CO5261596A1 - Derivados de cromano como compuestos estrogenicos, y su uso en la fabricacion de medicamentos para tratamientos relaionados con los receptores de estrogenos - Google Patents

Derivados de cromano como compuestos estrogenicos, y su uso en la fabricacion de medicamentos para tratamientos relaionados con los receptores de estrogenos

Info

Publication number
CO5261596A1
CO5261596A1 CO01016343A CO01016343A CO5261596A1 CO 5261596 A1 CO5261596 A1 CO 5261596A1 CO 01016343 A CO01016343 A CO 01016343A CO 01016343 A CO01016343 A CO 01016343A CO 5261596 A1 CO5261596 A1 CO 5261596A1
Authority
CO
Colombia
Prior art keywords
strogen
medicines
receivers
manufacture
estrogenic compounds
Prior art date
Application number
CO01016343A
Other languages
English (en)
Inventor
Hernan Veeneman Gerrit
Miranda Teerhuis Neeltje
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5261596A1 publication Critical patent/CO5261596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Abstract

Un compuesto de cromano CARACTERIZADO porque tienen la fórmula 1:<EMI FILE="01016343_1" ID="1" IMF=JPEG >DondeR1 es (1C-4C)alquilo, (2C-4C)alquenilo o (2C-4C)alquinilo, e independientemente R1 tiene una orientación cis en relación con el grupo fenilo exocíclico en la posición 2 del esqueleto;R4 es Hal, CF3, OH ó (1C-2C)alquiloxi;R2, R3, y R5 son independientemente H, Hal, CF3, (1C-4C)-alquilo, (2C-4C)alquenilo o (2C-4C) alquinilo; o (2C-4C)alquinilo;O un profármaco del mismo.
CO01016343A 2000-03-01 2001-03-01 Derivados de cromano como compuestos estrogenicos, y su uso en la fabricacion de medicamentos para tratamientos relaionados con los receptores de estrogenos CO5261596A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00200713 2000-03-01

Publications (1)

Publication Number Publication Date
CO5261596A1 true CO5261596A1 (es) 2003-03-31

Family

ID=8171123

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01016343A CO5261596A1 (es) 2000-03-01 2001-03-01 Derivados de cromano como compuestos estrogenicos, y su uso en la fabricacion de medicamentos para tratamientos relaionados con los receptores de estrogenos

Country Status (9)

Country Link
US (3) US7214706B2 (es)
EP (1) EP1282615B1 (es)
JP (1) JP4896335B2 (es)
AR (1) AR027571A1 (es)
AT (1) ATE529419T1 (es)
AU (1) AU2001256164A1 (es)
CO (1) CO5261596A1 (es)
PE (1) PE20011077A1 (es)
WO (1) WO2001064665A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1448544T1 (sl) * 2001-11-19 2007-10-31 Lilly Co Eli Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta
PL205733B1 (pl) * 2001-11-19 2010-05-31 Lilly Co Eli Podstawiona pochodna benzopiranu, kompozycja farmaceutyczna ją zawierająca oraz jej zastosowanie
US6630508B1 (en) 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists
AU2003212856A1 (en) * 2002-03-01 2003-09-16 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
PT1626974E (pt) 2003-04-21 2008-11-14 Lilly Co Eli Benzopiranos substituídos como agonistas selectivos do receptor beta de estrogénio
US7279499B2 (en) 2003-04-21 2007-10-09 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
AU2005282554A1 (en) 2004-09-07 2006-03-16 Wyeth 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
WO2006044176A1 (en) 2004-10-18 2006-04-27 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
WO2008091555A2 (en) 2007-01-22 2008-07-31 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US8063102B2 (en) 2009-03-13 2011-11-22 N.V. Organon Tetrahydronaphthalen-2-ol derivatives
TW201043595A (en) * 2009-03-13 2010-12-16 Organon Nv Tetrahydronaphthalen-2-ol derivatives
EP3490653A1 (en) 2016-07-28 2019-06-05 Cerebral Therapeutics Implantable intraventricular sampling and infusion access device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
DE1543749A1 (de) * 1966-02-16 1969-12-11 Merck Ag E Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5280040A (en) 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
HUP9702244A3 (en) * 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
ATE231141T1 (de) * 1996-10-28 2003-02-15 Novo Nordisk As (-)-enantiomere von cis-3,4-chromanderivaten zur vorbeugung oder behandlungvon oestrogenbezogenen krankheiten oder syndromen
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

Also Published As

Publication number Publication date
WO2001064665A1 (en) 2001-09-07
US7214706B2 (en) 2007-05-08
AU2001256164A1 (en) 2001-09-12
AR027571A1 (es) 2003-04-02
US7846966B2 (en) 2010-12-07
ATE529419T1 (de) 2011-11-15
EP1282615B1 (en) 2011-10-19
US20060160889A1 (en) 2006-07-20
US7531571B2 (en) 2009-05-12
JP2003525285A (ja) 2003-08-26
US20030069303A1 (en) 2003-04-10
EP1282615A1 (en) 2003-02-12
JP4896335B2 (ja) 2012-03-14
US20090221695A1 (en) 2009-09-03
PE20011077A1 (es) 2001-12-12

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