UY29806A1 - Compuestos de imidazol para el tratamiento de trastornos neurológicos - Google Patents

Compuestos de imidazol para el tratamiento de trastornos neurológicos

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Publication number
UY29806A1
UY29806A1 UY29806A UY29806A UY29806A1 UY 29806 A1 UY29806 A1 UY 29806A1 UY 29806 A UY29806 A UY 29806A UY 29806 A UY29806 A UY 29806A UY 29806 A1 UY29806 A1 UY 29806A1
Authority
UY
Uruguay
Prior art keywords
compounds
neurological disorders
treatment
formula
imidazol compounds
Prior art date
Application number
UY29806A
Other languages
English (en)
Inventor
Brian Thomas O Neill
Edward Fox Kleinman
Yuhpyng Liang Chen
Michael Aaron Brodney
Karen Jean Coffman
Original Assignee
Pfizer Prod Inc
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Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY29806A1 publication Critical patent/UY29806A1/es

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

La presente invención se refiere a los compuestos de fórmula I en la que R1, R2, R3. R4, R6, R7, y A son como se han definido. Los compuestos de la fórmula I tienen actividad en la inhibición de la producción de AB(Beta)-péptidos. La invención también se refiere a las composiciones farmacéuticas y procedimientos para tratar enfermedades y trastornos, por ejemplo, trastornos neurodegenerativos y/o neurológicos, por ejemplo enfermedad de Alzheimer, en un mamífero que comprende los compuestos de la fórmula I.
UY29806A 2005-09-22 2006-09-22 Compuestos de imidazol para el tratamiento de trastornos neurológicos UY29806A1 (es)

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US (2) US7781435B2 (es)
EP (1) EP1940802A2 (es)
JP (1) JP2009508934A (es)
KR (1) KR20080040010A (es)
CN (1) CN101282941A (es)
AR (1) AR055205A1 (es)
AU (1) AU2006293619A1 (es)
BR (1) BRPI0616141A2 (es)
CA (1) CA2619068A1 (es)
CR (1) CR9815A (es)
EA (1) EA200800659A1 (es)
EC (1) ECSP088280A (es)
GT (1) GT200600425A (es)
IL (1) IL189524A0 (es)
MA (1) MA29793B1 (es)
NL (1) NL1032552C2 (es)
NO (1) NO20081845L (es)
PE (1) PE20070617A1 (es)
RS (1) RS20080139A (es)
TN (1) TNSN08138A1 (es)
TW (1) TW200804300A (es)
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WO (1) WO2007034326A2 (es)

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CA2990564A1 (en) * 2015-06-22 2016-12-29 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic heterocyclic amide derivative
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KR20080040010A (ko) 2008-05-07
RS20080139A (en) 2009-05-06
TNSN08138A1 (fr) 2009-07-14
US20100184737A1 (en) 2010-07-22
WO2007034326A3 (en) 2007-08-30
US7781435B2 (en) 2010-08-24
CA2619068A1 (en) 2007-03-29
EA200800659A1 (ru) 2008-08-29
US20070066613A1 (en) 2007-03-22
JP2009508934A (ja) 2009-03-05
PE20070617A1 (es) 2007-07-18
CN101282941A (zh) 2008-10-08
WO2007034326A2 (en) 2007-03-29
BRPI0616141A2 (pt) 2011-06-07
IL189524A0 (en) 2008-08-07
EP1940802A2 (en) 2008-07-09
MA29793B1 (fr) 2008-09-01
ECSP088280A (es) 2008-04-28
CR9815A (es) 2008-04-16
NL1032552A1 (nl) 2007-03-23
NL1032552C2 (nl) 2007-09-25
GT200600425A (es) 2007-05-08
AU2006293619A1 (en) 2007-03-29
TW200804300A (en) 2008-01-16
NO20081845L (no) 2008-06-19

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