AR033525A1 - Arilmetilaminas sustituidas, composiciones farmaceuticas, uso de las mismas para la manufactura de un medicamento - Google Patents

Arilmetilaminas sustituidas, composiciones farmaceuticas, uso de las mismas para la manufactura de un medicamento

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Publication number
AR033525A1
AR033525A1 ARP010102009A ARP010102009A AR033525A1 AR 033525 A1 AR033525 A1 AR 033525A1 AR P010102009 A ARP010102009 A AR P010102009A AR P010102009 A ARP010102009 A AR P010102009A AR 033525 A1 AR033525 A1 AR 033525A1
Authority
AR
Argentina
Prior art keywords
ny1y2
heteroaryl
alkyl
alkoxy
hydroxy
Prior art date
Application number
ARP010102009A
Other languages
English (en)
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0012362.0A external-priority patent/GB0012362D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of AR033525A1 publication Critical patent/AR033525A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Se proveen arilmetilaminas sustituidas, que comprenden un compuesto de formula (1), en la que Ar es un grupo arilo o un grupo heteroarilo, y el grupo de formula (2) es beta con respecto al grupo de formula (3), en el arilo, donde: la línea de puntos es un enlace simple o doble; R1 y R2 son cada uno independientemente hidrogeno o alquilo inferior; R3 es arilo, arilalquenilo, cicloalquenilo, cicloalquilo, heteroarilo, heteroaril-alquenilo, heterocicloalquenilo, un heterocicloalquilo ligado a carbono o alquilo opcionalmente substituido con uno o más grupos seleccionados entre hidroxi, alcoxi, alquiloxicarbonilamino, cicloalquilo, heterocicloalquilo, R6, -OR6, -S(O)mR6 o -C(=O)-R6; R4 es hidrogeno, acilo, alcoxi, alquiloxicarbonilo, carboxi, ciano, halo, hidroxi, -C(=O)-NY1Y2 o alquilo opcionalmente substituido con alcoxi, alquilcarbonilamino, alquilsulfonilamino, hidroxi, -S(O)m-alquilo o -NY1Y2; R5 es hidrogeno, acilo, alcoxi, alquiloxicarbonilo, arilo, carboxi, ciano, halo, heteroarilo, heteroariloxi, heterocicloalquilo, heterocicloalquiloxi, heterocicloalquilalquiloxi, heteroarilalquiloxi, hidroxi, trifluormetilo, -C(=O)-NY1Y2, -NY1Y2, -Z1-C2-6alquileno-R7 o alquilo opcionalmente substituido con alcoxi, alquilcarbonilamino, alquilsulfonilamino, arilo, heteroarilo, heterocicloalquilo, hidroxi, ureido, -C(=O)-NY1Y2, -SO2-NY1Y2, -S(O)m-alquilo o -NY1Y2; R6 es arilo o heteroarilo; R7 es hidroxi, alcoxi, ureido, -C(=O)-NY1Y2, -SO2-NY1Y2, -S(O)m-alquilo o -NY1Y2; R8 es hidrogeno o alquilo inferior; Y1 e Y2 son independientemente hidrogeno, alquenilo, alquilo, arilo, arilalquilo, cicloalquilo, heteroarilo, heteroarilalquilo o heterocicloalquilo o el grupo -NY1Y2 puede formar una amina cíclica; Z1 es O, S(O)m o NR8; m es cero o un numero entero de 1 a 2; n es cero o un numero entero de 1 a 4; un N-oxido de dicho compuesto, una prodroga de dicho compuesto, una sal farmacéuticamente aceptable de dicho compuesto, un solvato de dicho compuesto, y un hidrato de dicho compuesto que tienen actividad de inhibicion de triptasa, composiciones farmacéuticas que comprenden dichos compuestos, y el uso de los mismos para la manufactura de un medicamento para tratar sujetos que sufren de una condicion, enfermedad, o un desorden que puede ser mejorado mediante la administracion de un inhibidor de triptasa, por ejemplo asma y enfermedades inflamatorias, para nombrar unas pocas de entre ellas.
ARP010102009A 2000-05-22 2001-04-27 Arilmetilaminas sustituidas, composiciones farmaceuticas, uso de las mismas para la manufactura de un medicamento AR033525A1 (es)

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