BR112019006129A2 - derivados de tetra-hidropiridina e seu uso como agentes antibacterianos - Google Patents
derivados de tetra-hidropiridina e seu uso como agentes antibacterianosInfo
- Publication number
- BR112019006129A2 BR112019006129A2 BR112019006129A BR112019006129A BR112019006129A2 BR 112019006129 A2 BR112019006129 A2 BR 112019006129A2 BR 112019006129 A BR112019006129 A BR 112019006129A BR 112019006129 A BR112019006129 A BR 112019006129A BR 112019006129 A2 BR112019006129 A2 BR 112019006129A2
- Authority
- BR
- Brazil
- Prior art keywords
- bacterial infections
- compounds
- methods
- negative bacterial
- gram
- Prior art date
Links
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 tetrahydropyridine derivative compound Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
a presente revelação se refere a um composto de derivado de tetra-hidropiridina inovador, um estereoisômero do mesmo ou um sal farmaceuticamente aceitável do mesmo, métodos para preparar os compostos, métodos para inibir udp-3-o-(r-3-hidroximiristoil)-n-acetilglicosamina desacetilase (lpxc), métodos para tratar infecções bacterianas gram-negativas, uso dos compostos para a preparação de medicamentos terapêuticos para tratar infecções bacterianas gram-negativas, e composições farmacêuticas para prevenção ou tratamento de infecções bacterianas gram-negativas, que contêm os compostos. os compostos representados pela fórmula i, estereoisômeros do mesmo ou sais farmaceuticamente aceitáveis do mesmo de acordo com o presente revelação podem exibir efeitos excelentes no tratamento de infecções bacterianas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662400694P | 2016-09-28 | 2016-09-28 | |
| PCT/KR2017/010896 WO2018062924A1 (en) | 2016-09-28 | 2017-09-28 | Tetrahydropyridine derivatives and their use as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019006129A2 true BR112019006129A2 (pt) | 2019-06-18 |
Family
ID=61687790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019006129A BR112019006129A2 (pt) | 2016-09-28 | 2017-09-28 | derivados de tetra-hidropiridina e seu uso como agentes antibacterianos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10160724B2 (pt) |
| EP (1) | EP3519387B1 (pt) |
| JP (1) | JP6812542B2 (pt) |
| KR (1) | KR102264248B1 (pt) |
| CN (1) | CN110088087B (pt) |
| AU (1) | AU2017337946B2 (pt) |
| BR (1) | BR112019006129A2 (pt) |
| CA (1) | CA3037118C (pt) |
| ES (1) | ES2891025T3 (pt) |
| MX (1) | MX2019003585A (pt) |
| PL (1) | PL3519387T3 (pt) |
| PT (1) | PT3519387T (pt) |
| RU (1) | RU2722594C1 (pt) |
| WO (1) | WO2018062924A1 (pt) |
| ZA (1) | ZA201901945B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0311201D0 (en) * | 2003-05-15 | 2003-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| US7879911B2 (en) * | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| CA2774250C (en) * | 2009-10-13 | 2013-12-17 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| EP2694481B1 (en) * | 2011-04-08 | 2015-12-30 | Pfizer Inc | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| SG193367A1 (en) * | 2011-04-08 | 2013-10-30 | Pfizer | Isoxazole derivatives useful as antibacterial agents |
| WO2013170165A1 (en) * | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| EP3134401B1 (en) * | 2014-04-22 | 2018-06-13 | Novartis AG | Isoxazoline hydroxamic acid derivatives as lpxc inhibitors |
| EP3143007B1 (en) | 2014-05-16 | 2018-07-11 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| RU2018124788A (ru) * | 2015-12-08 | 2020-01-15 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Замещенные бензазиноны в качестве антибактериальных соединений |
-
2017
- 2017-09-28 EP EP17856810.1A patent/EP3519387B1/en active Active
- 2017-09-28 KR KR1020197012063A patent/KR102264248B1/ko active IP Right Grant
- 2017-09-28 JP JP2019516938A patent/JP6812542B2/ja active Active
- 2017-09-28 CN CN201780059711.8A patent/CN110088087B/zh active Active
- 2017-09-28 PT PT178568101T patent/PT3519387T/pt unknown
- 2017-09-28 US US15/718,474 patent/US10160724B2/en active Active
- 2017-09-28 RU RU2019112881A patent/RU2722594C1/ru active
- 2017-09-28 BR BR112019006129A patent/BR112019006129A2/pt active Search and Examination
- 2017-09-28 CA CA3037118A patent/CA3037118C/en active Active
- 2017-09-28 ES ES17856810T patent/ES2891025T3/es active Active
- 2017-09-28 MX MX2019003585A patent/MX2019003585A/es unknown
- 2017-09-28 AU AU2017337946A patent/AU2017337946B2/en active Active
- 2017-09-28 PL PL17856810T patent/PL3519387T3/pl unknown
- 2017-09-28 WO PCT/KR2017/010896 patent/WO2018062924A1/en unknown
-
2019
- 2019-03-28 ZA ZA2019/01945A patent/ZA201901945B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2891025T3 (es) | 2022-01-25 |
| AU2017337946B2 (en) | 2020-05-07 |
| PT3519387T (pt) | 2021-09-28 |
| WO2018062924A1 (en) | 2018-04-05 |
| PL3519387T3 (pl) | 2022-02-07 |
| EP3519387A1 (en) | 2019-08-07 |
| JP2019534252A (ja) | 2019-11-28 |
| KR102264248B1 (ko) | 2021-06-14 |
| ZA201901945B (en) | 2022-07-27 |
| EP3519387B1 (en) | 2021-08-11 |
| EP3519387A4 (en) | 2020-05-13 |
| MX2019003585A (es) | 2019-06-10 |
| NZ751511A (en) | 2020-11-27 |
| RU2722594C1 (ru) | 2020-06-02 |
| CN110088087B (zh) | 2022-08-09 |
| US10160724B2 (en) | 2018-12-25 |
| US20180086709A1 (en) | 2018-03-29 |
| CN110088087A (zh) | 2019-08-02 |
| KR20190047127A (ko) | 2019-05-07 |
| CA3037118A1 (en) | 2018-04-05 |
| JP6812542B2 (ja) | 2021-01-13 |
| CA3037118C (en) | 2021-12-14 |
| AU2017337946A1 (en) | 2019-04-04 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |