WO2007083187A3 - An improved process for the preparation of monobactam antibiotic - Google Patents

An improved process for the preparation of monobactam antibiotic Download PDF

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Publication number
WO2007083187A3
WO2007083187A3 PCT/IB2006/003783 IB2006003783W WO2007083187A3 WO 2007083187 A3 WO2007083187 A3 WO 2007083187A3 IB 2006003783 W IB2006003783 W IB 2006003783W WO 2007083187 A3 WO2007083187 A3 WO 2007083187A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
monobactam antibiotic
formula
monobactam
Prior art date
Application number
PCT/IB2006/003783
Other languages
French (fr)
Other versions
WO2007083187A2 (en
Inventor
Udayampalayam Pal Senthilkumar
Jitendra Bhagwandas Kevat
Andrew Gnanaprakasam
Chinnian Jeyaraman Magesh
Manohar Puppala
Venugopal Sivasankaran
Original Assignee
Orchid Chemicals & Pharm Ltd
Udayampalayam Pal Senthilkumar
Jitendra Bhagwandas Kevat
Andrew Gnanaprakasam
Chinnian Jeyaraman Magesh
Manohar Puppala
Venugopal Sivasankaran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Udayampalayam Pal Senthilkumar, Jitendra Bhagwandas Kevat, Andrew Gnanaprakasam, Chinnian Jeyaraman Magesh, Manohar Puppala, Venugopal Sivasankaran filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2007083187A2 publication Critical patent/WO2007083187A2/en
Publication of WO2007083187A3 publication Critical patent/WO2007083187A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to the process for the preparation of monobactam antibiotic of formula (I). More particularly, the present invention relates to the preparation of Aztreonam of formula (I) from its precursor, tertiary butyl ester of Aztreonam of formula (II).
PCT/IB2006/003783 2006-01-16 2006-12-28 An improved process for the preparation of monobactam antibiotic WO2007083187A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN65CH2006 2006-01-16
IN65/CHE/2006 2006-01-16

Publications (2)

Publication Number Publication Date
WO2007083187A2 WO2007083187A2 (en) 2007-07-26
WO2007083187A3 true WO2007083187A3 (en) 2008-06-12

Family

ID=38287984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003783 WO2007083187A2 (en) 2006-01-16 2006-12-28 An improved process for the preparation of monobactam antibiotic

Country Status (1)

Country Link
WO (1) WO2007083187A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2606901A1 (en) 2005-05-09 2006-11-16 Sicor Inc. Process for making aztreonam
CN102127068B (en) * 2010-12-31 2012-08-29 山西普德药业股份有限公司 Method for synthesizing aztreonam compound
CN103570707B (en) * 2012-07-21 2016-03-09 重庆圣华曦药业股份有限公司 A kind of synthetic method of aztreonam of improvement
CN105085511B (en) * 2015-05-29 2018-04-06 石药集团中诺药业（石家庄）有限公司 A kind of new aztreonam compound
CN106520857B (en) * 2016-08-25 2020-01-07 艾美科健（中国）生物医药有限公司 Method for synthesizing aztreonam by enzyme method
JP6991345B2 (en) * 2017-10-02 2022-01-12 アリクサ ファーマシューティカルズ、インコーポレイテッド Aztreonam derivatives and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL178521B1 (en) * 1995-10-24 2000-05-31 Inst Biotechnologii I Antybiot Method of obtaining azthreoname of very high purity
WO2004013133A1 (en) * 2002-08-05 2004-02-12 TEVA Gyógyszergyár Részvénytársaság Preparation of aztreonam

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL178521B1 (en) * 1995-10-24 2000-05-31 Inst Biotechnologii I Antybiot Method of obtaining azthreoname of very high purity
WO2004013133A1 (en) * 2002-08-05 2004-02-12 TEVA Gyógyszergyár Részvénytársaság Preparation of aztreonam

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] accession no. STN Database accession no. (134:252200) *

Also Published As

Publication number Publication date
WO2007083187A2 (en) 2007-07-26

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