KR870000322A - 피리돈 카복실산 유도체의 제조방법 - Google Patents
피리돈 카복실산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR870000322A KR870000322A KR1019860005232A KR860005232A KR870000322A KR 870000322 A KR870000322 A KR 870000322A KR 1019860005232 A KR1019860005232 A KR 1019860005232A KR 860005232 A KR860005232 A KR 860005232A KR 870000322 A KR870000322 A KR 870000322A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- lower alkyl
- hydrogen atom
- alkyl group
- sup
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
- Photoreceptors In Electrophotography (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 일반식(II)의 화합물을 일반식(III)의 화합물과 축합시킴을 특징으로 하여, 일반식(I)의 화합물, 이의 수화물 및 약학적으로 허용되는 산부가 또는 알칼리 염을 제조하는 방법.상기식에서, R2은 수소원자 또는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, X는 할로겐 원자이고, R3는 수소원자, 저급알킬기, 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.
- 일반식(IV)의 화합물을 가수분해시킴을 특징으로 하여, R이 수소원자인, 제1항에서 정의된 일반식(I)의 화합물의 제조하는 방법.상기식에서, A는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, R2는 저급알킬기, 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.
- 일반식(V)의 화합물을 틸아실화(deacylating)시킴을 특징으로 하여, R2가 수소원자인, 제1항에서 정의된 일반식(I)의 화합물을 제조하는 방법.상기식에서, R은 수소원자 또는 저급알킬기이고, R1은 저급알킬기, 시클로알킬기 또는 할로알킬기이고, Y는 수소원자 또는 할로겐 원자이거나, Y와 R1은 함께이고, R3는 알콕시카보닐기 또는 아실기이며, n은 0 또는 1이다.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP85141813 | 1985-06-28 | ||
JP60141813A JPH0635457B2 (ja) | 1985-06-28 | 1985-06-28 | ピリドンカルボン酸誘導体およびその製造方法 |
JP141813 | 1985-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870000322A true KR870000322A (ko) | 1987-02-17 |
KR930005002B1 KR930005002B1 (ko) | 1993-06-11 |
Family
ID=15300723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860005232A KR930005002B1 (ko) | 1985-06-28 | 1986-06-28 | 피리돈카복실산 유도체의 제조방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4753953A (ko) |
EP (1) | EP0208210B1 (ko) |
JP (1) | JPH0635457B2 (ko) |
KR (1) | KR930005002B1 (ko) |
CN (1) | CN1010312B (ko) |
AT (1) | ATE57699T1 (ko) |
AU (1) | AU589427B2 (ko) |
CA (1) | CA1262349A (ko) |
DE (1) | DE3675087D1 (ko) |
DK (1) | DK171330B1 (ko) |
ES (1) | ES2000185A6 (ko) |
FI (1) | FI85697C (ko) |
HU (1) | HU208128B (ko) |
MX (1) | MX162950B (ko) |
NO (1) | NO166126C (ko) |
PT (1) | PT82854B (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
US4692454A (en) * | 1986-02-03 | 1987-09-08 | Warner-Lambert Company | Opthalmic use of quinolone antibiotics |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
JPS62205060A (ja) * | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8位置換キノロンカルボン酸誘導体 |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
DE3639465A1 (de) * | 1986-11-18 | 1988-05-19 | Hoechst Ag | Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika |
JP2603638B2 (ja) * | 1987-07-08 | 1997-04-23 | 第一製薬株式会社 | 光学異性体の分析法及び分取法 |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
CA1332605C (en) * | 1988-10-03 | 1994-10-18 | Yasuhiro Nishitani | Pyridonecarboxylic acids |
DE3918544A1 (de) * | 1989-06-07 | 1990-12-13 | Bayer Ag | Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren |
US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
MY109714A (en) * | 1990-10-18 | 1997-04-30 | Daiichi Seiyaku Co | Process for preparing 8-chloroquinolone derivatives |
FI96313C (fi) * | 1990-11-28 | 1996-06-10 | Daiichi Seiyaku Co | Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi |
KR950014567B1 (ko) * | 1991-08-01 | 1995-12-08 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
TW252107B (ko) * | 1993-08-27 | 1995-07-21 | Hokuriku Pharmacetical Co Ltd | |
US5859026A (en) * | 1995-01-24 | 1999-01-12 | Hokuriku Seiyaku Co., Ltd. | Quinoline carboxylic acid |
SI1666477T1 (sl) | 2003-09-10 | 2013-10-30 | Kyorin Pharmaceutical Co., Ltd. | Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline |
EP1712554A1 (en) * | 2004-02-02 | 2006-10-18 | Daiichi Pharmaceutical Co., Ltd. | Pyridobenzoxazine derivative |
US7977327B2 (en) | 2004-05-13 | 2011-07-12 | Daiichi Sankyo Company, Limited | Substituted pyrrolidine derivative |
US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
WO2008143343A1 (ja) | 2007-05-24 | 2008-11-27 | Kyorin Pharmaceutical Co., Ltd. | 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
FR2961207B1 (fr) * | 2010-06-09 | 2013-01-18 | Oreal | Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1175836A (en) * | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
US4620007A (en) * | 1980-09-03 | 1986-10-28 | Bayer Aktiengesellschaft | 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
JPS5788183A (en) * | 1980-11-21 | 1982-06-01 | Dai Ichi Seiyaku Co Ltd | Pyridobenzoxazine derivative |
JPS5872589A (ja) * | 1981-10-28 | 1983-04-30 | Dai Ichi Seiyaku Co Ltd | ピリド〔1,2,3−de〕〔1,4〕ベンゾオキサジン誘導体 |
PH22140A (en) * | 1982-06-29 | 1988-06-01 | Daiichi Seiyaku Co | Tricyclic compounds |
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS60260577A (ja) * | 1984-06-06 | 1985-12-23 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン誘導体 |
CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
US4542133A (en) * | 1984-04-26 | 1985-09-17 | Abbott Laboratories | Methylenedioxy quino-benoxazine derivatives and antibacterial use |
JPH0665676B2 (ja) * | 1984-04-26 | 1994-08-24 | アボツト ラボラトリーズ | キノリン‐ベノキサジン抗菌性化合物 |
DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4604401A (en) * | 1984-07-20 | 1986-08-05 | Warner-Lambert Company | Antibacterial agents III |
JPH0670032B2 (ja) * | 1984-11-22 | 1994-09-07 | 大日本製薬株式会社 | アミノピロリジン誘導体、そのエステルおよびその塩 |
JPS61137885A (ja) * | 1984-12-08 | 1986-06-25 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン誘導体、そのエステルおよびその塩 |
JPS61148179A (ja) * | 1984-12-20 | 1986-07-05 | Dainippon Pharmaceut Co Ltd | 新規ナフチリジン誘導体、そのエステルおよびその塩 |
US4578473A (en) * | 1985-04-15 | 1986-03-25 | Warner-Lambert Company | Process for quinoline-3-carboxylic acid antibacterial agents |
AU585995B2 (en) * | 1985-06-20 | 1989-06-29 | Daiichi Pharmaceutical Co., Ltd. | Optically active pyridobenzoxazine derivatives and intermediates thereof |
JPS62205060A (ja) * | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8位置換キノロンカルボン酸誘導体 |
-
1985
- 1985-06-28 JP JP60141813A patent/JPH0635457B2/ja not_active Expired - Fee Related
-
1986
- 1986-06-20 US US06/876,420 patent/US4753953A/en not_active Expired - Lifetime
- 1986-06-23 HU HU862626A patent/HU208128B/hu not_active IP Right Cessation
- 1986-06-23 AU AU59190/86A patent/AU589427B2/en not_active Ceased
- 1986-06-25 CA CA000512440A patent/CA1262349A/en not_active Expired
- 1986-06-26 EP EP86108728A patent/EP0208210B1/en not_active Expired - Lifetime
- 1986-06-26 DE DE8686108728T patent/DE3675087D1/de not_active Expired - Lifetime
- 1986-06-26 PT PT82854A patent/PT82854B/pt not_active IP Right Cessation
- 1986-06-26 AT AT86108728T patent/ATE57699T1/de not_active IP Right Cessation
- 1986-06-27 DK DK306586A patent/DK171330B1/da not_active IP Right Cessation
- 1986-06-27 CN CN86104479A patent/CN1010312B/zh not_active Expired
- 1986-06-27 ES ES8600048A patent/ES2000185A6/es not_active Expired
- 1986-06-27 FI FI862757A patent/FI85697C/fi active IP Right Grant
- 1986-06-27 MX MX2967A patent/MX162950B/es unknown
- 1986-06-27 NO NO862621A patent/NO166126C/no not_active IP Right Cessation
- 1986-06-28 KR KR1019860005232A patent/KR930005002B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO862621D0 (no) | 1986-06-27 |
NO862621L (no) | 1986-12-29 |
PT82854B (pt) | 1988-05-27 |
NO166126B (no) | 1991-02-25 |
AU5919086A (en) | 1987-01-08 |
DK306586D0 (da) | 1986-06-27 |
CA1262349A (en) | 1989-10-17 |
CN1010312B (zh) | 1990-11-07 |
FI862757A0 (fi) | 1986-06-27 |
FI85697B (fi) | 1992-02-14 |
AU589427B2 (en) | 1989-10-12 |
JPS624284A (ja) | 1987-01-10 |
JPH0635457B2 (ja) | 1994-05-11 |
HU208128B (en) | 1993-08-30 |
DK306586A (da) | 1986-12-29 |
FI85697C (fi) | 1992-05-25 |
ES2000185A6 (es) | 1988-01-01 |
MX162950B (es) | 1991-07-22 |
DK171330B1 (da) | 1996-09-09 |
EP0208210A1 (en) | 1987-01-14 |
US4753953A (en) | 1988-06-28 |
NO166126C (no) | 1991-06-05 |
HUT43051A (en) | 1987-09-28 |
CN86104479A (zh) | 1987-02-04 |
ATE57699T1 (de) | 1990-11-15 |
DE3675087D1 (de) | 1990-11-29 |
EP0208210B1 (en) | 1990-10-24 |
KR930005002B1 (ko) | 1993-06-11 |
PT82854A (en) | 1986-07-01 |
FI862757A (fi) | 1986-12-29 |
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