EA201391325A1 - Новые производные цефалоспорина и их фармацевтические композиции - Google Patents

Новые производные цефалоспорина и их фармацевтические композиции

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Publication number
EA201391325A1
EA201391325A1 EA201391325A EA201391325A EA201391325A1 EA 201391325 A1 EA201391325 A1 EA 201391325A1 EA 201391325 A EA201391325 A EA 201391325A EA 201391325 A EA201391325 A EA 201391325A EA 201391325 A1 EA201391325 A1 EA 201391325A1
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EA
Eurasian Patent Office
Prior art keywords
new
pharmaceutical compositions
prodrug
solvate
isomer
Prior art date
Application number
EA201391325A
Other languages
English (en)
Other versions
EA024709B1 (ru
Inventor
Юн Лаг Чо
Джоун Йуль Йоун
Чуль Сун Парк
Сан Еунь Чае
Ньян Сук Ли
Кьюман Ох
Хье Джинь Хео
Дае Хьюк Кан
Юн Джае Ян
Хьюнь Джинь Квон
Тае Кью Парк
Сун Хо Ву
Йон Зу Ким
Original Assignee
Легокем Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Легокем Байосайенсиз, Инк. filed Critical Легокем Байосайенсиз, Инк.
Publication of EA201391325A1 publication Critical patent/EA201391325A1/ru
Publication of EA024709B1 publication Critical patent/EA024709B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретение относится к новым производным цефалоспорина, представленным химической формулой (1)где X, Y, L, Rи Rявляются такими, как определено в описании изобретения. Настоящее изобретение также относится к фармацевтическим антибиотическим композициям, содержащим новое производное цефалоспорина, представленное химической формулой (1), его пролекарство, его гидрат, его сольват, его изомер или его фармацевтически приемлемую соль в качестве эффективного ингредиента. Согласно настоящему изобретению предложены новые производные цефалоспорина, их пролекарство, их гидрат, их сольват, их изомер или их фармацевтически приемлемая соль в качестве ингредиента с низкой токсичностью, эффективного в отношении широкого спектра устойчивых к антибиотикам бактерий, в частности грамотрицательных, который может быть полезен сильной антимикробной активностью.
EA201391325A 2011-03-30 2012-03-29 Производные цефалоспорина и их фармацевтические композиции EA024709B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110028603A KR101719556B1 (ko) 2011-03-30 2011-03-30 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
PCT/KR2012/002302 WO2012134184A2 (ko) 2011-03-30 2012-03-29 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물

Publications (2)

Publication Number Publication Date
EA201391325A1 true EA201391325A1 (ru) 2014-04-30
EA024709B1 EA024709B1 (ru) 2016-10-31

Family

ID=46932135

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391325A EA024709B1 (ru) 2011-03-30 2012-03-29 Производные цефалоспорина и их фармацевтические композиции

Country Status (27)

Country Link
US (2) US8329684B2 (ru)
EP (1) EP2706062B1 (ru)
JP (1) JP6144669B2 (ru)
KR (1) KR101719556B1 (ru)
CN (1) CN103547583B (ru)
AU (1) AU2012237063B2 (ru)
BR (1) BR112013025275A2 (ru)
CA (1) CA2831421C (ru)
CL (1) CL2013002820A1 (ru)
CO (1) CO6821935A2 (ru)
CR (1) CR20130501A (ru)
CU (1) CU20130125A7 (ru)
DK (1) DK2706062T3 (ru)
DO (1) DOP2013000214A (ru)
EA (1) EA024709B1 (ru)
ES (1) ES2683351T3 (ru)
HR (1) HRP20181170T1 (ru)
HU (1) HUE039086T2 (ru)
IL (1) IL228408A (ru)
LT (1) LT2706062T (ru)
MX (1) MX359435B (ru)
PL (1) PL2706062T3 (ru)
PT (1) PT2706062T (ru)
SG (1) SG193998A1 (ru)
SI (1) SI2706062T1 (ru)
WO (1) WO2012134184A2 (ru)
ZA (1) ZA201308078B (ru)

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US8883772B2 (en) 2007-10-09 2014-11-11 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
US10059680B2 (en) * 2014-12-18 2018-08-28 Merck Sharp & Dohme Corp. Thiadiazolyl-oximinoacetic acid derivative compounds
US20160176897A1 (en) 2014-12-23 2016-06-23 Merck Sharp & Dohme Corp. 7-aminocephem derivative compounds
BR112018009725A8 (pt) 2015-12-10 2019-02-26 Naeja Rgm Pharmaceuticals Ulc compostos de cefém, sua produção e uso
CN109843896B (zh) * 2016-10-14 2022-12-20 波尔图大学 羟基肉桂酸衍生物、方法及其用途
KR20180093307A (ko) * 2017-02-13 2018-08-22 주식회사 레고켐 바이오사이언스 4, 5-디아미노 치환 피리미딘 유도체의 제조방법 및 이를 제조하기 위한 신규한 화합물
WO2019145784A2 (en) * 2018-01-26 2019-08-01 Legochem Biosciences, Inc. Combination therapies for multi-drug resistant pathogens
CN109762791B (zh) * 2018-11-19 2021-02-09 厦门联合安金生物工程有限公司 包含BPI-Fc嵌合基因的重组腺病毒及其用途
CN111471058A (zh) * 2019-01-23 2020-07-31 中国医学科学院药物研究所 用于制备头孢吡普类似物的方法
WO2021043973A1 (en) 2019-09-06 2021-03-11 Nabriva Therapeutics GmbH Siderophore cephalosporin conjugates and uses thereof
CN111635377A (zh) * 2020-06-30 2020-09-08 南京红杉生物科技有限公司 噻二唑类化合物及其合成方法
WO2022235077A1 (ko) * 2021-05-07 2022-11-10 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체

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DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
EP0303172A3 (de) * 1987-08-14 1991-05-15 F. Hoffmann-La Roche Ag Oxyimino-Cephalosporine
GB8817653D0 (en) * 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
GB9111406D0 (en) * 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US5498777A (en) * 1994-07-20 1996-03-12 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use
TW200305422A (en) * 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
DE602004012269T2 (de) * 2003-07-11 2009-04-30 Theravance, Inc., South San Francisco Quervernetzte glycopeptid-cephalosporin-antibiotika
AU2005219718A1 (en) * 2004-03-05 2005-09-15 Shionogi & Co., Ltd. 3-pyridinium methylcephem compound
AU2005202802A1 (en) * 2004-06-28 2006-01-12 Astellas Pharma Inc. Cephem compounds
CN101230070A (zh) * 2006-12-30 2008-07-30 黄振华 新型抗感染头孢类化合物
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Also Published As

Publication number Publication date
LT2706062T (lt) 2018-10-25
CN103547583A (zh) 2014-01-29
CN103547583B (zh) 2016-11-16
AU2012237063A1 (en) 2013-10-17
CU20130125A7 (es) 2014-03-26
JP6144669B2 (ja) 2017-06-07
EA024709B1 (ru) 2016-10-31
CA2831421A1 (en) 2012-10-04
BR112013025275A2 (pt) 2016-12-13
HRP20181170T1 (hr) 2018-11-02
WO2012134184A3 (ko) 2013-03-07
DOP2013000214A (es) 2013-12-15
MX2013010961A (es) 2014-03-27
US9630977B2 (en) 2017-04-25
ZA201308078B (en) 2019-01-30
JP2014510750A (ja) 2014-05-01
SI2706062T1 (sl) 2018-11-30
ES2683351T3 (es) 2018-09-26
EP2706062A4 (en) 2015-01-21
IL228408A (en) 2017-01-31
CL2013002820A1 (es) 2014-04-11
MX359435B (es) 2018-09-28
KR20120110625A (ko) 2012-10-10
SG193998A1 (en) 2013-11-29
US20120264727A1 (en) 2012-10-18
EP2706062B1 (en) 2018-05-09
CR20130501A (es) 2014-05-13
DK2706062T3 (en) 2018-08-06
IL228408A0 (en) 2013-12-31
PT2706062T (pt) 2018-09-28
HUE039086T2 (hu) 2018-12-28
EP2706062A2 (en) 2014-03-12
CA2831421C (en) 2019-06-04
KR101719556B1 (ko) 2017-03-24
US8329684B2 (en) 2012-12-11
AU2012237063B2 (en) 2017-03-16
WO2012134184A2 (ko) 2012-10-04
PL2706062T3 (pl) 2018-11-30
WO2012134184A8 (ko) 2013-10-24
US20130178455A1 (en) 2013-07-11
CO6821935A2 (es) 2013-12-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU