WO2008105515A1 - 新規なヒドロキサム酸誘導体 - Google Patents
新規なヒドロキサム酸誘導体 Download PDFInfo
- Publication number
- WO2008105515A1 WO2008105515A1 PCT/JP2008/053573 JP2008053573W WO2008105515A1 WO 2008105515 A1 WO2008105515 A1 WO 2008105515A1 JP 2008053573 W JP2008053573 W JP 2008053573W WO 2008105515 A1 WO2008105515 A1 WO 2008105515A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid derivative
- hydroxamic acid
- novel hydroxamic
- disclosed
- novel
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本発明の課題は、LpxC
阻害作用に基づいて、緑膿菌等のグラム陰性細菌及びその薬剤耐性菌に対して強い抗菌活性を示し、医薬品として有用な新規な化合物を提供することである。一般式(1)で表されるヒドロキサム酸誘導体又はその薬学的に許容される塩を提供する。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009501309A JP5227304B2 (ja) | 2007-02-28 | 2008-02-28 | 新規なヒドロキサム酸誘導体 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-050739 | 2007-02-28 | ||
JP2007050739 | 2007-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008105515A1 true WO2008105515A1 (ja) | 2008-09-04 |
Family
ID=39721337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/053573 WO2008105515A1 (ja) | 2007-02-28 | 2008-02-28 | 新規なヒドロキサム酸誘導体 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5227304B2 (ja) |
WO (1) | WO2008105515A1 (ja) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009084543A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
WO2010024356A1 (ja) * | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン-n-オキシドを有する新規ヒドロキサム酸誘導体 |
WO2010100475A1 (en) * | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
WO2013170165A1 (en) * | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
US8624034B2 (en) | 2011-03-07 | 2014-01-07 | Pfizer Inc. | Fluoro-pyridinone derivatives useful as antibacterial agents |
US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
US20140139786A1 (en) * | 2012-11-21 | 2014-05-22 | Merck Patent Gmbh | Polymerisable compounds and the use thereof in liquid-crystal displays |
US8748466B2 (en) | 2011-04-08 | 2014-06-10 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
US8809333B2 (en) | 2011-04-08 | 2014-08-19 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
US20150057260A1 (en) * | 2013-08-22 | 2015-02-26 | Genentech, Inc. | Alkynyl alcohols and methods of use |
WO2016039433A1 (ja) * | 2014-09-12 | 2016-03-17 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体またはその塩を含有する医薬組成物 |
JP2016508487A (ja) * | 2013-01-28 | 2016-03-22 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 金属酵素阻害剤化合物 |
US9617256B2 (en) | 2007-06-12 | 2017-04-11 | Achaogen, Inc. | Antibacterial agents |
WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
US9908851B2 (en) | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
US10189786B2 (en) | 2013-08-16 | 2019-01-29 | Duke University | Antibacterial compounds |
CN109574980A (zh) * | 2018-11-28 | 2019-04-05 | 云南大学 | 基于罗丹明衍生物检测一氧化氮的荧光探针分子、制备及用途 |
WO2019068613A1 (en) | 2017-10-02 | 2019-04-11 | Boehringer Ingelheim International Gmbh | NOVEL [1,6] NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8 / CDK19 INHIBITORS |
US10550117B2 (en) | 2016-08-24 | 2020-02-04 | Genentech, Inc. | 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use |
US10597361B2 (en) | 2010-09-03 | 2020-03-24 | Duke University | Ethynylbenzene derivatives |
US10647664B2 (en) | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
CN111867600A (zh) * | 2018-03-15 | 2020-10-30 | 辉瑞大药厂 | 用作抗菌剂的吡啶酮和嘧啶酮磷酸盐和硼酸盐 |
CN115448919A (zh) * | 2022-10-31 | 2022-12-09 | 滨州医学院附属医院 | 一种海洋来源的萘啶类抗炎活性化合物及其制备方法 |
EP4140994A1 (en) * | 2021-08-26 | 2023-03-01 | Idemitsu Kosan Co., Ltd. | Compound, material for an organic electroluminescence device and an organic electroluminescence device comprising the compound |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870712A (en) * | 1972-03-17 | 1975-03-11 | Lilly Co Eli | Cinchoninic acid derivatives |
JP2006519772A (ja) * | 2003-01-08 | 2006-08-31 | カイロン コーポレイション | 抗菌剤 |
-
2008
- 2008-02-28 JP JP2009501309A patent/JP5227304B2/ja not_active Expired - Fee Related
- 2008-02-28 WO PCT/JP2008/053573 patent/WO2008105515A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870712A (en) * | 1972-03-17 | 1975-03-11 | Lilly Co Eli | Cinchoninic acid derivatives |
JP2006519772A (ja) * | 2003-01-08 | 2006-08-31 | カイロン コーポレイション | 抗菌剤 |
Non-Patent Citations (2)
Title |
---|
KADAM R.U. ET AL.: "Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 19, 2006, pages 5136 - 5143, XP005611710 * |
KLINE T. ET AL.: "Potent, Novel in Vitro Inhibitors of the Pseudomonas aeruginosa Deacetylase LpxC", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 14, 2002, pages 3112 - 3129, XP008045411 * |
Cited By (43)
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---|---|---|---|---|
US9617256B2 (en) | 2007-06-12 | 2017-04-11 | Achaogen, Inc. | Antibacterial agents |
WO2009084543A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
US8945724B2 (en) | 2007-12-27 | 2015-02-03 | Idemitsu Kosan Co., Ltd. | Nitrogen-containing heterocyclic derivative and organic electroluminescent device using the same |
WO2010024356A1 (ja) * | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン-n-オキシドを有する新規ヒドロキサム酸誘導体 |
US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
US9340493B2 (en) | 2008-09-19 | 2016-05-17 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
WO2010100475A1 (en) * | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
US8664401B2 (en) | 2009-12-16 | 2014-03-04 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
US9180123B2 (en) | 2009-12-16 | 2015-11-10 | Pfizer Inc. | N-link hydroxamic acid derivatives useful as antibacterial agents |
WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
US9018384B2 (en) | 2009-12-16 | 2015-04-28 | Pfizer Inc. | N-link hydroxamic acid derivatives useful as antibacterial agents |
US8846933B2 (en) | 2009-12-16 | 2014-09-30 | Pfizer Inc. | N-link hydroxamic acid derivatives useful as antibacterial agents |
US10597361B2 (en) | 2010-09-03 | 2020-03-24 | Duke University | Ethynylbenzene derivatives |
US8779148B2 (en) | 2011-03-07 | 2014-07-15 | Pfizer Inc. | Fluoro-pyridinone derivatives useful as antibacterial agents |
US8624034B2 (en) | 2011-03-07 | 2014-01-07 | Pfizer Inc. | Fluoro-pyridinone derivatives useful as antibacterial agents |
US8809333B2 (en) | 2011-04-08 | 2014-08-19 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
US8748466B2 (en) | 2011-04-08 | 2014-06-10 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
US9403758B2 (en) | 2012-05-10 | 2016-08-02 | Achaogen, Inc. | Antibacterial agents |
US9701622B2 (en) | 2012-05-10 | 2017-07-11 | Achaogen, Inc. | Antibacterial agents |
WO2013170165A1 (en) * | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
CN107267159A (zh) * | 2012-11-21 | 2017-10-20 | 默克专利股份有限公司 | 可聚合化合物和其在液晶显示器中的用途 |
US20140139786A1 (en) * | 2012-11-21 | 2014-05-22 | Merck Patent Gmbh | Polymerisable compounds and the use thereof in liquid-crystal displays |
JP2016508487A (ja) * | 2013-01-28 | 2016-03-22 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 金属酵素阻害剤化合物 |
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US9663488B2 (en) | 2013-01-28 | 2017-05-30 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
AU2014209107B2 (en) * | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
US9908851B2 (en) | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
US10189786B2 (en) | 2013-08-16 | 2019-01-29 | Duke University | Antibacterial compounds |
US10647664B2 (en) | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
US20160185797A1 (en) * | 2013-08-22 | 2016-06-30 | Genentech, Inc. | Alkynyl alcohols and methods of use |
US20150057260A1 (en) * | 2013-08-22 | 2015-02-26 | Genentech, Inc. | Alkynyl alcohols and methods of use |
WO2016039433A1 (ja) * | 2014-09-12 | 2016-03-17 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体またはその塩を含有する医薬組成物 |
US10149911B2 (en) | 2014-09-12 | 2018-12-11 | Toyama Chemical Co., Ltd. | Pharmaceutical composition containing hydroxamic acid derivative or salt thereof |
WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
US10550117B2 (en) | 2016-08-24 | 2020-02-04 | Genentech, Inc. | 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use |
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CN111867600A (zh) * | 2018-03-15 | 2020-10-30 | 辉瑞大药厂 | 用作抗菌剂的吡啶酮和嘧啶酮磷酸盐和硼酸盐 |
CN109574980A (zh) * | 2018-11-28 | 2019-04-05 | 云南大学 | 基于罗丹明衍生物检测一氧化氮的荧光探针分子、制备及用途 |
EP4140994A1 (en) * | 2021-08-26 | 2023-03-01 | Idemitsu Kosan Co., Ltd. | Compound, material for an organic electroluminescence device and an organic electroluminescence device comprising the compound |
WO2023027196A1 (en) * | 2021-08-26 | 2023-03-02 | Idemitsu Kosan Co., Ltd. | Compound, material for an organic electroluminescence device and an organic electroluminescence device comprising the compound |
CN115448919A (zh) * | 2022-10-31 | 2022-12-09 | 滨州医学院附属医院 | 一种海洋来源的萘啶类抗炎活性化合物及其制备方法 |
CN115448919B (zh) * | 2022-10-31 | 2024-01-26 | 滨州医学院附属医院 | 一种海洋来源的萘啶类抗炎活性化合物及其制备方法 |
Also Published As
Publication number | Publication date |
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JPWO2008105515A1 (ja) | 2010-06-03 |
JP5227304B2 (ja) | 2013-07-03 |
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