WO2012134188A3 - 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 - Google Patents

신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 Download PDF

Info

Publication number
WO2012134188A3
WO2012134188A3 PCT/KR2012/002314 KR2012002314W WO2012134188A3 WO 2012134188 A3 WO2012134188 A3 WO 2012134188A3 KR 2012002314 W KR2012002314 W KR 2012002314W WO 2012134188 A3 WO2012134188 A3 WO 2012134188A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel oxazolidinone
oxazolidinone derivative
chemical formula
present
composition containing
Prior art date
Application number
PCT/KR2012/002314
Other languages
English (en)
French (fr)
Other versions
WO2012134188A2 (ko
Inventor
조영락
백성윤
채상은
김선영
이홍범
이향숙
오규만
허혜진
박태교
우성호
김용주
Original Assignee
주식회사 레고켐 바이오사이언스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR112013024497-6A priority Critical patent/BR112013024497A2/ko
Application filed by 주식회사 레고켐 바이오사이언스 filed Critical 주식회사 레고켐 바이오사이언스
Priority to CA2831799A priority patent/CA2831799A1/en
Priority to CN201280016771.9A priority patent/CN103476772B/zh
Priority to RU2013143800A priority patent/RU2617408C2/ru
Priority to EP12764499.5A priority patent/EP2692727A4/en
Priority to AU2012237067A priority patent/AU2012237067B2/en
Priority to MX2013011272A priority patent/MX337409B/es
Priority to US14/008,702 priority patent/US8846669B2/en
Priority to EP18167465.6A priority patent/EP3372598A1/en
Priority to JP2014502469A priority patent/JP6072764B2/ja
Publication of WO2012134188A2 publication Critical patent/WO2012134188A2/ko
Publication of WO2012134188A3 publication Critical patent/WO2012134188A3/ko
Priority to ZA2013/07216A priority patent/ZA201307216B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

본 발명은 명세식 내에 화학식 1로 표시되는 신규한 옥사졸리디논 유도체, 특히 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 화합물에 관한 것이다. 상기 화학식1에서, R 및 Q는 발명의 상세한 설명에 정의된 바와 동일하다. 또한 본 발명은 상기 화학식 1의 신규한 옥사졸리디논 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염을 유효성분으로 함유하는 항생제용 의약 조성물에 관한 것이다. 본 발명에 따른 신규한 옥사졸리디논 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염은 내성균에 대한 항균 스펙트럼이 넓고, 독성이 낮으며, 그람양성 및 그람음성균에 강한 항균효과를 나타내므로, 항생제로 유용하게 사용될 수 있다.
PCT/KR2012/002314 2011-03-30 2012-03-29 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 WO2012134188A2 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU2012237067A AU2012237067B2 (en) 2011-03-30 2012-03-29 Novel oxazolidinone derivative and medical composition containing same
CA2831799A CA2831799A1 (en) 2011-03-30 2012-03-29 Oxazolidinone derivative and pharmaceutical composition including the same
CN201280016771.9A CN103476772B (zh) 2011-03-30 2012-03-29 噁唑烷酮衍生物及包含该噁唑烷酮衍生物的药物组合物
RU2013143800A RU2617408C2 (ru) 2011-03-30 2012-03-29 Новое производное оксазолидинона и включающая его фармацевтическая композиция
EP12764499.5A EP2692727A4 (en) 2011-03-30 2012-03-29 NEW OXAZOLIDINONE DERIVATIVE AND MEDICAL COMPOSITION THEREWITH
BR112013024497-6A BR112013024497A2 (ko) 2011-03-30 2012-03-29 Novel oxazolidinone derivatives and pharmaceutical compositions containing them
MX2013011272A MX337409B (es) 2011-03-30 2012-03-29 Derivado de oxazolidinona novedoso y composicion farmaceutica que incluye el mismo.
JP2014502469A JP6072764B2 (ja) 2011-03-30 2012-03-29 新規なオキサゾリジノン誘導体およびそれを含む医薬組成物
EP18167465.6A EP3372598A1 (en) 2011-03-30 2012-03-29 Novel oxazolidinone derivative and pharmaceutical composition including the same
US14/008,702 US8846669B2 (en) 2011-03-30 2012-03-29 Oxazolidinone derivative and medical composition containing same
ZA2013/07216A ZA201307216B (en) 2011-03-30 2013-09-26 Novel oxazolidinone derivative and pharmaceutical composition including the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110028559A KR101653570B1 (ko) 2011-03-30 2011-03-30 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR10-2011-0028559 2011-03-30

Publications (2)

Publication Number Publication Date
WO2012134188A2 WO2012134188A2 (ko) 2012-10-04
WO2012134188A3 true WO2012134188A3 (ko) 2013-01-10

Family

ID=46932138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/002314 WO2012134188A2 (ko) 2011-03-30 2012-03-29 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

Country Status (12)

Country Link
US (1) US8846669B2 (ko)
EP (2) EP3372598A1 (ko)
JP (1) JP6072764B2 (ko)
KR (1) KR101653570B1 (ko)
CN (1) CN103476772B (ko)
AU (1) AU2012237067B2 (ko)
BR (1) BR112013024497A2 (ko)
CA (1) CA2831799A1 (ko)
MX (1) MX337409B (ko)
RU (1) RU2617408C2 (ko)
WO (1) WO2012134188A2 (ko)
ZA (1) ZA201307216B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104774198A (zh) * 2014-01-15 2015-07-15 上海美迪西生物医药有限公司 一种新噁唑烷酮类化合物及其制备方法
CN106928214A (zh) * 2014-09-17 2017-07-07 博瑞生物医药（苏州）股份有限公司 一种噁唑烷酮类化合物及其中间体的制备方法
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
CN106045934A (zh) * 2015-10-27 2016-10-26 博瑞生物医药（苏州）股份有限公司 一种合成泰地唑胺的中间体的晶型
CN107722056A (zh) * 2017-10-31 2018-02-23 重庆华邦胜凯制药有限公司 磷酸特地唑胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080077828A (ko) * 2007-02-21 2008-08-26 주식회사 레고켐 바이오사이언스 아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
BR0111280A (pt) * 2000-06-05 2003-06-10 Dong A Pharm Co Ltd Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
JP2008500319A (ja) * 2004-05-25 2008-01-10 アストラゼネカ アクチボラグ 細菌感染症の治療のためのｍａｏ阻害剤としての３−（４−（２−ジヒドロイソオキサゾール−３−イルピリジン−５−イル）フェニル−５−トリアゾール−１−イルメチルオキサゾリジン−２−オン誘導体
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
KR100870432B1 (ko) 2007-04-18 2008-11-25 주식회사 하이닉스반도체 트리밍 테스트모드 및 노말 테스트모드를 갖는반도체메모리소자
KR101037051B1 (ko) * 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080077828A (ko) * 2007-02-21 2008-08-26 주식회사 레고켐 바이오사이언스 아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

Also Published As

Publication number Publication date
EP3372598A1 (en) 2018-09-12
KR101653570B1 (ko) 2016-09-02
EP2692727A4 (en) 2014-10-15
AU2012237067A1 (en) 2013-10-03
CN103476772B (zh) 2016-03-30
AU2012237067B2 (en) 2016-07-28
ZA201307216B (en) 2014-12-23
US8846669B2 (en) 2014-09-30
EP2692727A2 (en) 2014-02-05
CN103476772A (zh) 2013-12-25
JP2014510751A (ja) 2014-05-01
US20140179691A1 (en) 2014-06-26
BR112013024497A2 (ko) 2018-06-26
CA2831799A1 (en) 2012-10-04
WO2012134188A2 (ko) 2012-10-04
MX337409B (es) 2016-03-02
KR20120110600A (ko) 2012-10-10
MX2013011272A (es) 2014-03-21
RU2013143800A (ru) 2015-05-10
JP6072764B2 (ja) 2017-02-01
RU2617408C2 (ru) 2017-04-25

Similar Documents

Publication Publication Date Title
WO2012134184A3 (ko) 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
EP2662353A3 (en) Antibacterial agents
WO2010032147A3 (en) Hydroxamic acid derivatives useful as antibacterial agents
NZ593892A (en) Antibiotic compositions for the treatment of gram negative infections
WO2014209841A3 (en) Compounds for treating spinal muscular atrophy
EP3216798A3 (en) Ketolide compounds
GEP20156370B (en) Fluoro-pyridinone derivatives useful as antibacterial agents
EP2295402A3 (en) Antibacterial agents
WO2007069020A3 (en) N-hydroxyamide derivatives possessing antibacterial activity
WO2012134188A3 (ko) 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
WO2010047737A3 (en) Antimicrobial indoline compounds for treatment of bacterial infections
NZ594675A (en) Actagardine derivatives
MX2020000576A (es) Compuestos quimicos.
NZ596628A (en) Ketolide compounds having antimicrobial activity
WO2013106761A3 (en) Antimicrobial agents
NZ740051A (en) Tetracycline compounds
WO2014022382A3 (en) Antibacterial protein kinase inhibitors
EP4272831A3 (en) Diazabicyclooctanones as inhibitors of serine beta-lactamases
WO2010036000A3 (en) Novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone and pharmaceutical compositions thereof
WO2009116044A3 (en) Guanine nucleotide derivatives for treating bacterial infections
WO2008028805A3 (de) Verwendung einer pharmazeutischen zusammensetzung enthaltend ein anticholinergikum zur abtötung von mikroorganismen und zur behandlung von atemwegsinfektionen
MX2021003485A (es) Derivados de indano para uso en el tratamiento de infeccion bacteriana.
WO2012026988A3 (en) Dendrimeric peptides, pharmaceutical compositions and methods of using the same
WO2009077485A3 (en) 1(2)h-tetrazol-5-yl-phenyl-oxazolidinones as antibacterial agents
WO2010012381A8 (en) Streptospirole derivatives

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201280016771.9

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12764499

Country of ref document: EP

Kind code of ref document: A2

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2014502469

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2831799

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/A/2013/011272

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2012237067

Country of ref document: AU

Date of ref document: 20120329

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2013143800

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 14008702

Country of ref document: US

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112013024497

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112013024497

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20130924