KR910007937A - 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법 - Google Patents

항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법 Download PDF

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Publication number
KR910007937A
KR910007937A KR1019890015203A KR890015203A KR910007937A KR 910007937 A KR910007937 A KR 910007937A KR 1019890015203 A KR1019890015203 A KR 1019890015203A KR 890015203 A KR890015203 A KR 890015203A KR 910007937 A KR910007937 A KR 910007937A
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South Korea
Prior art keywords
hydrogen
general formula
following general
group
halogen atom
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KR1019890015203A
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English (en)
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KR910009333B1 (ko
Inventor
김완주
박명환
오종훈
정명희
김봉진
Original Assignee
채영복
재단법인 한국화학연구소
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 채영복, 재단법인 한국화학연구소 filed Critical 채영복
Priority to KR1019890015203A priority Critical patent/KR910009333B1/ko
Priority to IN744/MAS/90A priority patent/IN171603B/en
Priority to FI905172A priority patent/FI905172A0/fi
Priority to HU906521A priority patent/HUT58102A/hu
Priority to NO90904552A priority patent/NO904552L/no
Priority to PT95641A priority patent/PT95641A/pt
Priority to AU64868/90A priority patent/AU6486890A/en
Priority to IL96080A priority patent/IL96080A0/xx
Priority to EP90120241A priority patent/EP0424851A1/en
Priority to CN90108603A priority patent/CN1052864A/zh
Priority to JP2282068A priority patent/JPH03193787A/ja
Priority to IE377990A priority patent/IE903779A1/en
Priority to MA22254A priority patent/MA21984A1/fr
Priority to ZA908427A priority patent/ZA908427B/xx
Priority to PL28745590A priority patent/PL287455A1/xx
Priority to YU198490A priority patent/YU198490A/sh
Priority to CA002028209A priority patent/CA2028209A1/en
Publication of KR910007937A publication Critical patent/KR910007937A/ko
Application granted granted Critical
Publication of KR910009333B1 publication Critical patent/KR910009333B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)

Abstract

내용 없음

Description

항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(I)로 표시되는 항균작용을 갖는 퀴놀린계 화합물 및 그의 염.
    윗 식에서, Z는 수소이거나 하로겐원자 또는 아미노기이고, R1은 수소이거나 알칼리금속 또는 알칼리토금속의 양이온이고, R2는 수소원자이거나 저급알킬기 또는 포르밀기이고, m은 1 내지 3의 정수이며, n은 1 또는 2이다.
  2. 다음 일반식(Ⅱ)로 표시되는 화합물과 다음 일반식(Ⅲ)으로 표시되는 디아자비시클로아민 화합물 또는 그의 산부가 물을 용매중에서 축합반응시켜서 되어짐을 특징으로 하는 다음 일반식(I)로 표시되는 퀴놀린계 화합물의 제조방법.
    윗 식(Ⅰ),(Ⅱ) 및 (Ⅲ)에서, Z는 수소이거나 할로겐원자 또는 아미노기이고, R1은 수소이거나 알칼리금속 또는 알칼리토금속의 양이온이고, R2는 수소원자이거나 저급알킬기 또는 포르밀기이고, m은 1 내지 3의 정수이고, n은 1 또는 2이고, R은 수소이거나 벤질 또는 토실기이며, L은 불소, 염소, 브롬 등의 할로겐원자이다.
  3. 제2항에 있어서, 상기 용매는 물, 알콜, 아세토니트릴, 디메틸포름아미드(DMF), 디메틸설폭시드(DMSO), 피리딘 및 피콜린 중에서 1종 이상을 선택하여서 됨을 특징으로 하는 상기 퀴놀린계 화합물의 제조방법.
  4. 유효성분으로서 다음 일반식(Ⅰ)로 표시되는 퀴놀린계 화합물을 적어도 1종 이상 함유하여서 된 것임을 특징으로 하는 항균제 조성물.
    윗 식에서, Z는 수소이거나 할로겐원자 또는 아미노기이고, R1은 수소이거나 알카리금속 또는 알카리토금속의 양이온이고, R2는 수소원자이거나 저급알킬기 또는 포르밀기이고, m은 1 내지 3의 정수이며, n은 1 또는 2이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890015203A 1989-10-23 1989-10-23 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법 KR910009333B1 (ko)

Priority Applications (17)

Application Number Priority Date Filing Date Title
KR1019890015203A KR910009333B1 (ko) 1989-10-23 1989-10-23 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
IN744/MAS/90A IN171603B (ko) 1989-10-23 1990-09-19
FI905172A FI905172A0 (fi) 1989-10-23 1990-10-19 Kinolonfoereningar oh foerfarande foer deras framstaellning.
HU906521A HUT58102A (en) 1989-10-23 1990-10-20 Process for producing quinolidine derivatives and pharmaceutical compositions comprising such compounds
IE377990A IE903779A1 (en) 1989-10-23 1990-10-22 Quinolone compounds and a process for their preparation
AU64868/90A AU6486890A (en) 1989-10-23 1990-10-22 Quinolone compounds and a process for their preparation
IL96080A IL96080A0 (en) 1989-10-23 1990-10-22 Quinolone compounds,a process for their preparation and compositions containing them
EP90120241A EP0424851A1 (en) 1989-10-23 1990-10-22 Quinolone compounds and a process for their preparation
NO90904552A NO904552L (no) 1989-10-23 1990-10-22 Quinolonforbindelser og fremgangsmaate for deres fremstilling.
JP2282068A JPH03193787A (ja) 1989-10-23 1990-10-22 キノロン化合物およびその製法
PT95641A PT95641A (pt) 1989-10-23 1990-10-22 Processo para a preparacao de compostos de quinolona e de composicoes farmaceuticas que os contem
MA22254A MA21984A1 (fr) 1989-10-23 1990-10-22 Procede pour la preparation de derives de quilinone .
ZA908427A ZA908427B (en) 1989-10-23 1990-10-22 Quinolone compounds and a process for their preparation
PL28745590A PL287455A1 (en) 1989-10-23 1990-10-22 Method of obtaining quinolone derivatives
YU198490A YU198490A (sh) 1989-10-23 1990-10-22 Kinolonske spojine in postopek za njihovo pripravo
CA002028209A CA2028209A1 (en) 1989-10-23 1990-10-22 Quinolone compounds and a process for their preparation
CN90108603A CN1052864A (zh) 1989-10-23 1990-10-22 喹诺酮化合物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890015203A KR910009333B1 (ko) 1989-10-23 1989-10-23 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법

Publications (2)

Publication Number Publication Date
KR910007937A true KR910007937A (ko) 1991-05-30
KR910009333B1 KR910009333B1 (ko) 1991-11-11

Family

ID=19290920

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890015203A KR910009333B1 (ko) 1989-10-23 1989-10-23 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법

Country Status (17)

Country Link
EP (1) EP0424851A1 (ko)
JP (1) JPH03193787A (ko)
KR (1) KR910009333B1 (ko)
CN (1) CN1052864A (ko)
AU (1) AU6486890A (ko)
CA (1) CA2028209A1 (ko)
FI (1) FI905172A0 (ko)
HU (1) HUT58102A (ko)
IE (1) IE903779A1 (ko)
IL (1) IL96080A0 (ko)
IN (1) IN171603B (ko)
MA (1) MA21984A1 (ko)
NO (1) NO904552L (ko)
PL (1) PL287455A1 (ko)
PT (1) PT95641A (ko)
YU (1) YU198490A (ko)
ZA (1) ZA908427B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220149771A (ko) * 2021-05-01 2022-11-08 삼도폴리텍 주식회사 물류보안인쇄부가 구비된 포장박스

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4339134A1 (de) * 1993-11-16 1995-05-18 Bayer Ag 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
PL2751083T3 (pl) * 2011-08-31 2018-08-31 Otsuka Pharmaceutical Co., Ltd. Związek chinolonowy
CN104098588B (zh) * 2013-04-02 2016-05-25 广州白云山医药集团股份有限公司白云山制药总厂 一类三环喹诺酮衍生物及其制备方法和用途
TW202244048A (zh) 2017-03-20 2022-11-16 美商佛瑪治療公司 作為丙酮酸激酶（ｐｋｒ）活化劑之吡咯并吡咯組成物
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220149771A (ko) * 2021-05-01 2022-11-08 삼도폴리텍 주식회사 물류보안인쇄부가 구비된 포장박스

Also Published As

Publication number Publication date
YU198490A (sh) 1993-10-20
CA2028209A1 (en) 1991-04-24
CN1052864A (zh) 1991-07-10
PL287455A1 (en) 1992-06-26
HUT58102A (en) 1992-01-28
FI905172A0 (fi) 1990-10-19
JPH03193787A (ja) 1991-08-23
IN171603B (ko) 1992-11-21
AU6486890A (en) 1991-04-26
EP0424851A1 (en) 1991-05-02
NO904552D0 (no) 1990-10-22
NO904552L (no) 1991-04-24
PT95641A (pt) 1991-09-13
HU906521D0 (en) 1991-04-29
MA21984A1 (fr) 1991-07-01
IE903779A1 (en) 1991-04-24
IL96080A0 (en) 1991-07-18
ZA908427B (en) 1991-08-28
KR910009333B1 (ko) 1991-11-11

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