BR0111280A - Novos derivados de oxazolidinona e um processo para a preparação dos mesmos - Google Patents

Novos derivados de oxazolidinona e um processo para a preparação dos mesmos

Info

Publication number
BR0111280A
BR0111280A BR0111280-5A BR0111280A BR0111280A BR 0111280 A BR0111280 A BR 0111280A BR 0111280 A BR0111280 A BR 0111280A BR 0111280 A BR0111280 A BR 0111280A
Authority
BR
Brazil
Prior art keywords
preparation
oxazolidinone derivatives
present
new
relates
Prior art date
Application number
BR0111280-5A
Other languages
English (en)
Inventor
Jae-Gul Lee
Won-Bin Leem
Jong-Hwan Cho
Sung-Hak Choi
Jong-Jin Lee
Sang-Kuk Park
Tae-Hoo Lee
Dong-Goo Kim
Hyun-Jung Sung
Original Assignee
Dong A Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000030896A external-priority patent/KR100674096B1/ko
Priority claimed from KR1020000056035A external-priority patent/KR100731469B1/ko
Priority claimed from KR1020010011691A external-priority patent/KR100713170B1/ko
Application filed by Dong A Pharm Co Ltd filed Critical Dong A Pharm Co Ltd
Publication of BR0111280A publication Critical patent/BR0111280A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"NOVOS DERIVADOS DE OXAZOLIDINONA E UM PROCESSO PARA A PREPARAçãO DOS MESMOS". A presente invenção se refere a novos derivados de oxazolidinona, seus sais farmaceuticamente aceitáveis, e a um processo para a preparação destes. Mais particularmente, a presente invenção se refere a derivados de oxazolidinona tendo quantidade de piridina e pirimidina substituída por heterociclo e heterocicloaromático na posição 4 do anel fenil. Os compostos da presente invenção têm amplo espectro antibacterial, atividade antibactericida superior, e baixa toxicidade, tal que o composto desta invenção pode ser usado como um agente antibacterial.
BR0111280-5A 2000-06-05 2001-05-18 Novos derivados de oxazolidinona e um processo para a preparação dos mesmos BR0111280A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20000030895 2000-06-05
KR1020000030896A KR100674096B1 (ko) 2000-06-05 2000-06-05 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법
KR1020000056035A KR100731469B1 (ko) 2000-06-05 2000-09-23 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
KR1020010011691A KR100713170B1 (ko) 2001-03-07 2001-03-07 헤테로고리 또는 헤테로아로마틱 고리가 치환된 피리딘고리를 포함하는 옥사졸리디논 유도체 및 그의 제조방법
PCT/KR2001/000821 WO2001094342A1 (en) 2000-06-05 2001-05-18 Novel oxazolidinone derivatives and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
BR0111280A true BR0111280A (pt) 2003-06-10

Family

ID=27483456

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111280-5A BR0111280A (pt) 2000-06-05 2001-05-18 Novos derivados de oxazolidinona e um processo para a preparação dos mesmos

Country Status (11)

Country Link
US (1) US6689779B2 (pt)
EP (1) EP1289984A4 (pt)
JP (1) JP2003535860A (pt)
CN (1) CN1433413A (pt)
AU (1) AU5889701A (pt)
BR (1) BR0111280A (pt)
CA (1) CA2411859A1 (pt)
HU (1) HUP0301562A2 (pt)
MX (1) MXPA02012045A (pt)
NZ (1) NZ522990A (pt)
WO (1) WO2001094342A1 (pt)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100674096B1 (ko) * 2000-06-05 2007-01-26 동아제약주식회사 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
CA2439208A1 (en) * 2001-02-27 2002-09-12 Kaneka Corporation Process for producing optically active n-aryl-1-amino-2-propanol derivatives
ATE304536T1 (de) * 2001-04-17 2005-09-15 Merck & Co Inc Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate
PL369183A1 (en) 2001-09-11 2005-04-18 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
US7094900B2 (en) 2002-08-12 2006-08-22 Pharmacia & Upjohn Company Llc N-Aryl-2-oxazolidinones and their derivatives
KR100856745B1 (ko) * 2002-10-18 2008-09-04 동아제약주식회사 헤테로 고리 및 헤테로아로마틱 고리가 치환 또는 융합된피리딘을 포함하는 옥사졸리디논 유도체 및 그의 제조방법
AU2003302404B2 (en) * 2002-11-28 2008-06-19 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
CA2507628A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinones as antibacterial agents
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
GB0229518D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
WO2005070904A2 (en) * 2003-06-03 2005-08-04 Rib-X Pharmaceutical, Inc. Sulfonamide compounds and methods of making and using the same
US8324398B2 (en) * 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
BRPI0411688A (pt) 2003-07-02 2006-12-26 Merck & Co Inc antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
UA88448C2 (ru) * 2003-07-02 2009-10-26 Мерк Энд Ко., Инк. Оксазолидиноновые антибиотики с замещенной циклопропильной группой и их производные
US20070197541A1 (en) * 2003-07-29 2007-08-23 Oyelere Adegboyega K Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
WO2005061468A1 (en) * 2003-12-17 2005-07-07 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1753755A1 (en) * 2004-05-25 2007-02-21 AstraZeneca AB 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
US20080021012A1 (en) * 2004-05-25 2008-01-24 Astrazeneca Ab 3-[4-{6-Substituted Alkanoyl Pyridin-3-Yl}-3-Phenyl]-5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones As Antibacterial Agents
WO2006022794A1 (en) * 2004-07-28 2006-03-02 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
WO2006018682A2 (en) * 2004-08-11 2006-02-23 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
US7592335B2 (en) 2005-04-15 2009-09-22 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
ATE496914T1 (de) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
CN100406455C (zh) * 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
AU2008247102B2 (en) * 2007-05-03 2011-11-24 Pfizer Limited 2 -pyridine carboxamide derivatives as sodium channel modulators
EP2072514A1 (en) * 2007-12-17 2009-06-24 Ferrer Internacional, S.A. 1(2)H-tetrazol-5-yl-phenyl-oxazolidinones as antibacterial agents
CN101560209B (zh) * 2008-04-15 2011-09-14 沈阳中海药业有限公司 含有嘧啶的噁唑烷酮类化合物及其制备方法
WO2009156484A2 (en) 2008-06-27 2009-12-30 Novartis Ag Organic compounds
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
MX366793B (es) * 2008-10-10 2019-07-24 Merck Sharp & Dohme Corp Star Metodos para preparar oxazolidinonas y composiciones que las contienen.
MX2011004372A (es) * 2008-10-27 2011-05-23 Mitsubishi Tanabe Pharma Corp Derivado de amida novedoso y uso del mismo como medicina.
AU2009318783A1 (en) 2008-11-20 2011-06-23 Panacea Biotec Ltd. Novel antimicrobials
SG173497A1 (en) 2009-02-03 2011-09-29 Trius Therapeutics Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
BR112012000657A2 (pt) 2009-06-26 2016-11-16 Panacea Biotec Ltd novos azabicilohexanos
CN101619061B (zh) * 2009-08-11 2014-12-17 沈阳药科大学 氰基吡啶基取代的噁唑烷酮类化合物
UA111145C2 (uk) 2009-10-13 2016-04-11 Мелінта Терап'Ютікс, Інк. Фармацевтична композиція
CN102260277B (zh) 2010-05-24 2013-07-24 中国科学院上海药物研究所 新型苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
US20120065170A1 (en) * 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
AU2011303597A1 (en) * 2010-09-17 2013-04-11 Purdue Pharma L.P. Pyridine compounds and the uses thereof
KR101944124B1 (ko) 2010-11-24 2019-01-30 멜린타 서브시디어리 코프. 약학 조성물
KR101653570B1 (ko) * 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2762479A4 (en) * 2011-09-29 2015-04-22 Xuanzhu Pharma Co Ltd OXAZOLIDINONE ANTIBACTERIAL MEDICINE BASED ON BIARYLIC HETEROCYCLE SUBSTITUTED
CN104364240B (zh) * 2012-06-08 2017-02-22 四川贝力克生物技术有限责任公司 一种用于预防或治疗分支杆菌疾病的药物
EP2970205B1 (en) 2013-03-14 2019-05-08 Tolero Pharmaceuticals, Inc. Jak2 and alk2 inhibitors and methods for their use
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
WO2014143659A1 (en) 2013-03-15 2014-09-18 Araxes Pharma Llc Irreversible covalent inhibitors of the gtpase k-ras g12c
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
US9573910B2 (en) 2013-11-08 2017-02-21 Lee Pharma Limited Oxazolidinone antibacterial compound
KR101561964B1 (ko) 2013-11-15 2015-10-20 한국과학기술연구원 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물
RU2713179C2 (ru) * 2014-02-21 2020-02-04 Фрост Биолоджик, Инк. Антимитотические амиды для лечения рака и пролиферативных заболеваний
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
EP3197870B1 (en) * 2014-09-25 2020-08-19 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
UY36402A (es) 2014-11-14 2016-06-30 Melinta Therapeutics Inc Método para tratar, prevenir, o reducir el riesgo de infección cutánea
AU2016245864C1 (en) 2015-04-10 2021-09-09 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
JP6789239B2 (ja) 2015-04-15 2020-11-25 アラクセス ファーマ エルエルシー Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356349A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356339A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356347A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356359B1 (en) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017070256A2 (en) 2015-10-19 2017-04-27 Araxes Pharma Llc Method for screening inhibitors of ras
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2017087528A1 (en) 2015-11-16 2017-05-26 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
WO2018068017A1 (en) 2016-10-07 2018-04-12 Araxes Pharma Llc Heterocyclic compounds as inhibitors of ras and methods of use thereof
EP3573967A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused hetero-hetero bicyclic compounds and methods of use thereof
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
EP3573964A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
KR20200010306A (ko) 2017-05-25 2020-01-30 아락세스 파마 엘엘씨 Kras의 공유적 억제제
US10736897B2 (en) 2017-05-25 2020-08-11 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
US11452719B2 (en) 2017-12-13 2022-09-27 Merck Sharp & Dohme Llc Pharmaceutical compositions of tedizolid phosphate
MX2020010437A (es) 2018-04-05 2021-01-29 Sumitomo Pharma Oncology Inc Inhibidores de axl cinasa y uso de los mismos.
JP2021530554A (ja) 2018-07-26 2021-11-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 異常なａｃｖｒ１発現を伴う疾患を処置するための方法およびそこで使用するためのａｃｖｒ１阻害剤
EP3914587A4 (en) * 2019-01-18 2022-11-23 Merck Sharp & Dohme LLC OXAZOLIDINONE COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS
IL299155A (en) * 2020-06-18 2023-02-01 Akagera Medicines Inc Oxazolidinone compounds, liposome preparations containing oxazolidinone compounds and methods of using them
CN113321683B (zh) * 2021-06-07 2022-08-26 南开大学 含有p–n键的化合物及制备方法
CN114213352B (zh) * 2021-12-09 2023-05-05 苏州汉德创宏生化科技有限公司 一种1-氧代-1-(2-氧代恶唑烷-3-基)丙-2-基4-甲基苯磺酸酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130316A (en) * 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
DE69216251T2 (de) 1991-11-01 1997-05-15 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte aryl- und heteroaryl-phenyloxazolidinone
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
KR100312903B1 (ko) * 1993-11-22 2002-02-28 로렌스 티. 마이젠헬더 치환된-하이드록시아세틸피페라진페닐옥사졸리디논의에스테르

Also Published As

Publication number Publication date
JP2003535860A (ja) 2003-12-02
HUP0301562A2 (hu) 2003-12-29
US6689779B2 (en) 2004-02-10
WO2001094342A1 (en) 2001-12-13
CA2411859A1 (en) 2001-12-13
US20030166620A1 (en) 2003-09-04
AU5889701A (en) 2001-12-17
NZ522990A (en) 2003-08-29
MXPA02012045A (es) 2003-10-15
CN1433413A (zh) 2003-07-30
EP1289984A4 (en) 2004-11-24
EP1289984A1 (en) 2003-03-12

Similar Documents

Publication Publication Date Title
BR0111280A (pt) Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
ES2191048T3 (es) Derivados de oxazolidinona y compuestos farmaceuticos que los contienen.
EA200100376A1 (ru) Арилсульфонанилидмочевины
BR0108893A (pt) Composição farmacêutica, composto e processo de preparação de compostos
BR0111263A (pt) Derivados de 2-aminocarbonil-9h-purina
BRPI9810519A (pt) derivados de 4''-substituído-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos.
ES2185635T3 (es) Derivados de benzamida y su uso como antagonistas de vasopresina.
BR0112224A (pt) Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
BR0213522B8 (pt) compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
PT1140993E (pt) Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
BRPI0112986B8 (pt) compostos azabicíclicos, processo para a sua preparação, bem como composições farmacêuticas compreendendo os ditos compostos
BR9908545A (pt) Derivado de piperidina, processo para a preparação do mesmo, composto, processo para a preparação do mesmo, e, composição farmacêutica
BR0317435A (pt) Derivados de pirimidina para o tratamento do crescimento celular anormal
AR005597A1 (es) Derivados de benzoxazina , composiciones farmaceuticas para el tratamiento de infecciones bacterianas, y metodo para la preparacion de dichos derivados.
BRPI0412502A (pt) derivados de ariltiouréia substituìda úteis como inibidores de replicação viral
BR0212069A (pt) Agentes antidiabéticos orais
BR9905089A (pt) Derivados macrolìdeos
BR0210548A (pt) éteres aromáticos substituìdos como inibidores do transporte de glicina e composição farmacêutica aque os compreende
DK1109560T3 (da) Som AICARFT-inhibitorer anvendelige forbindelser
YU25001A (sh) Optički aktivan derivat piridil-4h-1,2,4-oksadiazina i njegova upotreba u proizvodnji lekova za tretiranje vaskularnih bolesti
HUP0203226A2 (hu) Hatóanyagként benzamidszármazékot tartalmazó gyógyszerkészítmény
BR9805437A (pt) Derivados de benzocicloalquenos heterocìclicos, processo para fabricação de derivados de benzocicloalquenos heterocìclicos e uso de derivados de benzocicloalquenos heterocìclicos.
DK1411956T3 (da) Anvendelse af oversulfaterede polysaccharider som inhibitorer af HIV
YU32601A (sh) Derivati higromicina kao antibakterijski agensi
BR0212990A (pt) Sais farmacêuticamente aceitáveis de camptotecinas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.