KR860001808A - 이미다조〔1,5-a〕피리미딘 유도체의 제조방법 - Google Patents
이미다조〔1,5-a〕피리미딘 유도체의 제조방법 Download PDFInfo
- Publication number
- KR860001808A KR860001808A KR1019850005653A KR850005653A KR860001808A KR 860001808 A KR860001808 A KR 860001808A KR 1019850005653 A KR1019850005653 A KR 1019850005653A KR 850005653 A KR850005653 A KR 850005653A KR 860001808 A KR860001808 A KR 860001808A
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- KR
- South Korea
- Prior art keywords
- group
- substituted
- imidazo
- preparing
- atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 축합제(예:염화포스포릴, 염화티오닐)를 사용하여 일반식(Ⅱ)의 N-아실아미노메틸 피리미딘 화합물을 전환시킴을 특징으로 하는, 일반식(Ⅲ)의 이미다조[1,5-a] 피리미딘 화합물의 제조방법.상기 식에서, R1은 할로겐원자이고; X는 황원자, 설피닐그룹, 설포닐그룹 또는 산소원자이고; m 및 n은 각각 독립적으로 0 또는 1이고; A는 치환될 수 있는 페닐그룹, 사이클로알킬그룹 또는 치환될 수 있는 방향족 헤테로사이클 그룹이나; 단, m이 0인 경우에는 A는 치환될 수 있는 페닐그룹 또는 사이크로알킬그룹아니다.
- 할로겐화제(예:N-할로석신이미드)를 사용하여 일반식(Ⅲ)의 화합물을 전환시킴을 특징으로하는 일반식(Ⅳ)의 이미다조[1,5-a] 피리미딘 유도체의 제조방법.상기 식에서, R1은 할로겐원자이고, X는 황원자, 설피닐그룹, 설포닐그룹 또는 산소원자이고; m 및 n은 각각 독립적으로 0 또는 1이고; A는 치환될 수 있는 페닐그룹, 사이클로알킬그룹 또는 치환될 수 있는 방향족 헤테로사이클 그룹이고; R은 할로겐원자이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59165468A JPS6143191A (ja) | 1984-08-07 | 1984-08-07 | イミダゾ〔1,5−a〕ピリミジン誘導体 |
JP165468/84 | 1984-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR860001808A true KR860001808A (ko) | 1986-03-22 |
Family
ID=15812984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850005653A KR860001808A (ko) | 1984-08-07 | 1985-08-06 | 이미다조〔1,5-a〕피리미딘 유도체의 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US4914104A (ko) |
EP (1) | EP0171739B1 (ko) |
JP (1) | JPS6143191A (ko) |
KR (1) | KR860001808A (ko) |
AT (1) | ATE49411T1 (ko) |
AU (1) | AU582377B2 (ko) |
CA (1) | CA1244019A (ko) |
DE (1) | DE3575305D1 (ko) |
DK (1) | DK357285A (ko) |
ES (2) | ES8609327A1 (ko) |
HU (1) | HU192344B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823042D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
GB8823041D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
IE914327A1 (en) * | 1990-12-13 | 1992-06-17 | Smithkline Beecham Corp | Novel csaids |
US6297198B1 (en) | 1996-05-14 | 2001-10-02 | Syngenta Participations Ag | Isoxazole derivatives and their use as herbicides |
BR0309892A2 (pt) * | 2002-05-09 | 2011-04-05 | Cytokinetics Inc | composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto |
JP2005530806A (ja) * | 2002-05-23 | 2005-10-13 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害薬 |
US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
CA2484761C (en) | 2002-05-24 | 2010-11-09 | Angiotech International Ag | Compositions and methods for coating medical implants |
JP2007518711A (ja) * | 2003-12-19 | 2007-07-12 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
WO2006088028A1 (ja) * | 2005-02-15 | 2006-08-24 | Gifu University | 2-アザインドリジン類の製造方法、2-アザインドリジン類金属錯体の製造方法及び2-アザインドリジン類金属錯体 |
KR101394245B1 (ko) * | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2160020A1 (de) * | 1971-12-03 | 1973-06-07 | Bayer Ag | Perchlor-imidazo-pyrimidin, verfahren zu seiner herstellung, sowie seine verwendung als fungizid |
US4178449A (en) * | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
US4236005A (en) * | 1979-07-02 | 1980-11-25 | American Cyanamid Company | Imidazo[1,5-a]pyrimidines |
JPS6019789A (ja) * | 1983-07-12 | 1985-01-31 | Kyorin Pharmaceut Co Ltd | イミダゾ〔1,5−a〕ピリミジン誘導体 |
-
1984
- 1984-08-07 JP JP59165468A patent/JPS6143191A/ja active Granted
-
1985
- 1985-07-30 AU AU45617/85A patent/AU582377B2/en not_active Ceased
- 1985-07-31 HU HU852944A patent/HU192344B/hu not_active IP Right Cessation
- 1985-08-06 EP EP85109896A patent/EP0171739B1/en not_active Expired - Lifetime
- 1985-08-06 DK DK357285A patent/DK357285A/da not_active Application Discontinuation
- 1985-08-06 CA CA000488122A patent/CA1244019A/en not_active Expired
- 1985-08-06 DE DE8585109896T patent/DE3575305D1/de not_active Expired - Lifetime
- 1985-08-06 AT AT85109896T patent/ATE49411T1/de not_active IP Right Cessation
- 1985-08-06 KR KR1019850005653A patent/KR860001808A/ko not_active Application Discontinuation
- 1985-08-07 ES ES545973A patent/ES8609327A1/es not_active Expired
-
1986
- 1986-02-28 ES ES552544A patent/ES8705446A1/es not_active Expired
-
1989
- 1989-01-04 US US07/294,905 patent/US4914104A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1244019A (en) | 1988-11-01 |
ES8705446A1 (es) | 1987-05-01 |
AU582377B2 (en) | 1989-03-23 |
ES8609327A1 (es) | 1986-07-16 |
EP0171739A1 (en) | 1986-02-19 |
DK357285A (da) | 1986-02-08 |
US4914104A (en) | 1990-04-03 |
JPS6143191A (ja) | 1986-03-01 |
AU4561785A (en) | 1986-02-13 |
ATE49411T1 (de) | 1990-01-15 |
JPH0556352B2 (ko) | 1993-08-19 |
HUT38643A (en) | 1986-06-30 |
ES552544A0 (es) | 1987-05-01 |
HU192344B (en) | 1987-05-28 |
DE3575305D1 (de) | 1990-02-15 |
EP0171739B1 (en) | 1990-01-10 |
ES545973A0 (es) | 1986-07-16 |
DK357285D0 (da) | 1985-08-06 |
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