HUP9802517A2 - Foszfonsavval helyettesített benzazepinon-N-ecetsav-származékok, eljárás ezek előállítására és az e vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Foszfonsavval helyettesített benzazepinon-N-ecetsav-származékok, eljárás ezek előállítására és az e vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9802517A2
HUP9802517A2 HU9802517A HUP9802517A HUP9802517A2 HU P9802517 A2 HUP9802517 A2 HU P9802517A2 HU 9802517 A HU9802517 A HU 9802517A HU P9802517 A HUP9802517 A HU P9802517A HU P9802517 A2 HUP9802517 A2 HU P9802517A2
Authority
HU
Hungary
Prior art keywords
benzazepinon
substituted
producing
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9802517A
Other languages
English (en)
Inventor
Jörg Meil
Dirk Thormählen
Harald Waldeck
Michael Wurl
Original Assignee
Solvay Pharmaceuticals Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh. filed Critical Solvay Pharmaceuticals Gmbh.
Publication of HU9802517D0 publication Critical patent/HU9802517D0/hu
Publication of HUP9802517A2 publication Critical patent/HUP9802517A2/hu
Publication of HUP9802517A3 publication Critical patent/HUP9802517A3/hu
Publication of HU221177B1 publication Critical patent/HU221177B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Az (I) általánős képletű vegyületek (mely képletben R1 jelentése hidrőgénatőm vagy valamely biőlabilis főszfőnsavésztertképező csőpőrt; R2 jelentése hidrőgénatőm vagy valamely biőlabilis főszfőnsavésztertképező csőpőrt; és R3 jelentése hidrőgénatőm vagy valamely biőlabilis karbőnsavésztertképező csőpőrt) és az (I) általánős képletű savak gyógyászatilagalkalmas sói NEP-gátló hatással rendelkeznek. ŕ
HU9802517A 1997-11-12 1998-11-02 Phosphonic acid-substituted benzazepinon-n-acetic acid derivatives, process for producing them and pharmaceutical compositions containing them HU221177B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19750002A DE19750002A1 (de) 1997-11-12 1997-11-12 Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (4)

Publication Number Publication Date
HU9802517D0 HU9802517D0 (en) 1998-12-28
HUP9802517A2 true HUP9802517A2 (hu) 1999-09-28
HUP9802517A3 HUP9802517A3 (en) 2000-06-28
HU221177B1 HU221177B1 (en) 2002-08-28

Family

ID=7848410

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802517A HU221177B1 (en) 1997-11-12 1998-11-02 Phosphonic acid-substituted benzazepinon-n-acetic acid derivatives, process for producing them and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US5952327A (hu)
EP (1) EP0916679B1 (hu)
JP (1) JP4162780B2 (hu)
KR (1) KR19990045100A (hu)
CN (1) CN1187361C (hu)
AR (1) AR009911A1 (hu)
AT (1) ATE228144T1 (hu)
AU (1) AU746907B2 (hu)
BR (1) BR9804582A (hu)
CA (1) CA2253997C (hu)
CZ (1) CZ296123B6 (hu)
DE (2) DE19750002A1 (hu)
DK (1) DK0916679T3 (hu)
DZ (1) DZ2652A1 (hu)
ES (1) ES2186961T3 (hu)
HK (1) HK1019338A1 (hu)
HU (1) HU221177B1 (hu)
ID (1) ID21393A (hu)
IL (1) IL126984A (hu)
NO (1) NO317640B1 (hu)
NZ (1) NZ332744A (hu)
PL (1) PL191436B1 (hu)
PT (1) PT916679E (hu)
RU (1) RU2211219C2 (hu)
SK (1) SK283233B6 (hu)
TR (1) TR199802289A2 (hu)
UA (1) UA60304C2 (hu)
ZA (1) ZA9810316B (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL367093A1 (en) * 2001-05-18 2005-02-21 Solvay Pharmaceuticals Gmbh Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments
IL162645A0 (en) * 2002-01-16 2005-11-20 Solvay Pharm Bv solid salts benzazepine compounds and their use inthe preparation of pharmaceuticals compounds
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
US7427611B2 (en) * 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
ATE406899T1 (de) * 2004-01-12 2008-09-15 Solvay Pharm Bv Neutrale endopeptidase (nep) und humane lösliche endopeptidase (hsep) hemmer für die prophylaxe und behandlung von neurodegenerativen erkrankungen
US7232813B2 (en) * 2004-01-12 2007-06-19 Solvay Pharmaceuticals B.V. Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
AU2005315608B2 (en) 2004-12-15 2011-03-31 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
WO2007102171A2 (en) * 2006-03-07 2007-09-13 Panacea Biotec Ltd Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition
US8198341B2 (en) 2008-12-18 2012-06-12 Icl-Ip America Inc. Method of making hydroxymethylphosphonate, polyurethane foam-forming compositions, polyurethane foam and articles made therefrom
US9441001B2 (en) 2012-10-17 2016-09-13 Icl-Ip America Inc. Method of making hydroxymethylphosphonate, polyurethane foam-forming compositions, polyurethane foam and articles made therefrom
US9523195B2 (en) 2014-06-09 2016-12-20 Johns Manville Wall insulation boards with non-halogenated fire retardant and insulated wall systems
US9528269B2 (en) 2014-06-09 2016-12-27 Johns Manville Roofing systems and roofing boards with non-halogenated fire retardant
US9815256B2 (en) 2014-06-09 2017-11-14 Johns Manville Foam boards including non-halogenated fire retardants
US9815966B2 (en) 2014-07-18 2017-11-14 Johns Manville Spray foams containing non-halogenated fire retardants
CN107383084A (zh) * 2017-06-14 2017-11-24 浙江嘉华化工有限公司 一种0‑乙基磷酸钠的制备方法
PL424452A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
PL424453A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors

Also Published As

Publication number Publication date
NO985262L (no) 1999-05-14
CN1187361C (zh) 2005-02-02
JPH11292886A (ja) 1999-10-26
EP0916679A1 (de) 1999-05-19
UA60304C2 (uk) 2003-10-15
NO317640B1 (no) 2004-11-29
PL191436B1 (pl) 2006-05-31
NO985262D0 (no) 1998-11-11
CZ356298A3 (cs) 1999-06-16
US5952327A (en) 1999-09-14
HUP9802517A3 (en) 2000-06-28
DZ2652A1 (fr) 2003-03-15
CN1217334A (zh) 1999-05-26
HU221177B1 (en) 2002-08-28
NZ332744A (en) 2000-06-23
HK1019338A1 (en) 2000-02-03
JP4162780B2 (ja) 2008-10-08
RU2211219C2 (ru) 2003-08-27
PL329635A1 (en) 1999-05-24
ZA9810316B (en) 1999-05-18
IL126984A (en) 2001-07-24
TR199802289A3 (tr) 1999-06-21
DK0916679T3 (da) 2002-12-16
HU9802517D0 (en) 1998-12-28
IL126984A0 (en) 1999-09-22
ES2186961T3 (es) 2003-05-16
DE19750002A1 (de) 1999-05-20
AR009911A1 (es) 2000-05-03
KR19990045100A (ko) 1999-06-25
SK151698A3 (en) 1999-05-07
CZ296123B6 (cs) 2006-01-11
ID21393A (id) 1999-06-03
CA2253997A1 (en) 1999-05-12
CA2253997C (en) 2009-05-12
TR199802289A2 (xx) 1999-06-21
AU746907B2 (en) 2002-05-02
PT916679E (pt) 2003-03-31
BR9804582A (pt) 2000-05-09
SK283233B6 (sk) 2003-04-01
AU9234498A (en) 2000-06-08
ATE228144T1 (de) 2002-12-15
EP0916679B1 (de) 2002-11-20
DE59806345D1 (de) 2003-01-02

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MM4A Lapse of definitive patent protection due to non-payment of fees