MA29793B1 - Derives d'imidazole pour le traitement de troubles neurologiques. - Google Patents

Derives d'imidazole pour le traitement de troubles neurologiques.

Info

Publication number
MA29793B1
MA29793B1 MA30767A MA30767A MA29793B1 MA 29793 B1 MA29793 B1 MA 29793B1 MA 30767 A MA30767 A MA 30767A MA 30767 A MA30767 A MA 30767A MA 29793 B1 MA29793 B1 MA 29793B1
Authority
MA
Morocco
Prior art keywords
treatment
neurological disorders
imidazole derivatives
compounds
formula
Prior art date
Application number
MA30767A
Other languages
English (en)
Inventor
Michael Aaron Brodney
Yuhpyng Liang Chen
Karen Jean Coffman
Edward Fox Kleinman
Brian Thomas O'neill
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA29793B1 publication Critical patent/MA29793B1/fr

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Dérivés d'imidazole pour le traitement de troubles neurologiques La présente invention concerne des composés de formule (I) dans laquelle R1, R2, R3, R4, R6, R7 et A répondent aux définitions indiquées. Les composés de formule (I) ont une activité d'inhibition de la production du peptide A(bêta). La présente invention concerne également des compositions pharmaceutiques et méthodes pour le traitement de maladies et troubles, par exemple de troubles neurodégénératifs et/ou neurologiques, par exemple de la maladie d'Alzheimer, chez un mammifère, comprenant des composés de formule (I).
MA30767A 2005-09-22 2008-03-19 Derives d'imidazole pour le traitement de troubles neurologiques. MA29793B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71952105P 2005-09-22 2005-09-22

Publications (1)

Publication Number Publication Date
MA29793B1 true MA29793B1 (fr) 2008-09-01

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Application Number Title Priority Date Filing Date
MA30767A MA29793B1 (fr) 2005-09-22 2008-03-19 Derives d'imidazole pour le traitement de troubles neurologiques.

Country Status (23)

Country Link
US (2) US7781435B2 (fr)
EP (1) EP1940802A2 (fr)
JP (1) JP2009508934A (fr)
KR (1) KR20080040010A (fr)
CN (1) CN101282941A (fr)
AR (1) AR055205A1 (fr)
AU (1) AU2006293619A1 (fr)
BR (1) BRPI0616141A2 (fr)
CA (1) CA2619068A1 (fr)
CR (1) CR9815A (fr)
EA (1) EA200800659A1 (fr)
EC (1) ECSP088280A (fr)
GT (1) GT200600425A (fr)
IL (1) IL189524A0 (fr)
MA (1) MA29793B1 (fr)
NL (1) NL1032552C2 (fr)
NO (1) NO20081845L (fr)
PE (1) PE20070617A1 (fr)
RS (1) RS20080139A (fr)
TN (1) TNSN08138A1 (fr)
TW (1) TW200804300A (fr)
UY (1) UY29806A1 (fr)
WO (1) WO2007034326A2 (fr)

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CN1934091B (zh) * 2004-03-23 2012-02-08 辉瑞产品公司 治疗神经变性障碍的咪唑化合物
JP2009508934A (ja) * 2005-09-22 2009-03-05 ファイザー・プロダクツ・インク 神経障害治療のためのイミダゾール化合物
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
CN107922348A (zh) * 2015-06-22 2018-04-17 大日本住友制药株式会社 双环杂环酰胺衍生物
US10898469B2 (en) 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative
AR126961A1 (es) * 2021-09-01 2023-12-06 Springworks Therapeutics Inc Sintesis de nirogacestat

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CR9815A (es) 2008-04-16
WO2007034326A3 (fr) 2007-08-30
TW200804300A (en) 2008-01-16
AR055205A1 (es) 2007-08-08
ECSP088280A (es) 2008-04-28
CN101282941A (zh) 2008-10-08
AU2006293619A1 (en) 2007-03-29
CA2619068A1 (fr) 2007-03-29
JP2009508934A (ja) 2009-03-05
PE20070617A1 (es) 2007-07-18
IL189524A0 (en) 2008-08-07
NO20081845L (no) 2008-06-19
TNSN08138A1 (fr) 2009-07-14
EA200800659A1 (ru) 2008-08-29
BRPI0616141A2 (pt) 2011-06-07
RS20080139A (en) 2009-05-06
US7781435B2 (en) 2010-08-24
WO2007034326A2 (fr) 2007-03-29
US20070066613A1 (en) 2007-03-22
GT200600425A (es) 2007-05-08
NL1032552A1 (nl) 2007-03-23
KR20080040010A (ko) 2008-05-07
EP1940802A2 (fr) 2008-07-09
UY29806A1 (es) 2007-04-30
US20100184737A1 (en) 2010-07-22

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