UY31986A - Derivados n- sustituídos de la 2-metil-propionamida;{1-[5-sustiuido-4-sustituido-tiazol-2-il-carbamoil]-1-metil-etil} amidas de ácidos carboxílicos sustituidos, derivados farmacéuticamente aceptables de los mismos, composiciones y aplicaciones. - Google Patents
Derivados n- sustituídos de la 2-metil-propionamida;{1-[5-sustiuido-4-sustituido-tiazol-2-il-carbamoil]-1-metil-etil} amidas de ácidos carboxílicos sustituidos, derivados farmacéuticamente aceptables de los mismos, composiciones y aplicaciones.Info
- Publication number
- UY31986A UY31986A UY0001031986A UY31986A UY31986A UY 31986 A UY31986 A UY 31986A UY 0001031986 A UY0001031986 A UY 0001031986A UY 31986 A UY31986 A UY 31986A UY 31986 A UY31986 A UY 31986A
- Authority
- UY
- Uruguay
- Prior art keywords
- substituted
- methyl
- compositions
- sustiuded
- carbamoil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a los compuestos de la fórmula (I): en donde A es un heteroarilo opcionalmente sustituido, útiles para el tratamiento de los trastornos mediados por acil-transferasa de acil-CoA-diacil-glicerol 1 (DGAT1), por ejemplo, trastornos metabólicos. La invención también proporciona métodos para el tratamiento de estos trastornos, y los compuestos y composiciones etc. para su tratamiento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8091308P | 2008-07-15 | 2008-07-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31986A true UY31986A (es) | 2010-02-26 |
Family
ID=41136646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001031986A UY31986A (es) | 2008-07-15 | 2009-07-15 | Derivados n- sustituídos de la 2-metil-propionamida;{1-[5-sustiuido-4-sustituido-tiazol-2-il-carbamoil]-1-metil-etil} amidas de ácidos carboxílicos sustituidos, derivados farmacéuticamente aceptables de los mismos, composiciones y aplicaciones. |
Country Status (23)
Country | Link |
---|---|
US (1) | US8703761B2 (es) |
EP (4) | EP2559455A1 (es) |
JP (1) | JP5401544B2 (es) |
KR (1) | KR20110028661A (es) |
CN (1) | CN102119047B (es) |
AR (1) | AR072559A1 (es) |
AU (1) | AU2009272826A1 (es) |
BR (1) | BRPI0916216A2 (es) |
CA (1) | CA2731097A1 (es) |
CL (1) | CL2011000087A1 (es) |
CO (1) | CO6341581A2 (es) |
CR (1) | CR20110013A (es) |
EA (1) | EA201100189A1 (es) |
EC (1) | ECSP11010830A (es) |
IL (1) | IL210292A0 (es) |
MA (1) | MA32558B1 (es) |
MX (1) | MX2011000628A (es) |
NZ (1) | NZ590285A (es) |
PE (1) | PE20110105A1 (es) |
SV (1) | SV2011003809A (es) |
TW (1) | TW201006832A (es) |
UY (1) | UY31986A (es) |
WO (1) | WO2010007046A2 (es) |
Families Citing this family (19)
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AR066169A1 (es) * | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
EP2334651A2 (en) * | 2008-07-24 | 2011-06-22 | Theravance, Inc. | Dual-acting antihypertensive agents |
US20120015938A1 (en) * | 2009-02-17 | 2012-01-19 | Msd K.K. | 1,4-benzodiazepin-2-on derivatives |
WO2014054053A1 (en) * | 2012-10-03 | 2014-04-10 | Advinus Therapeutics Limited | Spirocyclic compounds, compositions and medicinal applications thereof |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
TWI691486B (zh) | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
EP3568135B1 (en) | 2017-01-11 | 2021-04-07 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
CN110913859A (zh) | 2017-07-27 | 2020-03-24 | 东丽株式会社 | 圆形脱毛症的治疗剂或预防剂 |
JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
JP2021512166A (ja) * | 2018-01-30 | 2021-05-13 | フォグホーン セラピューティクス インコーポレイテッドFoghorn Therapeutics Inc. | 化合物及びその使用 |
TWI805699B (zh) | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
AR114465A1 (es) | 2018-04-04 | 2020-09-09 | Japan Tobacco Inc | Compuestos de pirazol sustituidos con heteroarilo y su utilización farmacéutica |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN115335373A (zh) * | 2020-01-29 | 2022-11-11 | 福宏治疗公司 | 化合物及其用途 |
IL295177A (en) | 2020-01-29 | 2022-09-01 | Foghorn Therapeutics Inc | compounds and their uses |
US11459310B2 (en) | 2020-10-22 | 2022-10-04 | Landos Biopharma, Inc. | LANCL ligands |
TWD226926S (zh) | 2022-09-21 | 2023-08-11 | 精誠軟體服務股份有限公司 | 電腦程式之具變化外觀之圖形化使用者介面 |
TWD226927S (zh) | 2022-09-21 | 2023-08-11 | 精誠軟體服務股份有限公司 | 電腦程式之具變化外觀之圖形化使用者介面 |
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-
2009
- 2009-07-14 KR KR1020117003370A patent/KR20110028661A/ko not_active Application Discontinuation
- 2009-07-14 EA EA201100189A patent/EA201100189A1/ru unknown
- 2009-07-14 JP JP2011517900A patent/JP5401544B2/ja not_active Expired - Fee Related
- 2009-07-14 PE PE2011000039A patent/PE20110105A1/es not_active Application Discontinuation
- 2009-07-14 BR BRPI0916216A patent/BRPI0916216A2/pt not_active IP Right Cessation
- 2009-07-14 CN CN200980131154.1A patent/CN102119047B/zh not_active Expired - Fee Related
- 2009-07-14 EP EP12160875A patent/EP2559455A1/en not_active Withdrawn
- 2009-07-14 EP EP12180191A patent/EP2548618A3/en not_active Withdrawn
- 2009-07-14 TW TW098123761A patent/TW201006832A/zh unknown
- 2009-07-14 US US12/502,669 patent/US8703761B2/en not_active Expired - Fee Related
- 2009-07-14 MX MX2011000628A patent/MX2011000628A/es not_active Application Discontinuation
- 2009-07-14 WO PCT/EP2009/058960 patent/WO2010007046A2/en active Application Filing
- 2009-07-14 AU AU2009272826A patent/AU2009272826A1/en not_active Abandoned
- 2009-07-14 EP EP11164200A patent/EP2380631A1/en not_active Withdrawn
- 2009-07-14 AR ARP090102662A patent/AR072559A1/es not_active Application Discontinuation
- 2009-07-14 NZ NZ590285A patent/NZ590285A/xx not_active IP Right Cessation
- 2009-07-14 CA CA2731097A patent/CA2731097A1/en not_active Abandoned
- 2009-07-14 EP EP09780542A patent/EP2349484A2/en not_active Withdrawn
- 2009-07-15 UY UY0001031986A patent/UY31986A/es not_active Application Discontinuation
-
2010
- 2010-12-27 IL IL210292A patent/IL210292A0/en unknown
-
2011
- 2011-01-10 CR CR20110013A patent/CR20110013A/es not_active Application Discontinuation
- 2011-01-14 CL CL2011000087A patent/CL2011000087A1/es unknown
- 2011-01-17 SV SV2011003809A patent/SV2011003809A/es unknown
- 2011-02-11 MA MA33609A patent/MA32558B1/fr unknown
- 2011-02-15 EC EC2011010830A patent/ECSP11010830A/es unknown
- 2011-02-18 CO CO11019986A patent/CO6341581A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0916216A2 (pt) | 2018-03-13 |
AU2009272826A1 (en) | 2010-01-21 |
CN102119047A (zh) | 2011-07-06 |
AR072559A1 (es) | 2010-09-08 |
CN102119047B (zh) | 2014-09-24 |
CO6341581A2 (es) | 2011-11-21 |
US8703761B2 (en) | 2014-04-22 |
US20100022513A1 (en) | 2010-01-28 |
NZ590285A (en) | 2012-10-26 |
MA32558B1 (fr) | 2011-08-01 |
EP2548618A3 (en) | 2013-02-27 |
JP2011528016A (ja) | 2011-11-10 |
WO2010007046A3 (en) | 2010-07-22 |
EP2548618A2 (en) | 2013-01-23 |
PE20110105A1 (es) | 2011-02-25 |
EP2559455A1 (en) | 2013-02-20 |
CR20110013A (es) | 2011-02-11 |
WO2010007046A2 (en) | 2010-01-21 |
MX2011000628A (es) | 2011-02-25 |
EP2349484A2 (en) | 2011-08-03 |
CA2731097A1 (en) | 2010-01-21 |
EP2380631A1 (en) | 2011-10-26 |
ECSP11010830A (es) | 2011-03-31 |
IL210292A0 (en) | 2011-03-31 |
EA201100189A1 (ru) | 2011-08-30 |
KR20110028661A (ko) | 2011-03-21 |
JP5401544B2 (ja) | 2014-01-29 |
CL2011000087A1 (es) | 2011-07-01 |
SV2011003809A (es) | 2011-07-05 |
TW201006832A (en) | 2010-02-16 |
Similar Documents
Publication | Publication Date | Title |
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