PE20070617A1 - Compuestos de imidazol para el tratamiento de trastornos neurologicos - Google Patents

Compuestos de imidazol para el tratamiento de trastornos neurologicos

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Publication number
PE20070617A1
PE20070617A1 PE2006001139A PE2006001139A PE20070617A1 PE 20070617 A1 PE20070617 A1 PE 20070617A1 PE 2006001139 A PE2006001139 A PE 2006001139A PE 2006001139 A PE2006001139 A PE 2006001139A PE 20070617 A1 PE20070617 A1 PE 20070617A1
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PE
Peru
Prior art keywords
alkyl
treatment
neurological disorders
cycloalkyl
imidazole compounds
Prior art date
Application number
PE2006001139A
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English (en)
Inventor
Michael Aaron Brodney
Yuhpyng Liang Chen
Edward Fox Kleinman
Brian Thomas O'neill
Karen Jean Coffman
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20070617A1 publication Critical patent/PE20070617A1/es

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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  • Chemical & Material Sciences (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES C=O, SO2, -Z-C=O, ENTRE OTROS; Z ES CH2, -CH(OH), -CH(ALQUILO C1-C6), ENTRE OTROS; R1 ES ALQUILO C1-C20, ALQUENILO C2-C20, ALQUINILO C2-C20, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, HALO; R6 ES H, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R7 ES ALQUILO C1-C20 SUSTITUIDO CON CICLOALQUILO C3-C12, CICLOALQUENILO C4-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {1-[2-(3-ETOXI-PROPILAMINO)-ETIL]-1H-IMIDAZOL-4-IL}AMIDA DEL ACIDO (S)-2-[2-(3,5-DIFLUORO-FENIL)ACETILAMINO]-PENTANOICO; {1-[2-(OCTAHIDRO-PIRAZINO[1,2-a]AZEPIN-2-IL)ETIL]-1H-IMIDAZOL-4-IL}AMIDA DEL ACIDO (S)-2-[2-(3,5-DIFLUORO-FENIL)ACETILAMINO]-PENTANOICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE Aß-PEPTIDOS, UTILES EN EL TRATAMIENTO DE TRASTORNOS NEURODEGENERATIVOS Y/O NEUROLOGICOS TAL COMO EL ALZHEIMER
PE2006001139A 2005-09-22 2006-09-20 Compuestos de imidazol para el tratamiento de trastornos neurologicos PE20070617A1 (es)

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US71952105P 2005-09-22 2005-09-22

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US (2) US7781435B2 (es)
EP (1) EP1940802A2 (es)
JP (1) JP2009508934A (es)
KR (1) KR20080040010A (es)
CN (1) CN101282941A (es)
AR (1) AR055205A1 (es)
AU (1) AU2006293619A1 (es)
BR (1) BRPI0616141A2 (es)
CA (1) CA2619068A1 (es)
CR (1) CR9815A (es)
EA (1) EA200800659A1 (es)
EC (1) ECSP088280A (es)
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IL (1) IL189524A0 (es)
MA (1) MA29793B1 (es)
NL (1) NL1032552C2 (es)
NO (1) NO20081845L (es)
PE (1) PE20070617A1 (es)
RS (1) RS20080139A (es)
TN (1) TNSN08138A1 (es)
TW (1) TW200804300A (es)
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WO (1) WO2007034326A2 (es)

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EA011689B1 (ru) * 2004-03-23 2009-04-28 Пфайзер Продактс Инк. Имидазольные соединения для лечения нейродегенеративных расстройств
EA200800659A1 (ru) * 2005-09-22 2008-08-29 Пфайзер Продактс Инк. Соединения имидазола для лечения неврологических нарушений
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
KR20180030545A (ko) * 2015-06-22 2018-03-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 바이사이클릭 헤테로사이클릭 아미드 유도체
WO2017146128A1 (ja) 2016-02-26 2017-08-31 大日本住友製薬株式会社 イミダゾリルアミド誘導体
CN118043305A (zh) * 2021-09-01 2024-05-14 斯普林渥克斯治疗有限公司 尼洛加司他的合成

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401851A (en) 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
JPH07101958A (ja) 1992-10-16 1995-04-18 Takeda Chem Ind Ltd セフェム化合物、その製造法および抗菌組成物
DE19629816A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
ZA987385B (en) 1997-08-19 2000-04-18 Lilly Co Eli Growth hormone secretagogues.
ZA987383B (en) 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
CO5160260A1 (es) 1999-02-19 2002-05-30 Lilly Co Eli Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
DE10019755A1 (de) 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
AU2001264977B2 (en) 2000-05-30 2005-04-14 Merck & Co., Inc. Melanocortin receptor agonists
GT200100147A (es) * 2000-07-31 2002-06-25 Derivados de imidazol
AU2002223500A1 (en) 2000-11-17 2002-05-27 Novo-Nordisk A/S Glucagon antagonists/inverse agonists
TW200301698A (en) 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
KR101018318B1 (ko) 2001-12-21 2011-03-04 노보 노르디스크 에이/에스 Ｇｋ 활성제로서의 아미드 유도체
US20040063735A1 (en) 2002-06-05 2004-04-01 Chaturvedula Prasad V. Calcitonin gene related peptide receptor antagonists
JP2004089937A (ja) 2002-09-03 2004-03-25 Seiwa Pro:Kk 食品破砕処理装置及びこれを備えた食品分解処理装置
WO2004033434A1 (en) 2002-10-09 2004-04-22 Pfizer Products Inc. Pyrazole compounds for treatment of neurodegenerative disorders
WO2004033439A1 (en) 2002-10-09 2004-04-22 Pfizer Products Inc. Thiazole compounds for the treatment of neurodegenerative disorders
JP2006182648A (ja) 2003-04-08 2006-07-13 Dai Ichi Seiyaku Co Ltd ７員複素環誘導体
BRPI0409721A (pt) 2003-05-12 2006-05-02 Pfizer Prod Inc compostos de isoxazol e isotiazol para o tratamento de distúrbios neurodegenerativos
MXPA06001320A (es) 2003-08-01 2006-05-04 Pfizer Prod Inc Compuestos heteroarilo de 6 miembros para el tratamiento de trastornos neurodegenerativos.
EP1653952A4 (en) 2003-08-06 2007-04-04 Pfizer Prod Inc OXAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEEGENERATIVE DISORDER
BRPI0413709A (pt) 2003-08-21 2006-10-17 Pfizer Prod Inc compostos para o tratamento de distúrbios neurodegenerativos
GB0329275D0 (en) * 2003-12-18 2004-01-21 Merck Sharp & Dohme Therapeutic treatment
EA011689B1 (ru) * 2004-03-23 2009-04-28 Пфайзер Продактс Инк. Имидазольные соединения для лечения нейродегенеративных расстройств
US20050222227A1 (en) 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
US7163942B2 (en) 2004-04-01 2007-01-16 Pfizer Inc. Sulfonamide compounds for the treatment of neurodegenerative disorders
US7220865B2 (en) 2004-04-01 2007-05-22 Pfizer Inc Isoxazole-and isothiazole-amine compounds for the treatment of neurodegenerative disorders
US7309709B2 (en) 2004-04-01 2007-12-18 Pfizer Inc. Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
US7232820B2 (en) 2004-04-01 2007-06-19 Pfizer Inc Thiadiazole-amine compounds for the treatment of neurodegenerative disorders
US7384968B2 (en) 2004-04-01 2008-06-10 Pfizer Inc. Thiazole-amine compounds for the treatment of neurodegenerative disorders
EA200800659A1 (ru) * 2005-09-22 2008-08-29 Пфайзер Продактс Инк. Соединения имидазола для лечения неврологических нарушений

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