CY1118915T1 - Αντιβακτηριακα αναλογα αμινογλυκοσιδης - Google Patents

Αντιβακτηριακα αναλογα αμινογλυκοσιδης

Info

Publication number
CY1118915T1
CY1118915T1 CY20171100134T CY171100134T CY1118915T1 CY 1118915 T1 CY1118915 T1 CY 1118915T1 CY 20171100134 T CY20171100134 T CY 20171100134T CY 171100134 T CY171100134 T CY 171100134T CY 1118915 T1 CY1118915 T1 CY 1118915T1
Authority
CY
Cyprus
Prior art keywords
compounds
antibacterial aminoglycoside
aminoglycoside analogs
disclosed
analogs
Prior art date
Application number
CY20171100134T
Other languages
English (en)
Inventor
James Aggen
Adam Aaron Goldblum
Martin Linsell
Paola DOΖΖO
Heinz Ernst Moser
Darin Hildebrandt
Micah Gliedt
Original Assignee
Achaogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen, Inc. filed Critical Achaogen, Inc.
Publication of CY1118915T1 publication Critical patent/CY1118915T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Αποκαλύπτονται ενώσεις του συντακτικού τύπου (I): οι οποίες έχουν αντιβακτηριακή δραστικότητα, όπου περιλαμβάνονται στερεοϊσομερή, φαρμακευτικά αποδεκτά άλατα και προφάρμακα αυτών, όπου τα Q1, Q2, Q3, R8 και R9 είναι όπως ορίζεται εις το παρόν κείμενο. Αποκαλύπτονται επίσης μέθοδοι οι οποίες αφορούν την παρασκευή και τη χρήση τέτοιων ενώσεων, όπως επίσης φαρμακευτικών συνθέσεων οι οποίες περιέχουν τέτοιες ενώσεις.
CY20171100134T 2007-11-21 2017-01-31 Αντιβακτηριακα αναλογα αμινογλυκοσιδης CY1118915T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98964507P 2007-11-21 2007-11-21
PCT/US2008/084399 WO2009067692A1 (en) 2007-11-21 2008-11-21 Antibacterial aminoglycoside analogs

Publications (1)

Publication Number Publication Date
CY1118915T1 true CY1118915T1 (el) 2018-01-10

Family

ID=40512286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100134T CY1118915T1 (el) 2007-11-21 2017-01-31 Αντιβακτηριακα αναλογα αμινογλυκοσιδης

Country Status (22)

Country Link
US (5) US8383596B2 (el)
EP (2) EP3150617B1 (el)
JP (2) JP4986310B2 (el)
KR (1) KR101296099B1 (el)
CN (2) CN103360440B (el)
AU (1) AU2008326297B2 (el)
BR (1) BRPI0819319B8 (el)
CA (1) CA2706369C (el)
CY (1) CY1118915T1 (el)
DK (1) DK2217610T3 (el)
EA (1) EA017824B1 (el)
ES (1) ES2613936T3 (el)
HR (1) HRP20170154T1 (el)
HU (1) HUE030523T2 (el)
IL (1) IL205880A (el)
LT (1) LT2217610T (el)
MX (1) MX2010005632A (el)
PL (1) PL2217610T3 (el)
PT (1) PT2217610T (el)
SI (1) SI2217610T1 (el)
TW (1) TWI425947B (el)
WO (1) WO2009067692A1 (el)

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ES2707787T3 (es) 2005-12-02 2019-04-05 Ionis Pharmaceuticals Inc Análogos antibacterianos de aminoglucósido 4,5-sustituidos que tienen sustituyentes múltiples
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AU2008326297B2 (en) 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
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CN107987111A (zh) * 2017-07-07 2018-05-04 朱孝云 抗菌性氘代氨基糖苷类衍生物
JP7235741B2 (ja) 2017-10-19 2023-03-08 シプラ ユーエスエイ， インコーポレイテッド 抗菌性アミノグリコシド類似体の合成
CN109900816A (zh) * 2017-12-11 2019-06-18 江苏省食品药品监督检验研究院 一种分析注射用硫酸核糖霉素含量及有关物质的高效液相色谱蒸发光散射检测器法
CN108948107B (zh) * 2018-07-30 2020-05-05 山东大学 一种普拉佐米星抗生素的制备方法
EP3891162B1 (en) 2018-12-05 2024-03-06 AGILeBiotics B.V. Novel derivatives of n-3"-guanidino-2,5-dideoxy-5-fluoro-4,6-disubstituted-streptamine aminoglycoside antibiotics
UA127070C2 (uk) * 2019-05-30 2023-03-29 Чжуохе Фармасьютікал Груп Ко., Лтд Антибактеріальні похідні аміноглікозидів
CN110878108B (zh) * 2019-06-17 2022-11-11 山东安信制药有限公司 一种普拉佐米星的合成方法
CN110885350A (zh) * 2019-08-28 2020-03-17 山东安信制药有限公司 一种普拉佐米星的制备方法
CN110642907B (zh) * 2019-10-12 2020-11-06 上海博璞诺科技发展有限公司 普拉唑米星或其盐的合成方法
CN111004292A (zh) * 2019-12-19 2020-04-14 卓和药业集团有限公司 庆大霉素衍生物及其制备方法
CN116462721B (zh) * 2023-04-18 2024-02-02 江南大学 抗菌性氨基糖苷衍生物

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