KR870000322A - 피리돈 카복실산 유도체의 제조방법 - Google Patents

피리돈 카복실산 유도체의 제조방법 Download PDF

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Publication number
KR870000322A
KR870000322A KR1019860005232A KR860005232A KR870000322A KR 870000322 A KR870000322 A KR 870000322A KR 1019860005232 A KR1019860005232 A KR 1019860005232A KR 860005232 A KR860005232 A KR 860005232A KR 870000322 A KR870000322 A KR 870000322A
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South Korea
Prior art keywords
group
lower alkyl
hydrogen atom
alkyl group
sup
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KR1019860005232A
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English (en)
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KR930005002B1 (ko
Inventor
구니요시 마수자와
세이꼬 수쮸
게이지 히라이
다까요시 이시자끼
Original Assignee
교린 세이야꾸 가부시끼가이샤
하기하라 히데
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Publication of KR870000322A publication Critical patent/KR870000322A/ko
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Publication of KR930005002B1 publication Critical patent/KR930005002B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음.

Description

피리돈 카복실산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(II)의 화합물을 일반식(III)의 화합물과 축합시킴을 특징으로 하여, 일반식(I)의 화합물, 이의 수화물 및 약학적으로 허용되는 산부가 또는 알칼리 염을 제조하는 방법.
    상기식에서, R2은 수소원자 또는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, X는 할로겐 원자이고, R3는 수소원자, 저급알킬기, 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.
  2. 일반식(IV)의 화합물을 가수분해시킴을 특징으로 하여, R이 수소원자인, 제1항에서 정의된 일반식(I)의 화합물의 제조하는 방법.
    상기식에서, A는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, R2는 저급알킬기, 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.
  3. 일반식(V)의 화합물을 틸아실화(deacylating)시킴을 특징으로 하여, R2가 수소원자인, 제1항에서 정의된 일반식(I)의 화합물을 제조하는 방법.
    상기식에서, R은 수소원자 또는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, R3는 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019860005232A 1985-06-28 1986-06-28 피리돈카복실산 유도체의 제조방법 KR930005002B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP85141813 1985-06-28
JP60141813A JPH0635457B2 (ja) 1985-06-28 1985-06-28 ピリドンカルボン酸誘導体およびその製造方法
JP141813 1985-06-28

Publications (2)

Publication Number Publication Date
KR870000322A true KR870000322A (ko) 1987-02-17
KR930005002B1 KR930005002B1 (ko) 1993-06-11

Family

ID=15300723

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860005232A KR930005002B1 (ko) 1985-06-28 1986-06-28 피리돈카복실산 유도체의 제조방법

Country Status (16)

Country Link
US (1) US4753953A (ko)
EP (1) EP0208210B1 (ko)
JP (1) JPH0635457B2 (ko)
KR (1) KR930005002B1 (ko)
CN (1) CN1010312B (ko)
AT (1) ATE57699T1 (ko)
AU (1) AU589427B2 (ko)
CA (1) CA1262349A (ko)
DE (1) DE3675087D1 (ko)
DK (1) DK171330B1 (ko)
ES (1) ES2000185A6 (ko)
FI (1) FI85697C (ko)
HU (1) HU208128B (ko)
MX (1) MX162950B (ko)
NO (1) NO166126C (ko)
PT (1) PT82854B (ko)

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DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
DE3639465A1 (de) * 1986-11-18 1988-05-19 Hoechst Ag Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika
JP2603638B2 (ja) * 1987-07-08 1997-04-23 第一製薬株式会社 光学異性体の分析法及び分取法
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
CA1332605C (en) * 1988-10-03 1994-10-18 Yasuhiro Nishitani Pyridonecarboxylic acids
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
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FI96313C (fi) * 1990-11-28 1996-06-10 Daiichi Seiyaku Co Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
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US7977327B2 (en) 2004-05-13 2011-07-12 Daiichi Sankyo Company, Limited Substituted pyrrolidine derivative
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WO2008143343A1 (ja) 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
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Also Published As

Publication number Publication date
NO862621D0 (no) 1986-06-27
NO862621L (no) 1986-12-29
PT82854B (pt) 1988-05-27
NO166126B (no) 1991-02-25
AU5919086A (en) 1987-01-08
DK306586D0 (da) 1986-06-27
CA1262349A (en) 1989-10-17
CN1010312B (zh) 1990-11-07
FI862757A0 (fi) 1986-06-27
FI85697B (fi) 1992-02-14
AU589427B2 (en) 1989-10-12
JPS624284A (ja) 1987-01-10
JPH0635457B2 (ja) 1994-05-11
HU208128B (en) 1993-08-30
DK306586A (da) 1986-12-29
FI85697C (fi) 1992-05-25
ES2000185A6 (es) 1988-01-01
MX162950B (es) 1991-07-22
DK171330B1 (da) 1996-09-09
EP0208210A1 (en) 1987-01-14
US4753953A (en) 1988-06-28
NO166126C (no) 1991-06-05
HUT43051A (en) 1987-09-28
CN86104479A (zh) 1987-02-04
ATE57699T1 (de) 1990-11-15
DE3675087D1 (de) 1990-11-29
EP0208210B1 (en) 1990-10-24
KR930005002B1 (ko) 1993-06-11
PT82854A (en) 1986-07-01
FI862757A (fi) 1986-12-29

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