RU2020110366A - Новые соединения сульфонамидкарбоксамидов - Google Patents

Новые соединения сульфонамидкарбоксамидов Download PDF

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RU2020110366A
RU2020110366A RU2020110366A RU2020110366A RU2020110366A RU 2020110366 A RU2020110366 A RU 2020110366A RU 2020110366 A RU2020110366 A RU 2020110366A RU 2020110366 A RU2020110366 A RU 2020110366A RU 2020110366 A RU2020110366 A RU 2020110366A
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RU2020110366A
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RU2020110366A3 (ru
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Мэтью КУПЕР
Дэвид Миллер
Ангус МАКЛАУД
ВИЛТЕНБУРГ Джимми ВАН
Стивен Том
Стивен СТ-ГАЛЛАЙ
Джонатан ШЭННОН
Томас ЭЙЛАНИН
Стюарт ОНЬОНЗ
Иэн СТРАТ
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Инфлазоум Лимитед
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Priority claimed from GBGB1713082.4A external-priority patent/GB201713082D0/en
Priority claimed from GBGB1718563.8A external-priority patent/GB201718563D0/en
Priority claimed from GBGB1721726.6A external-priority patent/GB201721726D0/en
Priority claimed from GBGB1810983.5A external-priority patent/GB201810983D0/en
Application filed by Инфлазоум Лимитед filed Critical Инфлазоум Лимитед
Publication of RU2020110366A publication Critical patent/RU2020110366A/ru
Publication of RU2020110366A3 publication Critical patent/RU2020110366A3/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Claims (83)

1. Соединение формулы I:
Figure 00000001
,
где Q выбирают из О или S;
R1 представляет собой насыщенную или ненасыщенную гидрокарбильную группу, причем данная гидрокарбильная группа может быть с нормальной или разветвленной цепью, или представляет собой или включает циклические группы, причем гидрокарбильная группа может быть необязательно замещенной, и при том, что гидрокарбильная группа может необязательно содержать один или более гетероатомов N, О или S в своем углеродном скелете; и
R2 представляет собой циклическую группу, замещенную в α-положении одновалентной гетероциклической группой или одновалентной ароматической группой, причем кольцевой атом гетероциклической или ароматической группы непосредственно присоединен к кольцевому атому циклической группы, при этом гетероциклическая или ароматическая группа необязательно может быть замещена, и при том, что циклическая группа необязательно может быть дополнительно замещена.
2. Соединение по п. 1, где R1 представляет собой 4-10-членную циклическую группу, причем данная циклическая группа может необязательно быть замещена.
3. Соединение по п. 1, где R1 представляет собой С1-С15 алкильную, С2-С15 алкенильную или С2-С15 алкинильную группу, все из которых могут необязательно быть замещены, и все из которых могут необязательно содержать один, два или три гетероатома N, О или S в своем углеродном скелете.
4. Соединение по любому одному из пп. 1-3, где R1 замещена одним, двумя или тремя заместителями, независимо выбранными из галогена; -CN; -N3; -Rβ; -ОН; -ORβ; -SO2Rβ; -NH2; -NHRβ; -N(Rβ)2; -Rα-NH2; -Rα-NHRβ; -Rα-N(Rβ)2; -CORβ; -COORβ; -OCORβ; -Rα-CORβ; -Rα-COORβ; -Rα-OCORβ; -CONH2; -CONHRβ; -CON(Rβ)2; или оксо (=O);
где каждую -Rα- независимо выбирают из C1-C6 алкиленовой группы, причем один или два атома углерода в скелете алкиленовой группы могут необязательно быть заменены одним или двумя гетероатомами N, О или S, и при этом данная алкиленовая группа может необязательно быть замещена одним или двумя галогенами и/или группами -Rβ; и
где каждую -Rβ независимо выбирают из С1-С6 алкильной, С2-С6 алкенильной, С2-С6 алкинильной или С2-С6 циклической группой, причем, любая -Rβ может необязательно быть замещена одной, двумя или тремя С1-С4 алкильными, С1-С4 галогеналкильными, С3-С7 циклоалкильными, -O(C1-C4 алкильными), -O(C1-C4 галогеналкильными), -O(С3-С7 циклоалкильными), галогенами, -ОН, -NH2, -CN, -С=СН или оксо (=O) группами.
5. Соединение по любому одному из пп. 1-4, где α-замещенная циклическая группа R2 представляет собой 5- или 6-членную циклическую группу, причем данная циклическая группа может необязательно быть дополнительно замещена.
6. Соединение по любому одному из пп. 1-5, где одновалентная гетероциклическая или ароматическая группа в α-положении данной циклической группы R2 представляет собой фенильную или 5- или 6-членную гетероциклическую группу, все из которых могут необязательно быть замещены.
7. Соединение по любому одному из пп. 1-6, где одновалентная гетероциклическая или ароматическая группа в α-положении данной циклической группы R2 представляет собой фенил, пиридинил, пиримидинил или пиразолил, все из которых могут необязательно быть замещены одним или двумя заместителями, независимо выбранными из галогена, -ОН, -NH2, -CN, С1-С3 алкильной или -O(С1-С3 алкильной) групп.
8. Соединение по любому одному из пп. 1-7, где циклическая группа R2 дополнительно замещена одним или двумя заместителями, независимо выбранными из галогена, -Rδ, -ORδ или -CORδ групп, причем каждую Rδ независимо выбирают из C1-C6 алкильной, С2-С6 алкенильной, С2-С6 алкинильной или С2-С6 циклической группы, и при этом каждая Rδ необязательно дополнительно замещена одной или более группами галогенов.
9. Соединение по любому одному из пп. 1-8, где Q представляет собой О.
10. Соединение, выбранное из группы, состоящей из:
Figure 00000002
Figure 00000003
Figure 00000004
Figure 00000005
Figure 00000006
Figure 00000007
Figure 00000008
Figure 00000009
Figure 00000010
Figure 00000011
Figure 00000012
Figure 00000013
Figure 00000014
Figure 00000015
Figure 00000016
Figure 00000017
Figure 00000018
Figure 00000019
Figure 00000020
Figure 00000021
Figure 00000022
Figure 00000023
Figure 00000024
Figure 00000025
Figure 00000026
11. Фармацевтически приемлемая соль, сольват или пролекарство соединения по любому одному из пп. 1-10.
12. Фармацевтическая композиция, содержащая соединение по любому одному из пп. 1-10, или фармацевтически приемлемую соль, сольват или пролекарство по п. 11, и фармацевтически приемлемый эксципиент.
13. Фармацевтическая композиция по п. 12, отличающаяся тем, что данная фармацевтическая композиция представляет собой фармацевтическую композицию для местного применения.
14. Соединение по любому одному из пп. 1-10 или фармацевтически приемлемая соль, сольват или пролекарство по п. 11, или фармацевтическая композиция по п. 12 или 13 для применения в медицине.
15. Соединение, фармацевтически приемлемая соль, сольват, пролекарство или фармацевтическая композиция по п. 14 для применения в лечении или предотвращении заболевания, расстройства или патологического состояния, причем заболевание, расстройство или патологическое состояние отвечает на ингибирование NLRP3.
16. Соединение, фармацевтически приемлемая соль, сольват, пролекарство или фармацевтическая композиция по п. 14 или 15 для применения в лечении или предотвращении заболевания, расстройства или патологического состояния, причем заболевание, расстройство или патологическое состояние выбирают из:
(i) воспаления;
(ii) аутоиммунного заболевания;
(iii) рака;
(iv) инфекции;
(v) заболевания центральной нервной системы;
(vi) метаболического заболевания;
(vii) сердечно-сосудистого заболевания;
(viii) респираторного заболевания;
(ix) заболевания печени;
(x) заболевания почек;
(xi) глазного заболевания;
(xii) заболевания кожи;
(xiii) лимфатического заболевания;
(xiv) психологического расстройства;
(xv) болезни трансплантат против хозяина;
(xvi) аллодинии; а также
(xvii) любого заболевания, при котором у человека определено наличие зародышевой или соматической немолчащей мутации в NLRP3.
17. Соединение, фармацевтически приемлемая соль, сольват, пролекарство или фармацевтическая композиция по п. 14 или 15 для применения в лечении или предотвращении заболевания, расстройства или патологического состояния, причем заболевание, расстройство или патологическое состояние выбирают из:
(i) криопирин-ассоциированных периодических синдромов (CAPS);
(ii) синдрома Макла-Уэлльса (MWS);
(iii) семейного холодового аутовоспалительного синдрома (FCAS);
(iv) много системно го воспалительного заболевания новорожденных (NOMID);
(v) семейной средиземноморской лихорадки (FMF);
(vi) пиогенного артрита, синдрома гангренозной пиодермы и угрей (PAPA);
(vii) гипериммуноглобулинемии D и синдрома периодической лихорадки (HIDS);
(viii) периодического синдрома, связанного с рецептором фактора некроза опухоли (TNF) (TRAPS);
(ix) системного ювенильного идиопатического артрита;
(x) болезни Стилла у взрослых (AOSD);
(xi) рецидивирующего полихондрита;
(xii) синдрома Шницлера;
(xiii) синдрома Свита;
(xiv) болезни Бехчета;
(xv) антисинтетазного синдрома;
(xvi) дефицита антагониста рецептора интерлейкина 1 (DIRA); а также
(xvii) гаплонедостаточности А20 (НА20).
18. Способ ингибирования NLRP3, включающий применение соединения по любому одному из пп. 1-10 или фармацевтически приемлемой соли, сольвата или пролекарства по п. 11, или фармацевтической композиции по п. 12 или 13 для ингибирования NLRP3.
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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2739356C2 (ru) 2015-02-16 2020-12-23 Дзе Юниверсити Оф Квинсленд Сульфонилмочевины и родственные соединения и их применение
JP2019512009A (ja) 2016-02-16 2019-05-09 ザ・ユニバーシティ・オブ・クイーンズランド スルホニルウレアおよび関連化合物ならびにこれらの利用
MA47308A (fr) 2017-01-23 2019-11-27 Genentech Inc Composés chimiques comme inhibiteurs de l'activité interleukine-1
WO2018215818A1 (en) 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
JP7235742B2 (ja) 2017-07-07 2023-03-08 インフレイゾーム リミテッド 新規なスルホンアミドカルボキサミド化合物
EP3649112A1 (en) * 2017-07-07 2020-05-13 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
DE102017118230B4 (de) * 2017-08-10 2021-04-22 Christoph Lucks Verfahren zur Analyse und/oder Überwachung von Brücken sowie entsprechendes System und entsprechende Verwendung
US11542255B2 (en) 2017-08-15 2023-01-03 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668840A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
RU2020110394A (ru) 2017-08-15 2022-01-20 Инфлазоум Лимитед Новые соединения сульфонамидкарбоксамидов
KR20200041919A (ko) * 2017-08-15 2020-04-22 인플라좀 리미티드 Nlrp3 저해제로서의 설포닐유레아 및 설포닐티오유레아
JP2021502364A (ja) 2017-11-09 2021-01-28 インフレイゾーム リミテッド 新規なスルホンアミドカルボキサミド化合物
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
US12168653B2 (en) 2018-03-02 2024-12-17 Inflazome Limited Sulfonamide derivates as NLRP3 inhibitors
EP3759077A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
WO2019166627A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019166632A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019166628A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US12030879B2 (en) 2018-03-02 2024-07-09 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
CR20200588A (es) 2018-05-04 2021-06-24 Inflazome Ltd Compuestos novedosos
CN112584899A (zh) 2018-07-03 2021-03-30 诺华股份有限公司 Nlrp调节剂
SG11202012159TA (en) 2018-07-20 2021-01-28 Hoffmann La Roche Sulfonylurea compounds as inhibitors of interleukin-1 activity
SG11202013062VA (en) 2018-07-20 2021-02-25 Hoffmann La Roche Sulfonimidamide compounds as inhibitors of interleukin-1 activity
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
US12187702B2 (en) 2018-08-15 2025-01-07 Inflazome Limited Sulfonamideurea compounds
US20230011652A1 (en) 2018-10-24 2023-01-12 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
JP7682813B2 (ja) * 2019-06-12 2025-05-26 ノッドセラ リミテッド スルホニル尿素誘導体及びその使用
EP3986879B1 (en) 2019-06-21 2024-10-02 AC Immune SA Fused 1,2-thiazoles and 1,2-thiazines which act as nlrp3 modulators
US20220289766A1 (en) 2019-08-16 2022-09-15 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
CN114302876A (zh) 2019-09-06 2022-04-08 英夫拉索姆有限公司 Nlrp3抑制剂
BR112022009209A2 (pt) * 2019-11-12 2022-07-26 Chengdu Baiyu Pharmaceutical Co Ltd Derivado de amida e método de preparação e uso do mesmo na medicina
WO2021111351A1 (en) * 2019-12-03 2021-06-10 Cadila Healthcare Limited Novel substituted sulfonylurea and sulfoximineurea derivatives
JP2023513935A (ja) 2020-02-18 2023-04-04 インフレイゾーム リミテッド 化合物
JP2023529867A (ja) 2020-06-05 2023-07-12 キネート バイオファーマ インク． 線維芽細胞増殖因子受容体キナーゼの阻害剤
CN115768749B (zh) * 2020-06-11 2024-04-19 辰欣药业股份有限公司 二甲基亚磺酰亚胺衍生物
CA3178361A1 (en) 2020-06-19 2021-12-23 Emanuele Gabellieri Dihydrooxazole and thiourea derivatives modulating the nlrp3 inflammasome pathway
US20230348437A1 (en) * 2020-07-02 2023-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
WO2022237782A1 (zh) * 2021-05-10 2022-11-17 成都百裕制药股份有限公司 酰胺衍生物及其应用
CN116635374B (zh) * 2021-05-10 2025-05-06 康百达（四川）生物医药科技有限公司 酰胺衍生物及其应用
IL308071A (en) * 2021-06-23 2023-12-01 Hoffmann La Roche Process for preparing NLRP3 inhibitors
MX2024003948A (es) * 2021-09-29 2024-06-28 Viva Star Biosciences Suzhou Co Ltd Nuevos compuestos de sulfonilurea sustituidos como inhibidores de la actividad de interleucina-1.
CN115894478B (zh) * 2021-09-30 2025-04-04 杭州民生药物研究院有限公司 一种新型吡啶并吡唑类杂环化合物及其应用
JP2024523690A (ja) * 2021-12-02 2024-06-28 上▲海▼栖臻医▲薬▼科技有限公司 芳香族化合物、その医薬組成物及びその使用
EP4452972A1 (en) 2021-12-22 2024-10-30 AC Immune SA Dihydro-oxazol derivative compounds
CN118871426A (zh) * 2022-02-15 2024-10-29 豪夫迈·罗氏有限公司 用于制备1,2,3,5,6,7-六氢-s-二环戊二烯并苯衍生物的方法
US12338255B2 (en) 2022-02-21 2025-06-24 Viva Star Biosciences (Suzhou) Co., Ltd. Bicyclic substituted sulfonylurea compounds as inhibitors of interleukin-1 activity
US20250283896A1 (en) * 2022-04-25 2025-09-11 Vanderbilt University Probes and methods for targeted visualization of nlrp3 inflammasomes
AU2023307538A1 (en) 2022-07-14 2025-01-23 Ac Immune Sa Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
WO2024023266A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa Novel compounds
AR130151A1 (es) * 2022-08-10 2024-11-06 Takeda Pharmaceuticals Co Compuesto heterocíclico
WO2024249539A1 (en) 2023-06-02 2024-12-05 Merck Sharp & Dohme Llc 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3
GB202319256D0 (en) 2023-12-15 2024-01-31 Amphista Therapeutics Ltd Novel compounds for targeted protein degradation
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025153624A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025153625A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB797474A (en) * 1955-07-20 1958-07-02 Boehringer & Soehne Gmbh Sulphonylurea derivatives
NL129208C (ru) * 1965-07-14
DE4039733A1 (de) * 1990-12-13 1992-06-17 Basf Ag Substituierte 5-aminopyrazole
AU2494792A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
AU2496492A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
JPH06199047A (ja) * 1993-01-08 1994-07-19 New Oji Paper Co Ltd 感熱記録体
WO1997011057A1 (en) * 1995-09-22 1997-03-27 E.I. Du Pont De Nemours And Company Arthropodicidal 1,4-dihydropyridines and 1,4-dihydropyrimidines
WO1997030978A1 (fr) * 1996-02-26 1997-08-28 Sumitomo Pharmaceuticals Company, Limited Derives de sulfonylureidopyrazole
CZ20013248A3 (cs) * 1999-03-15 2002-04-17 Axys Pharmaceuticals, Inc. Nové sloučeniny a prostředky jako inhibitory proteázy
GB0017676D0 (en) * 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CA2369967A1 (en) * 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
BR0209855A (pt) * 2001-05-18 2004-06-15 Solvay Pharm Gmbh Uso de compostos com atividade inibidora de nep/mp combinada na preparação de medicamentos
FI110677B (fi) * 2001-10-12 2003-03-14 Jujo Thermal Oy Lämpöherkkä tallennusmateriaali
DK1441734T3 (da) * 2001-10-26 2007-06-11 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase
ZA200408711B (en) * 2002-05-28 2006-10-25 Dimensional Pharamaceuticals I Novel thiophene amidines, composition thereof, and methods of treating complement-mediated diseases and conditions
WO2006085815A1 (en) * 2005-02-11 2006-08-17 Astrazeneca Ab Thiazole derivatives, their process for their preparation and their use in therapy
EP1874788A1 (en) * 2005-04-19 2008-01-09 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory and/or anti-cancer agents
US8486987B2 (en) * 2007-11-16 2013-07-16 University Of Medicine And Dentistry Of New Jersey Mechanism-based small-molecule parasite inhibitors
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
PL221813B1 (pl) * 2013-02-22 2016-05-31 Univ Medyczny W Lublinie Pochodne 1-arylo-6-benzenosulfonyloimidazo[1,2-a][1,3,5] triazyny oraz sposób ich otrzymywania
RU2739356C2 (ru) * 2015-02-16 2020-12-23 Дзе Юниверсити Оф Квинсленд Сульфонилмочевины и родственные соединения и их применение
FR3046933B1 (fr) * 2016-01-25 2018-03-02 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires
US10080741B2 (en) * 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
JP7235742B2 (ja) * 2017-07-07 2023-03-08 インフレイゾーム リミテッド 新規なスルホンアミドカルボキサミド化合物
EP3668843A1 (en) * 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
KR20200041919A (ko) * 2017-08-15 2020-04-22 인플라좀 리미티드 Nlrp3 저해제로서의 설포닐유레아 및 설포닐티오유레아
RU2020110394A (ru) * 2017-08-15 2022-01-20 Инфлазоум Лимитед Новые соединения сульфонамидкарбоксамидов
US11542255B2 (en) * 2017-08-15 2023-01-03 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
EP3668840A1 (en) * 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds

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