MX2021014544A - Derivados de aminoglucosidos antibacterianos. - Google Patents

Derivados de aminoglucosidos antibacterianos.

Info

Publication number
MX2021014544A
MX2021014544A MX2021014544A MX2021014544A MX2021014544A MX 2021014544 A MX2021014544 A MX 2021014544A MX 2021014544 A MX2021014544 A MX 2021014544A MX 2021014544 A MX2021014544 A MX 2021014544A MX 2021014544 A MX2021014544 A MX 2021014544A
Authority
MX
Mexico
Prior art keywords
aminoglycoside derivatives
antibacterial aminoglycoside
antibacterial
derivatives
isomers
Prior art date
Application number
MX2021014544A
Other languages
English (en)
Inventor
Charles Z Ding
Shuhui Chen
Zhigang Huang
Cheng Li
Dongdong Tang
Original Assignee
Zhuohe Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhuohe Pharmaceutical Group Co Ltd filed Critical Zhuohe Pharmaceutical Group Co Ltd
Publication of MX2021014544A publication Critical patent/MX2021014544A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se describe una nueva clase de derivados de aminoglucósidos antibacterianos, composiciones farmacéuticas que contienen dichos compuestos, y su aplicación en la preparación de fármacos para el tratamiento de enfermedades relacionadas con infecciones bacterianas. Se describe específicamente un compuesto representado por la Fórmula (II), una sal farmacéuticamente aceptable de este e isómeros de este. (ver Fórmula).
MX2021014544A 2019-05-30 2020-05-29 Derivados de aminoglucosidos antibacterianos. MX2021014544A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910463155 2019-05-30
CN202010299506 2020-04-16
PCT/CN2020/093436 WO2020239096A1 (zh) 2019-05-30 2020-05-29 抗菌性氨基糖苷衍生物

Publications (1)

Publication Number Publication Date
MX2021014544A true MX2021014544A (es) 2022-01-06

Family

ID=73553506

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014544A MX2021014544A (es) 2019-05-30 2020-05-29 Derivados de aminoglucosidos antibacterianos.

Country Status (10)

Country Link
US (1) US20220227802A1 (es)
EP (1) EP3978506A4 (es)
JP (1) JP7249438B2 (es)
KR (1) KR20220007688A (es)
CN (1) CN114026105B (es)
AU (1) AU2020285280B2 (es)
CA (1) CA3142199C (es)
MX (1) MX2021014544A (es)
UA (1) UA127070C2 (es)
WO (1) WO2020239096A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116462721B (zh) * 2023-04-18 2024-02-02 江南大学 抗菌性氨基糖苷衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2706369C (en) 2007-11-21 2014-03-25 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132777A2 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of urinary tract infections with antibacterial aminoglycoside compounds
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010147836A1 (en) * 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
WO2017206947A1 (zh) * 2016-06-03 2017-12-07 南京明德新药研发股份有限公司 新型β-内酰胺酶抑制剂
CN107987111A (zh) * 2017-07-07 2018-05-04 朱孝云 抗菌性氘代氨基糖苷类衍生物
US20230285306A1 (en) 2018-09-28 2023-09-14 Axsome Therapeutics, Inc. Dosage forms comprising active pharmaceutical ingredients
WO2020117429A1 (en) 2018-12-04 2020-06-11 Purdue Research Foundation Novel antibacterial cell-penetrating peptides

Also Published As

Publication number Publication date
JP7249438B2 (ja) 2023-03-30
WO2020239096A1 (zh) 2020-12-03
AU2020285280B2 (en) 2022-11-10
EP3978506A4 (en) 2022-08-31
CN114026105B (zh) 2023-09-26
CA3142199A1 (en) 2020-12-03
US20220227802A1 (en) 2022-07-21
CA3142199C (en) 2023-09-05
AU2020285280A1 (en) 2021-12-23
JP2022534319A (ja) 2022-07-28
EP3978506A1 (en) 2022-04-06
CN114026105A (zh) 2022-02-08
KR20220007688A (ko) 2022-01-18
UA127070C2 (uk) 2023-03-29

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