DK282285A - Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser - Google Patents
Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser Download PDFInfo
- Publication number
- DK282285A DK282285A DK282285A DK282285A DK282285A DK 282285 A DK282285 A DK 282285A DK 282285 A DK282285 A DK 282285A DK 282285 A DK282285 A DK 282285A DK 282285 A DK282285 A DK 282285A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- compounds
- acid addition
- addition salts
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843423092 DE3423092A1 (de) | 1984-06-22 | 1984-06-22 | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
DK282285D0 DK282285D0 (da) | 1985-06-21 |
DK282285A true DK282285A (da) | 1985-12-23 |
Family
ID=6238919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK282285A DK282285A (da) | 1984-06-22 | 1985-06-21 | Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser |
Country Status (19)
Country | Link |
---|---|
US (1) | US4714698A (da) |
EP (1) | EP0167817B1 (da) |
JP (1) | JPH0694465B2 (da) |
KR (1) | KR920007435B1 (da) |
AT (1) | ATE46511T1 (da) |
AU (1) | AU579869B2 (da) |
CA (1) | CA1241325A (da) |
DE (2) | DE3423092A1 (da) |
DK (1) | DK282285A (da) |
ES (1) | ES8604590A1 (da) |
FI (1) | FI80455C (da) |
GR (1) | GR851467B (da) |
IE (1) | IE58432B1 (da) |
IL (1) | IL75596A0 (da) |
NO (1) | NO161620C (da) |
NZ (1) | NZ212515A (da) |
PH (1) | PH21319A (da) |
PT (1) | PT80670B (da) |
ZA (1) | ZA854683B (da) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH075594B2 (ja) * | 1986-03-25 | 1995-01-25 | 三井石油化学工業株式会社 | 新規ピリドピリミジン誘導体 |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
US4885300A (en) * | 1988-03-03 | 1989-12-05 | Ortho Pharmaceutical Corporation | 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives |
DE4325900A1 (de) * | 1993-08-02 | 1995-02-09 | Thomae Gmbh Dr K | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
ATE549338T1 (de) * | 2006-05-24 | 2012-03-15 | Boehringer Ingelheim Int | Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1116676B (de) * | 1955-03-14 | 1961-11-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von Pyrimido [5, 4-d] pyrimidinen |
US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
US3322755A (en) * | 1964-03-10 | 1967-05-30 | Boehringer Sohn Ingelheim | Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines |
GB1190419A (en) * | 1966-08-16 | 1970-05-06 | Yamanouchi Pharma Co Ltd | Substituted Pyrimido-Pyrimidines and a process for the preparation thereof |
DE2926804A1 (de) * | 1979-07-03 | 1981-01-22 | Thomae Gmbh Dr K | Neue 2-(perhydro-1,4-diazino)-pyrimido- eckige klammer auf 5,4-d eckige klammer zu pyrimidine, deren herstellung und verwendung als arzneimittel |
EP0023559B1 (de) * | 1979-07-03 | 1984-09-19 | Dr. Karl Thomae GmbH | 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel |
DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
-
1984
- 1984-06-22 DE DE19843423092 patent/DE3423092A1/de not_active Withdrawn
-
1985
- 1985-06-04 DE DE8585106900T patent/DE3573119D1/de not_active Expired
- 1985-06-04 AT AT85106900T patent/ATE46511T1/de not_active IP Right Cessation
- 1985-06-04 EP EP85106900A patent/EP0167817B1/de not_active Expired
- 1985-06-17 GR GR851467A patent/GR851467B/el unknown
- 1985-06-17 US US06/745,095 patent/US4714698A/en not_active Expired - Fee Related
- 1985-06-20 PT PT80670A patent/PT80670B/pt not_active IP Right Cessation
- 1985-06-20 FI FI852445A patent/FI80455C/fi not_active IP Right Cessation
- 1985-06-21 NZ NZ212515A patent/NZ212515A/xx unknown
- 1985-06-21 KR KR1019850004411A patent/KR920007435B1/ko not_active IP Right Cessation
- 1985-06-21 AU AU43968/85A patent/AU579869B2/en not_active Ceased
- 1985-06-21 CA CA000484743A patent/CA1241325A/en not_active Expired
- 1985-06-21 JP JP60135820A patent/JPH0694465B2/ja not_active Expired - Lifetime
- 1985-06-21 NO NO852514A patent/NO161620C/no unknown
- 1985-06-21 DK DK282285A patent/DK282285A/da not_active Application Discontinuation
- 1985-06-21 PH PH32439A patent/PH21319A/en unknown
- 1985-06-21 IL IL75596A patent/IL75596A0/xx not_active IP Right Cessation
- 1985-06-21 ZA ZA854683A patent/ZA854683B/xx unknown
- 1985-06-21 IE IE154585A patent/IE58432B1/en not_active IP Right Cessation
- 1985-06-21 ES ES544417A patent/ES8604590A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI852445L (fi) | 1985-12-23 |
JPS6115883A (ja) | 1986-01-23 |
DK282285D0 (da) | 1985-06-21 |
DE3423092A1 (de) | 1986-01-02 |
AU579869B2 (en) | 1988-12-15 |
IE851545L (en) | 1985-12-22 |
CA1241325A (en) | 1988-08-30 |
FI80455C (fi) | 1990-06-11 |
GR851467B (da) | 1985-11-25 |
IE58432B1 (en) | 1993-09-22 |
IL75596A0 (en) | 1985-10-31 |
FI80455B (fi) | 1990-02-28 |
NO161620B (no) | 1989-05-29 |
EP0167817A1 (de) | 1986-01-15 |
US4714698A (en) | 1987-12-22 |
PT80670A (de) | 1985-07-01 |
JPH0694465B2 (ja) | 1994-11-24 |
ZA854683B (en) | 1987-02-25 |
PT80670B (de) | 1987-05-08 |
EP0167817B1 (de) | 1989-09-20 |
KR920007435B1 (ko) | 1992-09-01 |
FI852445A0 (fi) | 1985-06-20 |
NZ212515A (en) | 1988-10-28 |
KR860000287A (ko) | 1986-01-27 |
AU4396885A (en) | 1986-01-02 |
DE3573119D1 (en) | 1989-10-26 |
ES544417A0 (es) | 1986-02-01 |
ATE46511T1 (de) | 1989-10-15 |
PH21319A (en) | 1987-09-28 |
NO852514L (no) | 1985-12-23 |
ES8604590A1 (es) | 1986-02-01 |
NO161620C (no) | 1989-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment |