BR112013024497A2 - novo derivado de oxazolidinona e composição farmacêutica incluindo o mesmo - Google Patents

novo derivado de oxazolidinona e composição farmacêutica incluindo o mesmo

Info

Publication number
BR112013024497A2
BR112013024497A2 BR112013024497-6A BR112013024497A BR112013024497A2 BR 112013024497 A2 BR112013024497 A2 BR 112013024497A2 BR 112013024497 A BR112013024497 A BR 112013024497A BR 112013024497 A2 BR112013024497 A2 BR 112013024497A2
Authority
BR
Brazil
Prior art keywords
new oxazolidinone
formula
oxazolidinone derivative
new
prodrug
Prior art date
Application number
BR112013024497-6A
Other languages
English (en)
Korean (ko)
Inventor
Lag Cho Young
Yoon Baek Sung
Eun Chae Sang
Toung Kim Sun
Bum Lee Hong
Sook Lee Hyang
Oh Kyuman
Jin Heo Hye
Kyo Park Tae
Ho Woo Sung
Zu Kim Yong
Original Assignee
Legochem Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legochem Biosciences, Inc. filed Critical Legochem Biosciences, Inc.
Publication of BR112013024497A2 publication Critical patent/BR112013024497A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

novo derivado de oxazolidinona e composição farmacêutica incluindo o mesmo é revelado um novo derivado de oxazolidinona representado pela fórmula 1 acima, especificamente um novo composto oxazolidinona apresentando um grupo amidozima cíclica ou amidrazona cíclica. na fórmula 1, r e q são os mesmos conforme definidos na descrição detalhada. além disso, é revelada uma composição farmacêutica para um antibiótico que inclui o novo derivado de oxazolidinona da fórmula 1, pró-fármaco do mesmo, hidrato, solvato, isômero ou um sal farmaceuticamente aceitável como um ingrediente ativo. o novo derivado de oxazolidinona, pró-fármaco do mesmo, hidrato, solvato, isômero e sal farmaceuticamente aceitável do mesmo apresentam amplo espectro antibacteriano contra bactérias resistente, baixa toxicidade e efeitos antibacterianos fortes contra bactérias gram-positivas e gram-negativas e assim podem ser empregados eficazmente como antibióticos.
BR112013024497-6A 2011-03-30 2012-03-29 novo derivado de oxazolidinona e composição farmacêutica incluindo o mesmo BR112013024497A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020110028559A KR101653570B1 (ko) 2011-03-30 2011-03-30 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR10-2011-0028559 2011-03-30
PCT/KR2012/002314 WO2012134188A2 (ko) 2011-03-30 2012-03-29 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

Publications (1)

Publication Number Publication Date
BR112013024497A2 true BR112013024497A2 (pt) 2018-06-26

Family

ID=46932138

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013024497-6A BR112013024497A2 (pt) 2011-03-30 2012-03-29 novo derivado de oxazolidinona e composição farmacêutica incluindo o mesmo

Country Status (12)

Country Link
US (1) US8846669B2 (pt)
EP (2) EP3372598A1 (pt)
JP (1) JP6072764B2 (pt)
KR (1) KR101653570B1 (pt)
CN (1) CN103476772B (pt)
AU (1) AU2012237067B2 (pt)
BR (1) BR112013024497A2 (pt)
CA (1) CA2831799A1 (pt)
MX (1) MX337409B (pt)
RU (1) RU2617408C2 (pt)
WO (1) WO2012134188A2 (pt)
ZA (1) ZA201307216B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104774198A (zh) * 2014-01-15 2015-07-15 上海美迪西生物医药有限公司 一种新噁唑烷酮类化合物及其制备方法
CN106928214A (zh) * 2014-09-17 2017-07-07 博瑞生物医药（苏州）股份有限公司 一种噁唑烷酮类化合物及其中间体的制备方法
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
CN106045934A (zh) * 2015-10-27 2016-10-26 博瑞生物医药（苏州）股份有限公司 一种合成泰地唑胺的中间体的晶型
CN107722056A (zh) * 2017-10-31 2018-02-23 重庆华邦胜凯制药有限公司 磷酸特地唑胺的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
BR0111280A (pt) * 2000-06-05 2003-06-10 Dong A Pharm Co Ltd Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
JP2008500319A (ja) * 2004-05-25 2008-01-10 アストラゼネカ アクチボラグ 細菌感染症の治療のためのｍａｏ阻害剤としての３−（４−（２−ジヒドロイソオキサゾール−３−イルピリジン−５−イル）フェニル−５−トリアゾール−１−イルメチルオキサゾリジン−２−オン誘導体
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
KR100872059B1 (ko) * 2007-02-21 2008-12-05 주식회사 레고켐 바이오사이언스 아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR100870432B1 (ko) 2007-04-18 2008-11-25 주식회사 하이닉스반도체 트리밍 테스트모드 및 노말 테스트모드를 갖는반도체메모리소자
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR101037051B1 (ko) * 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법

Also Published As

Publication number Publication date
WO2012134188A3 (ko) 2013-01-10
EP3372598A1 (en) 2018-09-12
KR101653570B1 (ko) 2016-09-02
EP2692727A4 (en) 2014-10-15
AU2012237067A1 (en) 2013-10-03
CN103476772B (zh) 2016-03-30
AU2012237067B2 (en) 2016-07-28
ZA201307216B (en) 2014-12-23
US8846669B2 (en) 2014-09-30
EP2692727A2 (en) 2014-02-05
CN103476772A (zh) 2013-12-25
JP2014510751A (ja) 2014-05-01
US20140179691A1 (en) 2014-06-26
CA2831799A1 (en) 2012-10-04
WO2012134188A2 (ko) 2012-10-04
MX337409B (es) 2016-03-02
KR20120110600A (ko) 2012-10-10
MX2013011272A (es) 2014-03-21
RU2013143800A (ru) 2015-05-10
JP6072764B2 (ja) 2017-02-01
RU2617408C2 (ru) 2017-04-25

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