CO5160260A1 - Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido - Google Patents

Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido

Info

Publication number
CO5160260A1
CO5160260A1 CO00011043A CO00011043A CO5160260A1 CO 5160260 A1 CO5160260 A1 CO 5160260A1 CO 00011043 A CO00011043 A CO 00011043A CO 00011043 A CO00011043 A CO 00011043A CO 5160260 A1 CO5160260 A1 CO 5160260A1
Authority
CO
Colombia
Prior art keywords
substituted
secretagogos
dazol
imi
hormone
Prior art date
Application number
CO00011043A
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
Iii Charles Willis Lugar
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5160260A1 publication Critical patent/CO5160260A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Un compuesto de fórmula<EMI FILE="00011043_1" ID="1" IMF=JPEG >En la que R1 es C6H5CH2OCH2-, C6H5(CH2)3- o indol-3-ilmetilo;Y es pirrolidinilo, 4-metilpiperidinilo o NR2R2;R2 son cada uno independientemente un alquilo C1 a C6;R3 es 2-naftilo o fenilo para sustituido con W;W es H, F, CF3, alcoxi C1-C6 o fenilo y R4 es H o CH3o una sal o solvato farmacéuticamente aceptable del mismo.
CO00011043A 1999-02-19 2000-02-17 Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido CO5160260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12081399P 1999-02-19 1999-02-19

Publications (1)

Publication Number Publication Date
CO5160260A1 true CO5160260A1 (es) 2002-05-30

Family

ID=22392709

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00011043A CO5160260A1 (es) 1999-02-19 2000-02-17 Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido

Country Status (13)

Country Link
EP (1) EP1153034B1 (es)
JP (1) JP2002539089A (es)
CN (1) CN1179972C (es)
AR (1) AR023369A1 (es)
AT (1) ATE375996T1 (es)
AU (1) AU765642B2 (es)
BR (1) BR0008321A (es)
CA (1) CA2362303A1 (es)
CO (1) CO5160260A1 (es)
DE (1) DE60036785D1 (es)
IL (1) IL144350A0 (es)
PE (1) PE20001468A1 (es)
WO (1) WO2000049037A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
AU6497701A (en) 2000-05-30 2001-12-11 Merck & Co Inc Melanocortin receptor agonists
US6756385B2 (en) * 2000-07-31 2004-06-29 Pfizer Inc. Imidazole derivatives
GT200100147A (es) * 2000-07-31 2002-06-25 Derivados de imidazol
WO2002032878A1 (en) * 2000-10-13 2002-04-25 Eli Lilly And Company Resolution process for preparation of substantially pure (r) and (s) enantiomers of 2-(4-nitroimidazolyl)-4-methoxyphenylpropionic acid and salts thereof
WO2002058708A1 (en) 2001-01-23 2002-08-01 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
WO2003087069A2 (en) * 2002-04-09 2003-10-23 Eli Lilly And Company Dipeptidic growth hormone secretagogues
CN1934091B (zh) * 2004-03-23 2012-02-08 辉瑞产品公司 治疗神经变性障碍的咪唑化合物
BRPI0616141A2 (pt) 2005-09-22 2011-06-07 Pfizer Prod Inc compostos imidazol para o tratamento de distúrbios neurológicos
US10590087B1 (en) 2019-08-09 2020-03-17 Pfizer Inc. Solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide and uses thereof
US11884634B2 (en) 2019-08-09 2024-01-30 Pfizer Inc. Compositions of solid forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4- tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
US11504354B1 (en) 2021-09-08 2022-11-22 SpringWorks Therapeutics Inc.. Chlorinated tetralin compounds and pharmaceutical compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107836A (en) * 1992-12-11 1998-01-04 Merck & Co Inc Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them
HUT72076A (en) * 1992-12-11 1996-03-28 Merck & Co Inc Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them
US5721250A (en) * 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
ZA987385B (en) * 1997-08-19 2000-04-18 Lilly Co Eli Growth hormone secretagogues.
ZA987383B (en) * 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.

Also Published As

Publication number Publication date
DE60036785D1 (de) 2007-11-29
AU3496800A (en) 2000-09-04
CN1347420A (zh) 2002-05-01
CN1179972C (zh) 2004-12-15
JP2002539089A (ja) 2002-11-19
PE20001468A1 (es) 2000-12-20
ATE375996T1 (de) 2007-11-15
AU765642B2 (en) 2003-09-25
IL144350A0 (en) 2002-05-23
AR023369A1 (es) 2002-09-04
EP1153034B1 (en) 2007-10-17
WO2000049037A1 (en) 2000-08-24
CA2362303A1 (en) 2000-08-24
EP1153034A1 (en) 2001-11-14
BR0008321A (pt) 2002-01-29

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