WO2008155615A3 - An improved process for the preparation of cephalosporin antibiotic - Google Patents

An improved process for the preparation of cephalosporin antibiotic Download PDF

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Publication number
WO2008155615A3
WO2008155615A3 PCT/IB2008/001518 IB2008001518W WO2008155615A3 WO 2008155615 A3 WO2008155615 A3 WO 2008155615A3 IB 2008001518 W IB2008001518 W IB 2008001518W WO 2008155615 A3 WO2008155615 A3 WO 2008155615A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
cephalosporin antibiotic
esters
salt
Prior art date
Application number
PCT/IB2008/001518
Other languages
French (fr)
Other versions
WO2008155615A2 (en
Inventor
Sreedhar Gedi
Kamma Ramakrishna
Palanisamy Senth Udayampalayam
Original Assignee
Orchid Chemicals & Pharm Ltd
Sreedhar Gedi
Kamma Ramakrishna
Palanisamy Senth Udayampalayam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Sreedhar Gedi, Kamma Ramakrishna, Palanisamy Senth Udayampalayam filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2008155615A2 publication Critical patent/WO2008155615A2/en
Publication of WO2008155615A3 publication Critical patent/WO2008155615A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Abstract

The present invention provides a process for the preparation of the compound of formula (I) and its salt and esters. More particularly, this present invention relates to an improved process for the preparation Cefcapene of formula (I) and its salt and esters.
PCT/IB2008/001518 2007-06-18 2008-06-13 An improved process for the preparation of cephalosporin antibiotic WO2008155615A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1262CH2007 2007-06-18
IN1262/CHE/2007 2007-06-18

Publications (2)

Publication Number Publication Date
WO2008155615A2 WO2008155615A2 (en) 2008-12-24
WO2008155615A3 true WO2008155615A3 (en) 2009-02-19

Family

ID=40156747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001518 WO2008155615A2 (en) 2007-06-18 2008-06-13 An improved process for the preparation of cephalosporin antibiotic

Country Status (1)

Country Link
WO (1) WO2008155615A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747344B (en) * 2009-12-22 2012-07-04 山东润泽制药有限公司 Synthesis Method of cefcapene pivoxil hydrochloride
CN101851249A (en) * 2010-06-18 2010-10-06 浙江华方药业有限责任公司 Method for preparing cefcapene pivoxil hydrochloride
CN102485727B (en) * 2010-12-02 2014-05-07 石药集团中奇制药技术（石家庄）有限公司 Cefcapene pivoxil hydrochloride and method for preparing its intermediate
CN102796117B (en) * 2011-05-27 2016-08-10 江苏豪森药业集团有限公司 A kind of preparation method of Method of cefcapene pivoxil hydrochloride
CN103087080B (en) * 2011-11-03 2016-08-31 石药集团中奇制药技术（石家庄）有限公司 The preparation method of a kind of Method of cefcapene pivoxil hydrochloride and synthetic intermediate thereof
CN103374595B (en) * 2012-04-16 2015-07-15 重庆圣华曦药业股份有限公司 Method for preparing beta-lactam derivative through enzymatic reaction
CN105131017B (en) * 2015-09-09 2017-07-25 山东罗欣药业集团股份有限公司 A kind of preparation method of Method of cefcapene pivoxil hydrochloride
CN105254649B (en) * 2015-11-02 2018-06-26 湖北凌晟药业有限公司 A kind of preparation method of Method of cefcapene pivoxil hydrochloride
CN105198906B (en) * 2015-11-02 2018-04-03 马晓维 The preparation method of Method of cefcapene pivoxil hydrochloride
CN105330627B (en) * 2015-11-24 2018-03-16 辽宁大学 The method that high selectivity prepares SMIA
CN106366098A (en) * 2016-08-17 2017-02-01 陕西顿斯制药有限公司 Cefuroxime sodium compound prepared through advanced on-line process control technology and preparation thereof
CN111004255A (en) * 2019-12-30 2020-04-14 浙江东邦药业有限公司 Preparation method of cefcapene lactone compound or hydrochloride thereof
CN112745338B (en) * 2020-12-30 2022-08-16 山东金城昆仑药业有限公司 Method for eliminating lactone impurities in cefuroxime acid
CN113025679B (en) * 2021-03-17 2023-04-28 石药集团内蒙古中诺药业有限公司 Enzymatic preparation process of cefcapene precursor acid of t-butyloxycarbonyl
CN114014877A (en) * 2021-11-29 2022-02-08 湖北凌晟药业有限公司 Method for synthesizing cefcapene acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602012A (en) * 1984-01-03 1986-07-22 Glaxo Group Limited Cephalosporin antibiotics
GB2173194A (en) * 1985-03-29 1986-10-08 Shionogi & Co 7-beta-(2-(amino-4-thiazolyl)-2-alkenoylamino)-3-cephem-4-carboxylic acid ester derivativess
WO2004050663A2 (en) * 2002-12-05 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefuroxime sodium

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602012A (en) * 1984-01-03 1986-07-22 Glaxo Group Limited Cephalosporin antibiotics
GB2173194A (en) * 1985-03-29 1986-10-08 Shionogi & Co 7-beta-(2-(amino-4-thiazolyl)-2-alkenoylamino)-3-cephem-4-carboxylic acid ester derivativess
WO2004050663A2 (en) * 2002-12-05 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefuroxime sodium

Also Published As

Publication number Publication date
WO2008155615A2 (en) 2008-12-24

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