706814A patent/FR2763944B1/fr not_active Expired - Fee Related
-
1998
- 1998-05-29 US US09/445,177 patent/US6355658B1/en not_active Expired - Fee Related
- 1998-05-29 JP JP50170799A patent/JP2002503241A/ja not_active Ceased
- 1998-05-29 EP EP98928394A patent/EP0988298A1/fr not_active Withdrawn
- 1998-05-29 WO PCT/FR1998/001087 patent/WO1998055472A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US6355658B1 (en) | 2002-03-12 |
FR2763944A1 (fr) | 1998-12-04 |
JP2002503241A (ja) | 2002-01-29 |
WO1998055472A1 (fr) | 1998-12-10 |
EP0988298A1 (fr) | 2000-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20120309 |