PL424452A1 - Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu - Google Patents
Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczuInfo
- Publication number
- PL424452A1 PL424452A1 PL424452A PL42445218A PL424452A1 PL 424452 A1 PL424452 A1 PL 424452A1 PL 424452 A PL424452 A PL 424452A PL 42445218 A PL42445218 A PL 42445218A PL 424452 A1 PL424452 A1 PL 424452A1
- Authority
- PL
- Poland
- Prior art keywords
- endopeptidase
- hsep
- nep
- prevention
- treatment
- Prior art date
Links
- 102000005593 Endopeptidases Human genes 0.000 title abstract 3
- 108010059378 Endopeptidases Proteins 0.000 title abstract 3
- 208000030533 eye disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 102000003729 Neprilysin Human genes 0.000 abstract 2
- 108090000028 Neprilysin Proteins 0.000 abstract 2
- ZCXLTWVZYXBHJS-UHFFFAOYSA-N 1,2-benzoxazepine Chemical class O1N=CC=CC2=CC=CC=C12 ZCXLTWVZYXBHJS-UHFFFAOYSA-N 0.000 abstract 1
- DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical class N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 abstract 1
- QJJDBWAEIBNZPQ-UHFFFAOYSA-N 2-(3h-1,2-benzothiazepin-2-yl)acetic acid Chemical class S1N(CC(=O)O)CC=CC2=CC=CC=C21 QJJDBWAEIBNZPQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 phosphono-substituted benzazepinone Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Zgłoszenie dotyczy nowego zastosowania pochodnych benzazepiny, benzoksazepiny, kwasu benzotiazepino-N-octowego oraz fosfono-podstawionego benzazepinonu o aktywności hamującej obojętną endopeptydazę (NEP) i/lub ludzką rozpuszczalną endopeptydazę (hSEP). Związki te stosuje się do wytwarzania kompozycji farmaceutycznych do profilaktyki i leczenia chorób oczu.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL424452A PL424452A1 (pl) | 2018-01-31 | 2018-01-31 | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
HRP20240728TT HRP20240728T1 (hr) | 2018-01-31 | 2019-01-31 | Inhibitori neutralne endopeptidaze (nep) i humane topljive endopeptidaze (hsep) za profilaksu i liječenje bolesti oka |
MX2020007989A MX2020007989A (es) | 2018-01-31 | 2019-01-31 | Inhibidores de endopeptidasa neutra (nep) y endopeptidasa soluble humana (hsep) para profilaxis y tratamiento de enfermedades oftalmologicas. |
TW108103768A TWI762760B (zh) | 2018-01-31 | 2019-01-31 | 用於預防或治療眼部疾病的中性肽鏈內切酶(NEP)及人類可溶性肽鏈內切酶(hSEP)之抑制劑 |
EP19747023.0A EP3746106B1 (en) | 2018-01-31 | 2019-01-31 | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of eye diseases |
RS20240670A RS65651B1 (sr) | 2018-01-31 | 2019-01-31 | Inhibitori neutralne endopeptidaze (nep) i humane rastvorive endopeptidaze (hsep) za profilaksu i lečenje očnih bolesti |
PL19747023.0T PL3746106T3 (pl) | 2018-01-31 | 2019-01-31 | Inhibitory obojętnej endopeptydazy (nep) i ludzkiej rozpuszczalnej endopeptydazy (hsep) do profilaktyki i leczenia chorób oczu |
US16/963,234 US20210046097A1 (en) | 2018-01-31 | 2019-01-31 | NEUTRAL ENDOPEPTIDASE (NEP) AND HUMAN SOLUBLE ENDOPEPTIDASE (hSEP) INHIBITORS FOR PROPHYLAXIS AND TREATMENT OF EYE DISEASES |
PCT/PL2019/000012 WO2019151882A1 (en) | 2018-01-31 | 2019-01-31 | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of eye diseases |
CA3088966A CA3088966A1 (en) | 2018-01-31 | 2019-01-31 | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of eye diseases |
RU2020125048A RU2758771C1 (ru) | 2018-01-31 | 2019-01-31 | ИНГИБИТОРЫ НЕЙТРАЛЬНОЙ ЭНДОПЕПТИДАЗЫ (НЭП) И РАСТВОРИМОЙ ЭНДОПЕПТИДАЗЫ ЧЕЛОВЕКА (РЭПч) ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ГЛАЗНЫХ БОЛЕЗНЕЙ |
CN201980011177.2A CN111757750A (zh) | 2018-01-31 | 2019-01-31 | 用于预防和治疗眼病的中性内肽酶(nep)及人类可溶性内肽酶(hsep)的抑制剂 |
KR1020207025030A KR20200116145A (ko) | 2018-01-31 | 2019-01-31 | 안 질환의 예방 및 치료를 위한 중성 엔도펩티다제 (NEP) 및 사람 용해성 엔도펩티다제 (hSEP) 억제제 |
ZA2019/05959A ZA201905959B (en) | 2018-01-31 | 2019-09-10 | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of eye diseases |
IL275984A IL275984A (en) | 2018-01-31 | 2020-07-12 | Human neutral endopeptidase and soluble endopeptidase inhibitors for the prevention and treatment of eye diseases |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL424452A PL424452A1 (pl) | 2018-01-31 | 2018-01-31 | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
Publications (1)
Publication Number | Publication Date |
---|---|
PL424452A1 true PL424452A1 (pl) | 2019-08-12 |
Family
ID=67478423
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL424452A PL424452A1 (pl) | 2018-01-31 | 2018-01-31 | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
PL19747023.0T PL3746106T3 (pl) | 2018-01-31 | 2019-01-31 | Inhibitory obojętnej endopeptydazy (nep) i ludzkiej rozpuszczalnej endopeptydazy (hsep) do profilaktyki i leczenia chorób oczu |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL19747023.0T PL3746106T3 (pl) | 2018-01-31 | 2019-01-31 | Inhibitory obojętnej endopeptydazy (nep) i ludzkiej rozpuszczalnej endopeptydazy (hsep) do profilaktyki i leczenia chorób oczu |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210046097A1 (pl) |
EP (1) | EP3746106B1 (pl) |
KR (1) | KR20200116145A (pl) |
CN (1) | CN111757750A (pl) |
CA (1) | CA3088966A1 (pl) |
HR (1) | HRP20240728T1 (pl) |
IL (1) | IL275984A (pl) |
MX (1) | MX2020007989A (pl) |
PL (2) | PL424452A1 (pl) |
RS (1) | RS65651B1 (pl) |
RU (1) | RU2758771C1 (pl) |
TW (1) | TWI762760B (pl) |
WO (1) | WO2019151882A1 (pl) |
ZA (1) | ZA201905959B (pl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102647920B1 (ko) | 2021-10-13 | 2024-03-13 | 영남대학교 산학협력단 | 거짓비늘 녹내장 바이오 마커 |
CN117100845A (zh) * | 2022-10-24 | 2023-11-24 | 景泽生物医药(合肥)股份有限公司 | 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL191436B1 (pl) * | 1997-11-12 | 2006-05-31 | Solvay Pharm Gmbh | Podstawione ugrupowaniem kwasu fosfonowego pochodne benzazepinonu zawierające przy atomie N-ugrupowanie kwasu octowego, sposób ich wytwarzania i środki farmaceutyczne zawierające te związki |
EP1706121A1 (en) * | 2004-01-12 | 2006-10-04 | Solvay Pharmaceuticals B.V. | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders |
WO2007056497A1 (en) * | 2005-11-07 | 2007-05-18 | Irm Llc | Compounds and compositions as ppar modulators |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
ATE400277T1 (de) * | 1998-03-05 | 2008-07-15 | Senju Pharma Co | Pharmazeutische zusammenstellung zur vorbeugung und behandlung von mit zellkrankheiten des augenhintergrundes zusammenhängenden krankheiten |
AR039352A1 (es) * | 2001-05-18 | 2005-02-16 | Solvay Pharm Gmbh | Uso de un compuesto que tiene actividad inhibitoria combinada y concurrente con endopeptidasa neutra y metaloproteasa igs5. |
RU2303041C2 (ru) | 2002-01-16 | 2007-07-20 | Солвей Фармасьютикалс Б.В. | Твердые соли бензазепиновых соединений и их применение при получении фармацевтических соединений |
AR038681A1 (es) | 2002-02-14 | 2005-01-26 | Solvay Pharm Bv | Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua |
WO2004062692A1 (en) | 2003-01-13 | 2004-07-29 | Solvay Pharmaceuticals B.V. | Formulation of poorly water-soluble active substances |
CL2004000545A1 (es) | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
WO2005039639A2 (en) * | 2003-10-10 | 2005-05-06 | Solvay Pharmaceuticals Gmbh | Pharmaceutical composition comprising a selective i1 imidazoline receptor agonist and an angiotensin ii receptor blocker |
US7232813B2 (en) * | 2004-01-12 | 2007-06-19 | Solvay Pharmaceuticals B.V. | Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders |
DK2470191T3 (da) * | 2009-08-24 | 2014-07-07 | Stealth Peptides Int Inc | Fremgangsmåder og præparater til forebyggelse eller behandling af oftalmiske tilstande |
-
2018
- 2018-01-31 PL PL424452A patent/PL424452A1/pl unknown
-
2019
- 2019-01-31 US US16/963,234 patent/US20210046097A1/en not_active Abandoned
- 2019-01-31 EP EP19747023.0A patent/EP3746106B1/en active Active
- 2019-01-31 HR HRP20240728TT patent/HRP20240728T1/hr unknown
- 2019-01-31 CA CA3088966A patent/CA3088966A1/en active Pending
- 2019-01-31 RS RS20240670A patent/RS65651B1/sr unknown
- 2019-01-31 TW TW108103768A patent/TWI762760B/zh active
- 2019-01-31 PL PL19747023.0T patent/PL3746106T3/pl unknown
- 2019-01-31 CN CN201980011177.2A patent/CN111757750A/zh active Pending
- 2019-01-31 WO PCT/PL2019/000012 patent/WO2019151882A1/en active Application Filing
- 2019-01-31 KR KR1020207025030A patent/KR20200116145A/ko not_active Application Discontinuation
- 2019-01-31 RU RU2020125048A patent/RU2758771C1/ru active
- 2019-01-31 MX MX2020007989A patent/MX2020007989A/es unknown
- 2019-09-10 ZA ZA2019/05959A patent/ZA201905959B/en unknown
-
2020
- 2020-07-12 IL IL275984A patent/IL275984A/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL191436B1 (pl) * | 1997-11-12 | 2006-05-31 | Solvay Pharm Gmbh | Podstawione ugrupowaniem kwasu fosfonowego pochodne benzazepinonu zawierające przy atomie N-ugrupowanie kwasu octowego, sposób ich wytwarzania i środki farmaceutyczne zawierające te związki |
EP1706121A1 (en) * | 2004-01-12 | 2006-10-04 | Solvay Pharmaceuticals B.V. | Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders |
WO2007056497A1 (en) * | 2005-11-07 | 2007-05-18 | Irm Llc | Compounds and compositions as ppar modulators |
Also Published As
Publication number | Publication date |
---|---|
IL275984A (en) | 2020-08-31 |
ZA201905959B (en) | 2021-07-28 |
TWI762760B (zh) | 2022-05-01 |
MX2020007989A (es) | 2020-09-09 |
EP3746106B1 (en) | 2024-03-27 |
HRP20240728T1 (hr) | 2024-08-30 |
EP3746106A4 (en) | 2021-11-03 |
WO2019151882A4 (en) | 2019-09-26 |
US20210046097A1 (en) | 2021-02-18 |
CN111757750A (zh) | 2020-10-09 |
EP3746106C0 (en) | 2024-03-27 |
RS65651B1 (sr) | 2024-07-31 |
PL3746106T3 (pl) | 2024-06-24 |
WO2019151882A1 (en) | 2019-08-08 |
TW201934536A (zh) | 2019-09-01 |
CA3088966A1 (en) | 2019-08-08 |
KR20200116145A (ko) | 2020-10-08 |
EP3746106A1 (en) | 2020-12-09 |
RU2758771C1 (ru) | 2021-11-01 |
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