CR9815A - Compuestos de imidazol para el tratamiento de transtornos neurologicos - Google Patents

Compuestos de imidazol para el tratamiento de transtornos neurologicos

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Publication number
CR9815A
CR9815A CR9815A CR9815A CR9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A
Authority
CR
Costa Rica
Prior art keywords
compounds
neurological disorders
treatment
formula
imidazol compounds
Prior art date
Application number
CR9815A
Other languages
English (en)
Inventor
Aaren Brodney Michael
Liang Chen Yuhpyng
Jean Coffman Karen
Fox Kleinman Edward
Thomas O'neill Brian
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR9815A publication Critical patent/CR9815A/es

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a los compuestos de formula I, en la que R1, R2, R3, R4, R6, R7, y A son como se ha definido. Los compuestos de la formula I tienen actividad en la inhibicion de la produccion de AB-peptidos. La invencion tambien se refiere a las composiciones farmaceuticas y procedimientos para tratar enfermedades y trastornos, por ejemplo, trastornos neurodegenerativos y / o neurologicos, por ejemplo enfermedad de Alzheimer, en un mamifero que comprende los compuestos de la formula I.
CR9815A 2005-09-22 2008-03-13 Compuestos de imidazol para el tratamiento de transtornos neurologicos CR9815A (es)

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US71952105P 2005-09-22 2005-09-22

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CR9815A true CR9815A (es) 2008-04-16

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US (2) US7781435B2 (es)
EP (1) EP1940802A2 (es)
JP (1) JP2009508934A (es)
KR (1) KR20080040010A (es)
CN (1) CN101282941A (es)
AR (1) AR055205A1 (es)
AU (1) AU2006293619A1 (es)
BR (1) BRPI0616141A2 (es)
CA (1) CA2619068A1 (es)
CR (1) CR9815A (es)
EA (1) EA200800659A1 (es)
EC (1) ECSP088280A (es)
GT (1) GT200600425A (es)
IL (1) IL189524A0 (es)
MA (1) MA29793B1 (es)
NL (1) NL1032552C2 (es)
NO (1) NO20081845L (es)
PE (1) PE20070617A1 (es)
RS (1) RS20080139A (es)
TN (1) TNSN08138A1 (es)
TW (1) TW200804300A (es)
UY (1) UY29806A1 (es)
WO (1) WO2007034326A2 (es)

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SG11201710694YA (en) * 2015-06-22 2018-01-30 Sumitomo Dainippon Pharma Co Ltd Bicyclic heterocyclic amide derivative
JP6896701B2 (ja) 2016-02-26 2021-06-30 大日本住友製薬株式会社 イミダゾリルアミド誘導体
TW202328068A (zh) * 2021-09-01 2023-07-16 美商斯普林渥克斯治療有限公司 尼羅司他（ｎｉｒｏｇａｃｅｓｔａｔ）之合成

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NL1032552A1 (nl) 2007-03-23
US7781435B2 (en) 2010-08-24
NO20081845L (no) 2008-06-19
AU2006293619A1 (en) 2007-03-29
NL1032552C2 (nl) 2007-09-25
TNSN08138A1 (fr) 2009-07-14
AR055205A1 (es) 2007-08-08
IL189524A0 (en) 2008-08-07
MA29793B1 (fr) 2008-09-01
CA2619068A1 (en) 2007-03-29
UY29806A1 (es) 2007-04-30
BRPI0616141A2 (pt) 2011-06-07
US20100184737A1 (en) 2010-07-22
ECSP088280A (es) 2008-04-28
EA200800659A1 (ru) 2008-08-29
WO2007034326A2 (en) 2007-03-29
EP1940802A2 (en) 2008-07-09
US20070066613A1 (en) 2007-03-22
JP2009508934A (ja) 2009-03-05
PE20070617A1 (es) 2007-07-18
CN101282941A (zh) 2008-10-08
TW200804300A (en) 2008-01-16
GT200600425A (es) 2007-05-08
RS20080139A (en) 2009-05-06
KR20080040010A (ko) 2008-05-07

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