ES2191412T3 - Derivados de aminoacidos que contienen fluor. - Google Patents
Derivados de aminoacidos que contienen fluor.Info
- Publication number
- ES2191412T3 ES2191412T3 ES99901877T ES99901877T ES2191412T3 ES 2191412 T3 ES2191412 T3 ES 2191412T3 ES 99901877 T ES99901877 T ES 99901877T ES 99901877 T ES99901877 T ES 99901877T ES 2191412 T3 ES2191412 T3 ES 2191412T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- amino acids
- acids containing
- containing fluor
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Abstract
Un derivado de aminoácido que contiene flor representado por la fórmula **(Fórmula)** [en la que X1 representa un átomo de hidrógeno o un átomo de flúor, y R1 y R2 son iguales o diferentes y cada uno representa un átomo de hidrógeno o un grupo alquilo de 1 a 10 átomos de carbono], una sal del mismo farmacéuticamente permisible o un hidrato del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1544498 | 1998-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191412T3 true ES2191412T3 (es) | 2003-09-01 |
Family
ID=11888991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99901877T Expired - Lifetime ES2191412T3 (es) | 1998-01-28 | 1999-01-27 | Derivados de aminoacidos que contienen fluor. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6316498B1 (es) |
EP (1) | EP1052246B1 (es) |
KR (1) | KR100446892B1 (es) |
CN (1) | CN1182105C (es) |
AT (1) | ATE236118T1 (es) |
AU (1) | AU734812B2 (es) |
CA (1) | CA2318800C (es) |
DE (1) | DE69906492T2 (es) |
DK (1) | DK1052246T3 (es) |
ES (1) | ES2191412T3 (es) |
HK (1) | HK1036792A1 (es) |
PT (1) | PT1052246E (es) |
WO (1) | WO1999038839A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6333428B1 (en) | 1998-08-31 | 2001-12-25 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
JP4399932B2 (ja) | 1998-12-18 | 2010-01-20 | 大正製薬株式会社 | 中間体及びそれを用いた含フッ素アミノ酸化合物の製造方法 |
AU2002237717A1 (en) * | 2000-10-30 | 2002-05-27 | Annovis, Inc. | Method for modulation, stimulation, and inhibition of glutamate reuptake |
EP1351925A1 (en) | 2001-01-11 | 2003-10-15 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
EP1310480A1 (en) * | 2001-11-07 | 2003-05-14 | Eli Lilly & Company | Prodrugs of excitatory amino acids |
HUP0400620A3 (en) * | 2001-01-11 | 2012-09-28 | Lilly Co Eli | Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds |
KR20030083732A (ko) * | 2001-03-14 | 2003-10-30 | 다이쇼 세이야꾸 가부시끼가이샤 | 비시클로카르복실산 유도체의 제조 방법 |
US7456221B2 (en) | 2001-12-21 | 2008-11-25 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
WO2003104217A2 (en) | 2002-06-01 | 2003-12-18 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
EP1908492A4 (en) * | 2005-06-22 | 2008-12-10 | Ajinomoto Kk | METABOTROPIC GLUTAMATE RECEPTOR ACTIVATOR |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
ATE496906T1 (de) | 2007-09-14 | 2011-02-15 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyri inyl-2'-one |
CN101801930B (zh) * | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
BRPI0817101A2 (pt) | 2007-09-14 | 2017-05-09 | Addex Pharmaceuticals Sa | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
WO2009062676A2 (en) * | 2007-11-14 | 2009-05-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,2,4―트리아졸로[4,3―a]피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
CN103596933B (zh) | 2011-06-17 | 2016-03-23 | 伊莱利利公司 | 作为mglu2受体激动剂的双环(3.1.0)己烷-2,6-二羧酸衍生物 |
TWI602801B (zh) * | 2012-06-01 | 2017-10-21 | Taisho Pharmaceutical Co Ltd | Fluorinated amino acid prior to drug |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
NZ722385A (en) | 2014-01-21 | 2019-11-29 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
CN109999025A (zh) | 2014-01-21 | 2019-07-12 | 詹森药业有限公司 | 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途 |
CN105017048A (zh) * | 2015-07-01 | 2015-11-04 | 上海应用技术学院 | 一种含有四取代碳手性中心的α-氟烷基-α-氨基酸类化合物及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5661184A (en) | 1994-08-12 | 1997-08-26 | Eli Lilly And Company | Psychiatric agents |
PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
-
1999
- 1999-01-27 ES ES99901877T patent/ES2191412T3/es not_active Expired - Lifetime
- 1999-01-27 PT PT99901877T patent/PT1052246E/pt unknown
- 1999-01-27 DK DK99901877T patent/DK1052246T3/da active
- 1999-01-27 CA CA002318800A patent/CA2318800C/en not_active Expired - Fee Related
- 1999-01-27 KR KR10-2000-7008189A patent/KR100446892B1/ko not_active IP Right Cessation
- 1999-01-27 EP EP99901877A patent/EP1052246B1/en not_active Expired - Lifetime
- 1999-01-27 AU AU21835/99A patent/AU734812B2/en not_active Ceased
- 1999-01-27 US US09/601,131 patent/US6316498B1/en not_active Expired - Lifetime
- 1999-01-27 WO PCT/JP1999/000324 patent/WO1999038839A1/ja active IP Right Grant
- 1999-01-27 AT AT99901877T patent/ATE236118T1/de active
- 1999-01-27 DE DE69906492T patent/DE69906492T2/de not_active Expired - Lifetime
- 1999-01-27 CN CNB99804606XA patent/CN1182105C/zh not_active Expired - Fee Related
-
2001
- 2001-11-06 HK HK01107767A patent/HK1036792A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100446892B1 (ko) | 2004-09-04 |
EP1052246B1 (en) | 2003-04-02 |
AU734812B2 (en) | 2001-06-21 |
KR20010034418A (ko) | 2001-04-25 |
ATE236118T1 (de) | 2003-04-15 |
DK1052246T3 (da) | 2003-06-16 |
HK1036792A1 (en) | 2002-01-18 |
CN1295557A (zh) | 2001-05-16 |
AU2183599A (en) | 1999-08-16 |
EP1052246A4 (en) | 2001-11-07 |
CA2318800A1 (en) | 1999-08-25 |
US6316498B1 (en) | 2001-11-13 |
CN1182105C (zh) | 2004-12-29 |
PT1052246E (pt) | 2003-06-30 |
EP1052246A1 (en) | 2000-11-15 |
DE69906492T2 (de) | 2003-12-18 |
DE69906492D1 (de) | 2003-05-08 |
WO1999038839A1 (fr) | 1999-08-05 |
CA2318800C (en) | 2005-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2191412T3 (es) | Derivados de aminoacidos que contienen fluor. | |
ES2072779T3 (es) | Derivados aminoacidos anfoteros. | |
ES550716A0 (es) | Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables | |
NO20010836L (no) | Nitrogen-inneholdende heterosykliske karboksamidderivater eller salter derav og antivirale midler omfattende disse | |
HUP9802517A2 (hu) | Foszfonsavval helyettesített benzazepinon-N-ecetsav-származékok, eljárás ezek előállítására és az e vegyületeket tartalmazó gyógyászati készítmények | |
KR870000322A (ko) | 피리돈 카복실산 유도체의 제조방법 | |
HUP0100865A2 (hu) | Meta-azaciklusos csoporttal N-szubsztituált amino-benzoesav-vegyületek és származékaik mint integrin antagonista hatóanyagok, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DK55584D0 (da) | Hidtil ukendte carbacykliner,fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel | |
DE3570437D1 (en) | 1-hydroxy-1,1-diphosphonic-acid derivatives, process for their preparation and pharmaceutical preparations, especially for the treatment of bone tumours | |
CO4980887A1 (es) | Nueva 3,4-diariltiazolina-2-uno o 2-tiono derivados, sus metodos de preparacion y su uso terapeutico | |
HUP0300386A2 (hu) | Új (amino-propil)-metil-foszfinsavak | |
DK216388D0 (da) | 1,2,5,6-tetrahydropyridinderivater, deres fremstilling og laegemidler med indhold deraf | |
NO895002L (no) | Enzymhemmende aminosyrederivater. | |
TW355709B (en) | Quinoline carboxylic acid derivative | |
AU638465B2 (en) | Process for dyeing keratinous fibres based on monohydroxyindole and 5,6-disubstituted hydroxyindole and composition employed | |
ES8404976A1 (es) | Procedimiento para preparar nuevos derivados de encefalina. | |
MY126743A (en) | Aminoethylphenoxyacetic acid derivatives and agents for relieving pain and promoting the removal of calculi in urolithiasis | |
DK282285A (da) | Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser | |
CO5021214A1 (es) | Derivado del acido 2-metilpropionico y composicion farmaceutica que lo contiene | |
HRP20010885B1 (en) | Ethanesulfonyl-piperidine derivatives | |
EA200001107A1 (ru) | ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ | |
YU12384A (en) | Process for making amino derivatives of piridazine, substituted in position 6 with heterocyclic or acyclic compound with effect on the central neurosystem | |
ES8401761A1 (es) | Un procedimiento para la preparacion de derivados de 1-(3,4,5-trimetoxicinamoil)-4-aminocarboniletil-piperazina sustituidos. | |
DE69629664D1 (de) | Wässrige zusammensetzungen mit ciprofloxacin, verfahren zu deren herstellung und deren verwendung | |
NO932002L (no) | Nye tiosemikarbazonsyreestere |