JPS6445400A - Human urinary trypsin inhibitor derivative and production thereof - Google Patents

Human urinary trypsin inhibitor derivative and production thereof

Info

Publication number
JPS6445400A
JPS6445400A JP63098801A JP9880188A JPS6445400A JP S6445400 A JPS6445400 A JP S6445400A JP 63098801 A JP63098801 A JP 63098801A JP 9880188 A JP9880188 A JP 9880188A JP S6445400 A JPS6445400 A JP S6445400A
Authority
JP
Japan
Prior art keywords
trypsin inhibitor
human urinary
cyanogen bromide
action
urinary trypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63098801A
Other languages
Japanese (ja)
Other versions
JPH0359079B2 (en
Inventor
Hideo Nishimaki
Tsunekazu Fukushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP63098801A priority Critical patent/JPS6445400A/en
Publication of JPS6445400A publication Critical patent/JPS6445400A/en
Publication of JPH0359079B2 publication Critical patent/JPH0359079B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A substance obtained by chemically modifying a human urinary trypsin inhibitor with cyanogen bromide and cleaving methionyl bonds. Molecular weight; 62,000+ or -5,000. Saccharide content (expressed in terms of glucose); 10%. Isoelectric point; pH2.5-4.5. USE:An anti-inflammatory remedy, having powerful antikallikrein and antihyaluronidase action and capable of exhibiting antithrombin action and anti-inflammatory action in a low concentration with low toxicity. PREPARATION:Cyanogen bromide in an amount of 0.1-20mg is added to 1mg human urinary trypsin inhibitor (hereinafter abbreviated to HUTI) and reacted at 10-50 deg.C for 1-60hr to separate a peptide without exhibiting trypsin inhibitory activity, methyl thiocyanate and excess cyanogen bromide and recover the aimed substance. Furthermore, the HUTI is preferably dissolved in 70% formic acid, etc., so as to provide 0.1-10%(wt./vol.) concentration.
JP63098801A 1988-04-21 1988-04-21 Human urinary trypsin inhibitor derivative and production thereof Granted JPS6445400A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63098801A JPS6445400A (en) 1988-04-21 1988-04-21 Human urinary trypsin inhibitor derivative and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63098801A JPS6445400A (en) 1988-04-21 1988-04-21 Human urinary trypsin inhibitor derivative and production thereof

Publications (2)

Publication Number Publication Date
JPS6445400A true JPS6445400A (en) 1989-02-17
JPH0359079B2 JPH0359079B2 (en) 1991-09-09

Family

ID=14229449

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63098801A Granted JPS6445400A (en) 1988-04-21 1988-04-21 Human urinary trypsin inhibitor derivative and production thereof

Country Status (1)

Country Link
JP (1) JPS6445400A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503241A (en) * 1997-06-03 2002-01-29 サントル・ナショナル・ドゥ・ラ・ルシェルシェ・シャンティフィク Coumarin derivatives, their production method and their use as pharmaceuticals

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118810A (en) * 1975-04-10 1976-10-19 Fujiwa Kako Kk A process for preparing proteolytic enzyme inhibitor from human urine
JPS51123810A (en) * 1975-04-03 1976-10-28 Green Cross Corp:The A process for preparing trypsin inhibitor from human urine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51123810A (en) * 1975-04-03 1976-10-28 Green Cross Corp:The A process for preparing trypsin inhibitor from human urine
JPS51118810A (en) * 1975-04-10 1976-10-19 Fujiwa Kako Kk A process for preparing proteolytic enzyme inhibitor from human urine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503241A (en) * 1997-06-03 2002-01-29 サントル・ナショナル・ドゥ・ラ・ルシェルシェ・シャンティフィク Coumarin derivatives, their production method and their use as pharmaceuticals

Also Published As

Publication number Publication date
JPH0359079B2 (en) 1991-09-09

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