NO985262L - Nye fosfonsyresubstituerte benzazepinon-N-edikksyrederivater, fremgangsmÕte for deres fremstilling, og legemidler inneholdende slike - Google Patents

Nye fosfonsyresubstituerte benzazepinon-N-edikksyrederivater, fremgangsmÕte for deres fremstilling, og legemidler inneholdende slike

Info

Publication number
NO985262L
NO985262L NO985262A NO985262A NO985262L NO 985262 L NO985262 L NO 985262L NO 985262 A NO985262 A NO 985262A NO 985262 A NO985262 A NO 985262A NO 985262 L NO985262 L NO 985262L
Authority
NO
Norway
Prior art keywords
processes
preparation
drugs containing
acetic acid
acid derivatives
Prior art date
Application number
NO985262A
Other languages
English (en)
Other versions
NO985262D0 (no
NO317640B1 (no
Inventor
Harald Waldeck
J Rg Meil
Dirk Thormohlen
Michael Wurl
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO985262D0 publication Critical patent/NO985262D0/no
Publication of NO985262L publication Critical patent/NO985262L/no
Publication of NO317640B1 publication Critical patent/NO317640B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19985262A 1997-11-12 1998-11-11 Nye fosfonsyresubstituerte benzazepinon-N-edikksyrederivater, fremgangsmate for deres fremstilling, og legemidler inneholdende slike NO317640B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19750002A DE19750002A1 (de) 1997-11-12 1997-11-12 Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
NO985262D0 NO985262D0 (no) 1998-11-11
NO985262L true NO985262L (no) 1999-05-14
NO317640B1 NO317640B1 (no) 2004-11-29

Family

ID=7848410

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19985262A NO317640B1 (no) 1997-11-12 1998-11-11 Nye fosfonsyresubstituerte benzazepinon-N-edikksyrederivater, fremgangsmate for deres fremstilling, og legemidler inneholdende slike

Country Status (27)

Country Link
US (1) US5952327A (no)
EP (1) EP0916679B1 (no)
JP (1) JP4162780B2 (no)
KR (1) KR19990045100A (no)
CN (1) CN1187361C (no)
AR (1) AR009911A1 (no)
AT (1) ATE228144T1 (no)
AU (1) AU746907B2 (no)
BR (1) BR9804582A (no)
CA (1) CA2253997C (no)
CZ (1) CZ296123B6 (no)
DE (2) DE19750002A1 (no)
DK (1) DK0916679T3 (no)
DZ (1) DZ2652A1 (no)
ES (1) ES2186961T3 (no)
HU (1) HU221177B1 (no)
ID (1) ID21393A (no)
IL (1) IL126984A (no)
NO (1) NO317640B1 (no)
NZ (1) NZ332744A (no)
PL (1) PL191436B1 (no)
PT (1) PT916679E (no)
RU (1) RU2211219C2 (no)
SK (1) SK283233B6 (no)
TR (1) TR199802289A2 (no)
UA (1) UA60304C2 (no)
ZA (1) ZA9810316B (no)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
SK14102003A3 (sk) * 2001-05-18 2004-08-03 Solvay Pharmaceuticals Gmbh Použitie zlúčenín s kombinovanou inhibičnou aktivitou k NEP/MP pri príprave liečiv
PT1438316E (pt) * 2001-10-19 2006-10-31 Ortho Mcneil Pharm Inc Compostos de acido fosfonico como inibidores de serina proteases
BR0306701A (pt) * 2002-01-16 2004-12-28 Solvay Pharm Bv Composto, sal do composto, sal de cálcio, método de preparação de um sal, composição farmacêutica, método de preparação de uma composição, e, uso de um sal
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
US7427611B2 (en) * 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
US7232813B2 (en) * 2004-01-12 2007-06-19 Solvay Pharmaceuticals B.V. Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders
PL1706121T3 (pl) * 2004-01-12 2009-02-27 Turski Lechoslaw Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (HSEP) do zapobiegania i leczenia zaburzeń neurodegeneracyjnych
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
EP1776095A1 (en) * 2004-06-23 2007-04-25 Solvay Pharmaceuticals GmbH Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and at1-receptor antagonists
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
WO2006064016A1 (en) 2004-12-15 2006-06-22 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and hmg coa reductase inhibitors
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
ATE464904T1 (de) * 2005-02-18 2010-05-15 Solvay Pharm Gmbh Pharmazeutische zusammensetzungen mit nep- inhibitoren, inhibitoren des endogenes endothelin produzierenden systems und diuretika
PL1968990T3 (pl) * 2005-12-27 2015-06-30 Otsuka Pharma Co Ltd Rozpuszczalny w wodzie związek benzoazepinowy i jego kompozycja farmaceutyczna
WO2007102171A2 (en) * 2006-03-07 2007-09-13 Panacea Biotec Ltd Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition
US8198341B2 (en) 2008-12-18 2012-06-12 Icl-Ip America Inc. Method of making hydroxymethylphosphonate, polyurethane foam-forming compositions, polyurethane foam and articles made therefrom
US9441001B2 (en) 2012-10-17 2016-09-13 Icl-Ip America Inc. Method of making hydroxymethylphosphonate, polyurethane foam-forming compositions, polyurethane foam and articles made therefrom
US9528269B2 (en) 2014-06-09 2016-12-27 Johns Manville Roofing systems and roofing boards with non-halogenated fire retardant
US9815256B2 (en) 2014-06-09 2017-11-14 Johns Manville Foam boards including non-halogenated fire retardants
US9523195B2 (en) 2014-06-09 2016-12-20 Johns Manville Wall insulation boards with non-halogenated fire retardant and insulated wall systems
US9815966B2 (en) 2014-07-18 2017-11-14 Johns Manville Spray foams containing non-halogenated fire retardants
CN107383084A (zh) * 2017-06-14 2017-11-24 浙江嘉华化工有限公司 一种0‑乙基磷酸钠的制备方法
PL424453A1 (pl) 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)
PL424452A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
CN115466754A (zh) * 2022-08-24 2022-12-13 中国人民解放军军事科学院防化研究院 一类P-手性α-羟(酯)基磷酸酯类化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW198715B (no) * 1991-04-19 1993-01-21 Dtsuka Seiyaku Kk
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors

Also Published As

Publication number Publication date
PL191436B1 (pl) 2006-05-31
EP0916679B1 (de) 2002-11-20
EP0916679A1 (de) 1999-05-19
IL126984A0 (en) 1999-09-22
HU221177B1 (en) 2002-08-28
JP4162780B2 (ja) 2008-10-08
BR9804582A (pt) 2000-05-09
NO985262D0 (no) 1998-11-11
DE59806345D1 (de) 2003-01-02
SK151698A3 (en) 1999-05-07
HUP9802517A3 (en) 2000-06-28
US5952327A (en) 1999-09-14
CN1187361C (zh) 2005-02-02
DE19750002A1 (de) 1999-05-20
AU746907B2 (en) 2002-05-02
AR009911A1 (es) 2000-05-03
DK0916679T3 (da) 2002-12-16
AU9234498A (en) 2000-06-08
DZ2652A1 (fr) 2003-03-15
RU2211219C2 (ru) 2003-08-27
HK1019338A1 (en) 2000-02-03
ZA9810316B (en) 1999-05-18
HUP9802517A2 (hu) 1999-09-28
CA2253997A1 (en) 1999-05-12
CZ356298A3 (cs) 1999-06-16
SK283233B6 (sk) 2003-04-01
TR199802289A3 (tr) 1999-06-21
IL126984A (en) 2001-07-24
CN1217334A (zh) 1999-05-26
ID21393A (id) 1999-06-03
PT916679E (pt) 2003-03-31
PL329635A1 (en) 1999-05-24
UA60304C2 (uk) 2003-10-15
CA2253997C (en) 2009-05-12
NO317640B1 (no) 2004-11-29
TR199802289A2 (xx) 1999-06-21
CZ296123B6 (cs) 2006-01-11
ATE228144T1 (de) 2002-12-15
JPH11292886A (ja) 1999-10-26
NZ332744A (en) 2000-06-23
ES2186961T3 (es) 2003-05-16
HU9802517D0 (en) 1998-12-28
KR19990045100A (ko) 1999-06-25

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