PE20191615A1 - Compuestos quimicos como inhibidores de la actividad de la interleuquina-1 - Google Patents

Compuestos quimicos como inhibidores de la actividad de la interleuquina-1

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Publication number
PE20191615A1
PE20191615A1 PE2019001474A PE2019001474A PE20191615A1 PE 20191615 A1 PE20191615 A1 PE 20191615A1 PE 2019001474 A PE2019001474 A PE 2019001474A PE 2019001474 A PE2019001474 A PE 2019001474A PE 20191615 A1 PE20191615 A1 PE 20191615A1
Authority
PE
Peru
Prior art keywords
compounds
formulas
inhibitors
interleuquin
activity
Prior art date
Application number
PE2019001474A
Other languages
English (en)
Inventor
Jeffrey A Stafford
James M Veal
Lynnie Lin Trzoss
Christopher Mcbride
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20191615A1 publication Critical patent/PE20191615A1/es

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Abstract

La presente invencion se refiere a compuestos de sulfonilurea y sulfonil tiourea de Formulas (If), (Ig), (Ih) (Ie) o una sal farmaceuticamente aceptable de los mismos, en donde independientemente: X1 es O, S; R1 se selecciona de las formulas senaladas a continuacion; R2 es una de las formulas senaladas a continuacion; X2 es N o CR5b1; R3 y R4 son H. Dichos compuestos son inhibidores del inflamasoma NLRP3, ademas son eficaces en la modulacion de interleucinas y tienen propiedades fisicoquimicas y lipofilicidad deseables, para conseguir su eficacia terapeutica, siendo utiles para el tratamiento de trastornos hereditarios tales como los sindromes periodicos asociados a criopirina (CAPS) y enfermedades complejas tales como esclerosis multiple, diabetes de tipo II, enfermedad de Alzheimer y aterosclerosis. Tambien se refiere a una composicion farmaceutica que comprende dichos compuestos.
PE2019001474A 2017-01-23 2018-01-22 Compuestos quimicos como inhibidores de la actividad de la interleuquina-1 PE20191615A1 (es)

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