DE69906492D1 - Fluorhaltige aminosäurederivate - Google Patents
Fluorhaltige aminosäurederivateInfo
- Publication number
- DE69906492D1 DE69906492D1 DE69906492T DE69906492T DE69906492D1 DE 69906492 D1 DE69906492 D1 DE 69906492D1 DE 69906492 T DE69906492 T DE 69906492T DE 69906492 T DE69906492 T DE 69906492T DE 69906492 D1 DE69906492 D1 DE 69906492D1
- Authority
- DE
- Germany
- Prior art keywords
- disturbance
- fluorine
- amino acid
- acid derivatives
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- 239000011737 fluorine Substances 0.000 title abstract 3
- -1 FLUORINE AMINO ACID DERIVATIVES Chemical class 0.000 title 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000003823 glutamate receptor agonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000004899 motility Effects 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1544498 | 1998-01-28 | ||
| PCT/JP1999/000324 WO1999038839A1 (fr) | 1998-01-28 | 1999-01-27 | Derives d'acides amines renfermant du fluor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906492D1 true DE69906492D1 (de) | 2003-05-08 |
| DE69906492T2 DE69906492T2 (de) | 2003-12-18 |
Family
ID=11888991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906492T Expired - Lifetime DE69906492T2 (de) | 1998-01-28 | 1999-01-27 | Fluorhaltige aminosäurederivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6316498B1 (de) |
| EP (1) | EP1052246B1 (de) |
| KR (1) | KR100446892B1 (de) |
| CN (1) | CN1182105C (de) |
| AT (1) | ATE236118T1 (de) |
| AU (1) | AU734812B2 (de) |
| CA (1) | CA2318800C (de) |
| DE (1) | DE69906492T2 (de) |
| DK (1) | DK1052246T3 (de) |
| ES (1) | ES2191412T3 (de) |
| HK (1) | HK1036792A1 (de) |
| PT (1) | PT1052246E (de) |
| WO (1) | WO1999038839A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1110943B1 (de) | 1998-08-31 | 2004-06-16 | Taisho Pharmaceutical Co. Ltd. | 6-fluoro[3.1.0]hexan-derivate |
| AU767592B2 (en) | 1998-12-18 | 2003-11-20 | Taisho Pharmaceutical Co., Ltd. | Intermediates and process for producing fluorine-containing amino acid compound by using the same |
| US20020188022A1 (en) * | 2000-10-30 | 2002-12-12 | Annovis. Inc. | Methods for modulation, stimulation, and inhibition of glutamate reuptake |
| HUP0400620A3 (en) * | 2001-01-11 | 2012-09-28 | Lilly Co Eli | Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds |
| EP1310480A1 (de) * | 2001-11-07 | 2003-05-14 | Eli Lilly & Company | Prodrugs von excitatorischen Aminosäuren |
| US7038077B2 (en) | 2001-01-11 | 2006-05-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| KR20030083732A (ko) * | 2001-03-14 | 2003-10-30 | 다이쇼 세이야꾸 가부시끼가이샤 | 비시클로카르복실산 유도체의 제조 방법 |
| US7456221B2 (en) | 2001-12-21 | 2008-11-25 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| NZ556437A (en) | 2002-06-11 | 2008-11-28 | Lilly Co Eli | Prodrugs of excitatory amino acids |
| EP2184062A1 (de) * | 2005-06-22 | 2010-05-12 | Ajinomoto Co., Inc. | Verwendung von Glutaminsäure und einer Nukleinsäure als metabotrope Glutamatrezeptoraktivatoren |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| NZ584145A (en) | 2007-09-14 | 2012-03-30 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones |
| EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
| EP2205565B1 (de) * | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituierte 4-(phenyl)-1h-pyridin-2-one |
| MX2010005110A (es) * | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. |
| ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| MX2011005242A (es) | 2008-11-28 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos. |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| CN103298809B (zh) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| AU2012271024B2 (en) | 2011-06-17 | 2015-07-09 | Eli Lilly And Company | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mGlu2 receptor agonist |
| EP2857385B1 (de) | 2012-06-01 | 2017-08-02 | Taisho Pharmaceutical Co., Ltd. | Prodrug aus fluorhaltiger aminosäure |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
| WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| CN105017048A (zh) * | 2015-07-01 | 2015-11-04 | 上海应用技术学院 | 一种含有四取代碳手性中心的α-氟烷基-α-氨基酸类化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750566A (en) | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
-
1999
- 1999-01-27 EP EP99901877A patent/EP1052246B1/de not_active Expired - Lifetime
- 1999-01-27 AU AU21835/99A patent/AU734812B2/en not_active Ceased
- 1999-01-27 DE DE69906492T patent/DE69906492T2/de not_active Expired - Lifetime
- 1999-01-27 WO PCT/JP1999/000324 patent/WO1999038839A1/ja active IP Right Grant
- 1999-01-27 CN CNB99804606XA patent/CN1182105C/zh not_active Expired - Fee Related
- 1999-01-27 DK DK99901877T patent/DK1052246T3/da active
- 1999-01-27 CA CA002318800A patent/CA2318800C/en not_active Expired - Fee Related
- 1999-01-27 AT AT99901877T patent/ATE236118T1/de active
- 1999-01-27 PT PT99901877T patent/PT1052246E/pt unknown
- 1999-01-27 KR KR10-2000-7008189A patent/KR100446892B1/ko not_active IP Right Cessation
- 1999-01-27 US US09/601,131 patent/US6316498B1/en not_active Expired - Lifetime
- 1999-01-27 ES ES99901877T patent/ES2191412T3/es not_active Expired - Lifetime
-
2001
- 2001-11-06 HK HK01107767A patent/HK1036792A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6316498B1 (en) | 2001-11-13 |
| CA2318800C (en) | 2005-12-20 |
| WO1999038839A1 (fr) | 1999-08-05 |
| DK1052246T3 (da) | 2003-06-16 |
| DE69906492T2 (de) | 2003-12-18 |
| HK1036792A1 (en) | 2002-01-18 |
| KR20010034418A (ko) | 2001-04-25 |
| CN1295557A (zh) | 2001-05-16 |
| EP1052246A4 (de) | 2001-11-07 |
| AU734812B2 (en) | 2001-06-21 |
| PT1052246E (pt) | 2003-06-30 |
| AU2183599A (en) | 1999-08-16 |
| KR100446892B1 (ko) | 2004-09-04 |
| CN1182105C (zh) | 2004-12-29 |
| EP1052246A1 (de) | 2000-11-15 |
| ES2191412T3 (es) | 2003-09-01 |
| EP1052246B1 (de) | 2003-04-02 |
| CA2318800A1 (en) | 1999-08-25 |
| ATE236118T1 (de) | 2003-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |