WO2008143343A1 - １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 - Google Patents

１４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 Download PDF

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Publication number
WO2008143343A1
WO2008143343A1 PCT/JP2008/059535 JP2008059535W WO2008143343A1 WO 2008143343 A1 WO2008143343 A1 WO 2008143343A1 JP 2008059535 W JP2008059535 W JP 2008059535W WO 2008143343 A1 WO2008143343 A1 WO 2008143343A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituent
mutilin derivative
carboxylic acid
aromatic ring
heterocyclic aromatic
Prior art date
Application number
PCT/JP2008/059535
Other languages
English (en)
French (fr)
Inventor
Yasumichi Fukuda
Masanori Takadoi
Yoshikazu Asahina
Taro Sato
Haruaki Kurasaki
Hiroyuki Ebisu
Masaya Takei
Hideyuki Fukuda
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to US12/451,656 priority Critical patent/US8222407B2/en
Priority to EP08764581A priority patent/EP2149571A4/en
Priority to CA002688008A priority patent/CA2688008A1/en
Priority to JP2009515280A priority patent/JP5322927B2/ja
Publication of WO2008143343A1 publication Critical patent/WO2008143343A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Abstract

【課題】各種耐性菌を含むグラム陽性菌、およびグラム陰性菌に対して強力かつ幅広い抗菌作用を示し、感染症治療薬としての用途が期待されるムチリンの新規類縁体である14位置換誘導体を提供する。 【解決手段】　下記一般式（１） 【化１】 で表されるムチリン誘導体又は薬学的に許容されるそれらの付加塩類。
PCT/JP2008/059535 2007-05-24 2008-05-23 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 WO2008143343A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/451,656 US8222407B2 (en) 2007-05-24 2008-05-23 Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
EP08764581A EP2149571A4 (en) 2007-05-24 2008-05-23 MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
CA002688008A CA2688008A1 (en) 2007-05-24 2008-05-23 Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
JP2009515280A JP5322927B2 (ja) 2007-05-24 2008-05-23 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007137473 2007-05-24
JP2007-137473 2007-05-24

Publications (1)

Publication Number Publication Date
WO2008143343A1 true WO2008143343A1 (ja) 2008-11-27

Family

ID=40032025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059535 WO2008143343A1 (ja) 2007-05-24 2008-05-23 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体

Country Status (5)

Country Link
US (1) US8222407B2 (ja)
EP (1) EP2149571A4 (ja)
JP (1) JP5322927B2 (ja)
CA (1) CA2688008A1 (ja)
WO (1) WO2008143343A1 (ja)

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JP2010100582A (ja) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
JP2016084350A (ja) * 2015-12-10 2016-05-19 東京応化工業株式会社 化合物
US9701628B2 (en) 2014-01-22 2017-07-11 Nabriva Therapeutics Ag 12-epi pleuromutilins

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EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CN102558004B (zh) * 2011-12-12 2013-11-06 温州大学 一种s-(4-甲苯基)苯磺酸酯的化学合成方法
CN102531983B (zh) * 2011-12-12 2013-07-17 温州大学 一种s-苯基-4-甲苯磺酸酯的化学合成方法
RU2677639C2 (ru) 2012-07-13 2019-01-18 Шин Ниппон Биомедикал Лэбораториз, Лтд. Хиральный адъювант нуклеиновой кислоты
BR112015000784A8 (pt) 2012-07-13 2018-04-03 Wave Life Sciences Japan Grupo auxiliar assimétrico
PL2872147T3 (pl) 2012-07-13 2023-09-25 Wave Life Sciences Ltd. Sposób wytwarzania chiralnych oligonukleotydów
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
CN103214406B (zh) * 2013-05-15 2014-06-18 竺叶洪 一种苯磺酸酯化合物的制备方法
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
WO2018058534A1 (zh) 2016-09-30 2018-04-05 华南农业大学 一种具有2-氨基苯巯醇侧链的截短侧耳素衍生物及其制备方法和用途
CN114478150B (zh) * 2022-01-22 2024-04-09 浙江工业大学 一种s-氘代甲基-芳基磺酰硫酯类化合物及其合成方法与应用

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