HUP0101220A2 - NMDA-receptor antagonista 1-(3-heteroaril-propil- vagy -prop-2-enil)-4-benzil-piperidinek, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás az előállításukra - Google Patents

NMDA-receptor antagonista 1-(3-heteroaril-propil- vagy -prop-2-enil)-4-benzil-piperidinek, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás az előállításukra

Info

Publication number
HUP0101220A2
HUP0101220A2 HU0101220A HUP0101220A HUP0101220A2 HU P0101220 A2 HUP0101220 A2 HU P0101220A2 HU 0101220 A HU0101220 A HU 0101220A HU P0101220 A HUP0101220 A HU P0101220A HU P0101220 A2 HUP0101220 A2 HU P0101220A2
Authority
HU
Hungary
Prior art keywords
disease
benzylpiperidines
enyl
prop
preparation
Prior art date
Application number
HU0101220A
Other languages
English (en)
Inventor
Andrew Barber
Gerd Bartoszyk
Joachim Leibrock
Helmut Prücher
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0101220A2 publication Critical patent/HUP0101220A2/hu
Publication of HUP0101220A3 publication Critical patent/HUP0101220A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya (I) általános képletű piperidinszármazékok ésfiziológiailag elfogadható sói - ahol X jelentése O, NR1, S vagy(CH2)n; Y jelentése CH; Z jelentése CH, ahol Y és Z együtt C=Cjelentésű is lehet; R1, R2, R3 jelentése egymástól függetlenülhidrogénatom vagy A; R4 jelentése hidrogénatom, Hal, A vagy OA; Ajelentése 1-6 szénatomos alkilcsoport; Hal jelentése fluor-, klór-,bróm- vagy jódatom; és n értéke 1, 2 vagy 3. A találmány szerintipiperidinszármazékokat és sóit serkentő funkciójú aminosav-antagonistaként alkalmazhatjuk neurodegeneratív rendellenességekgyógyítására, ideértve az agyér-megbetegedéseket, epilepsziát,skizofréniát, Alzheimer-kórt, Parkinson-kórt, Huntington-kórt, agyiiszchémiát, infarktust vagy pszichózist. A találmány tárgya továbbá avegyületeket tartalmazó gyógyszerkészítmények és előállításieljárásuk. Ó
HU0101220A 1998-03-20 1999-03-11 Nmda receptor antagonist 1-(3-heteroaryl propyl- or-prop-2-enyl)-4-benzylpiperidines, pharmaceutical compositions containing them and process for their preparation HUP0101220A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19812331A DE19812331A1 (de) 1998-03-20 1998-03-20 Piperidinderivate

Publications (2)

Publication Number Publication Date
HUP0101220A2 true HUP0101220A2 (hu) 2002-05-29
HUP0101220A3 HUP0101220A3 (en) 2003-08-28

Family

ID=7861717

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101220A HUP0101220A3 (en) 1998-03-20 1999-03-11 Nmda receptor antagonist 1-(3-heteroaryl propyl- or-prop-2-enyl)-4-benzylpiperidines, pharmaceutical compositions containing them and process for their preparation

Country Status (22)

Country Link
US (1) US6548516B1 (hu)
EP (1) EP1068202B1 (hu)
JP (1) JP4451565B2 (hu)
KR (1) KR20010042047A (hu)
CN (1) CN1123571C (hu)
AR (1) AR014747A1 (hu)
AT (1) ATE416173T1 (hu)
AU (1) AU747900B2 (hu)
BR (1) BR9908902A (hu)
CA (1) CA2324339C (hu)
DE (2) DE19812331A1 (hu)
DK (1) DK1068202T3 (hu)
ES (1) ES2316184T3 (hu)
HU (1) HUP0101220A3 (hu)
ID (1) ID26125A (hu)
NO (1) NO20004668D0 (hu)
PL (1) PL342732A1 (hu)
PT (1) PT1068202E (hu)
RU (1) RU2217429C2 (hu)
SK (1) SK13692000A3 (hu)
WO (1) WO1999048891A1 (hu)
ZA (1) ZA992191B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1286975B1 (en) 2000-05-31 2005-08-24 Warner-Lambert Company LLC Biclyclic cyclohexylamines and their use as nmda receptor antagonists
CA2407164A1 (en) 2000-06-06 2001-12-13 Warner-Lambert Company Bicyclic cyclohexylamines and their use as nmda receptor antagonists
EP1345935A2 (en) 2000-12-21 2003-09-24 Warner-Lambert Company LLC Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists
MXPA02002749A (es) 2001-03-27 2002-10-28 Warner Lambert Co Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato.
DE10248067A1 (de) * 2002-10-07 2004-04-15 Proteosys Ag Heteroarylpropyl-Piperazine und Heteroarylpropyl-Piperidine
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
MX2012006955A (es) * 2009-12-15 2012-12-05 Neurop Inc Compuestos para el tratamiento de trastornos neurologicos.
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
CN102791704B (zh) 2010-03-10 2015-11-25 前体生物药物股份公司 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
CN102133198B (zh) * 2011-03-09 2012-02-08 北京四环科宝制药有限公司 一种酒石酸艾芬地尔冻干粉针剂及其制备方法
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
CN103965188A (zh) * 2013-01-29 2014-08-06 中山大学 含硒多奈哌齐类似物
EP3288935B1 (en) * 2015-04-29 2019-10-30 Janssen Pharmaceutica NV Indolone compounds and their use as ampa receptor modulators
BR112017023147B1 (pt) 2015-04-29 2024-04-30 Rapport Therapeutics, Inc Derivados de azabenzimidazóis, seus usos como moduladores do receptor de ampa e composições farmacêuticas
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
TW281670B (hu) * 1993-09-02 1996-07-21 Hoffmann La Roche
FR2717810B1 (fr) * 1994-03-22 1996-04-26 Adir Nouvelles aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU3138595A (en) * 1994-07-20 1996-02-16 Acea Pharmaceuticals, Inc. Haloperidol analogs and the use thereof
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
DE19643790A1 (de) * 1996-10-30 1998-05-07 Merck Patent Gmbh Benzoxazol-Derivat

Also Published As

Publication number Publication date
NO20004668L (no) 2000-09-19
RU2217429C2 (ru) 2003-11-27
CA2324339A1 (en) 1999-09-30
ZA992191B (en) 1999-09-29
DE59914921D1 (de) 2009-01-15
SK13692000A3 (sk) 2001-02-12
CA2324339C (en) 2010-01-12
NO20004668D0 (no) 2000-09-19
CN1123571C (zh) 2003-10-08
ATE416173T1 (de) 2008-12-15
KR20010042047A (ko) 2001-05-25
HUP0101220A3 (en) 2003-08-28
AU3410599A (en) 1999-10-18
BR9908902A (pt) 2000-11-28
US6548516B1 (en) 2003-04-15
JP4451565B2 (ja) 2010-04-14
JP2002507613A (ja) 2002-03-12
DK1068202T3 (da) 2009-03-16
ID26125A (id) 2000-11-23
EP1068202B1 (de) 2008-12-03
DE19812331A1 (de) 1999-09-23
AU747900B2 (en) 2002-05-30
PT1068202E (pt) 2009-03-06
CN1293673A (zh) 2001-05-02
ES2316184T3 (es) 2009-04-01
PL342732A1 (en) 2001-07-02
EP1068202A1 (de) 2001-01-17
AR014747A1 (es) 2001-03-28
WO1999048891A1 (de) 1999-09-30

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