CY1118915T1 - Αντιβακτηριακα αναλογα αμινογλυκοσιδης - Google Patents
Αντιβακτηριακα αναλογα αμινογλυκοσιδηςInfo
- Publication number
- CY1118915T1 CY1118915T1 CY20171100134T CY171100134T CY1118915T1 CY 1118915 T1 CY1118915 T1 CY 1118915T1 CY 20171100134 T CY20171100134 T CY 20171100134T CY 171100134 T CY171100134 T CY 171100134T CY 1118915 T1 CY1118915 T1 CY 1118915T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- antibacterial aminoglycoside
- aminoglycoside analogs
- disclosed
- analogs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Αποκαλύπτονται ενώσεις του συντακτικού τύπου (I): οι οποίες έχουν αντιβακτηριακή δραστικότητα, όπου περιλαμβάνονται στερεοϊσομερή, φαρμακευτικά αποδεκτά άλατα και προφάρμακα αυτών, όπου τα Q1, Q2, Q3, R8 και R9 είναι όπως ορίζεται εις το παρόν κείμενο. Αποκαλύπτονται επίσης μέθοδοι οι οποίες αφορούν την παρασκευή και τη χρήση τέτοιων ενώσεων, όπως επίσης φαρμακευτικών συνθέσεων οι οποίες περιέχουν τέτοιες ενώσεις.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98964507P | 2007-11-21 | 2007-11-21 | |
PCT/US2008/084399 WO2009067692A1 (en) | 2007-11-21 | 2008-11-21 | Antibacterial aminoglycoside analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118915T1 true CY1118915T1 (el) | 2018-01-10 |
Family
ID=40512286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100134T CY1118915T1 (el) | 2007-11-21 | 2017-01-31 | Αντιβακτηριακα αναλογα αμινογλυκοσιδης |
Country Status (22)
Country | Link |
---|---|
US (5) | US8383596B2 (el) |
EP (2) | EP2217610B1 (el) |
JP (2) | JP4986310B2 (el) |
KR (1) | KR101296099B1 (el) |
CN (2) | CN103360440B (el) |
AU (1) | AU2008326297B2 (el) |
BR (1) | BRPI0819319B8 (el) |
CA (1) | CA2706369C (el) |
CY (1) | CY1118915T1 (el) |
DK (1) | DK2217610T3 (el) |
EA (1) | EA017824B1 (el) |
ES (1) | ES2613936T3 (el) |
HR (1) | HRP20170154T1 (el) |
HU (1) | HUE030523T2 (el) |
IL (1) | IL205880A (el) |
LT (1) | LT2217610T (el) |
MX (1) | MX2010005632A (el) |
PL (1) | PL2217610T3 (el) |
PT (1) | PT2217610T (el) |
SI (1) | SI2217610T1 (el) |
TW (1) | TWI425947B (el) |
WO (1) | WO2009067692A1 (el) |
Families Citing this family (32)
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ES2707787T3 (es) | 2005-12-02 | 2019-04-05 | Ionis Pharmaceuticals Inc | Análogos antibacterianos de aminoglucósido 4,5-sustituidos que tienen sustituyentes múltiples |
EP2148884A1 (en) * | 2007-04-10 | 2010-02-03 | Achaogen, Inc. | Antibacterial 1,4,5-substituted aminoglycoside analogs |
WO2009067692A1 (en) | 2007-11-21 | 2009-05-28 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010030704A2 (en) | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010030690A1 (en) | 2008-09-10 | 2010-03-18 | Isis Pharmaceuticals, Inc. | Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs |
WO2010042850A1 (en) | 2008-10-09 | 2010-04-15 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010042851A1 (en) | 2008-10-09 | 2010-04-15 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
CA2761756A1 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Treatment of urinary tract infections with antibacterial aminoglycoside compounds |
TW201100091A (en) * | 2009-05-14 | 2011-01-01 | Achaogen Inc | Aminoglycoside dosing regimens |
CA2948868A1 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Treatment of klebsiella pneumoniae infections with antibacterial aminoglycoside compounds |
WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010132768A1 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
WO2010132757A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
WO2010147836A1 (en) * | 2009-06-17 | 2010-12-23 | Achaogen, Inc. | Combination therapies using antibacterial aminoglycoside compounds |
CN102596981A (zh) | 2009-10-09 | 2012-07-18 | 尔察祯有限公司 | 抗菌氨基糖苷类类似物 |
CN103282370A (zh) * | 2010-11-17 | 2013-09-04 | 尔察祯有限公司 | 抗菌氨基糖苷类类似物 |
US9238670B2 (en) | 2013-03-15 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Aminoglycoside antibiotics with reduced ototoxicity |
KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
MX2018001022A (es) | 2015-07-30 | 2018-05-17 | Microbial Chem Res Found | Antibiotico aminoglucosido novedoso efectivo contra bacterias resistentes a multiples farmacos. |
CN107987111A (zh) * | 2017-07-07 | 2018-05-04 | 朱孝云 | 抗菌性氘代氨基糖苷类衍生物 |
MX2020003701A (es) | 2017-10-19 | 2020-07-22 | Cipla Usa Inc | Sintesis de analogos de aminoglucosidos antibacterianos. |
CN109900816A (zh) * | 2017-12-11 | 2019-06-18 | 江苏省食品药品监督检验研究院 | 一种分析注射用硫酸核糖霉素含量及有关物质的高效液相色谱蒸发光散射检测器法 |
CN108948107B (zh) * | 2018-07-30 | 2020-05-05 | 山东大学 | 一种普拉佐米星抗生素的制备方法 |
WO2020115190A1 (en) | 2018-12-05 | 2020-06-11 | Agilebiotics B.V. | Novel antibacterial 3"-derivatives of 4,6-disubstituted 2,5-dideoxystreptamine aminoglycoside antibiotics |
UA127070C2 (uk) * | 2019-05-30 | 2023-03-29 | Чжуохе Фармасьютікал Груп Ко., Лтд | Антибактеріальні похідні аміноглікозидів |
CN110878108B (zh) * | 2019-06-17 | 2022-11-11 | 山东安信制药有限公司 | 一种普拉佐米星的合成方法 |
CN110885350A (zh) * | 2019-08-28 | 2020-03-17 | 山东安信制药有限公司 | 一种普拉佐米星的制备方法 |
CN110642907B (zh) * | 2019-10-12 | 2020-11-06 | 上海博璞诺科技发展有限公司 | 普拉唑米星或其盐的合成方法 |
CN111004292A (zh) * | 2019-12-19 | 2020-04-14 | 卓和药业集团有限公司 | 庆大霉素衍生物及其制备方法 |
CN116462721B (zh) * | 2023-04-18 | 2024-02-02 | 江南大学 | 抗菌性氨基糖苷衍生物 |
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