PE20030697A1 - Derivados de tetrahidrobenzofluoreno - Google Patents
Derivados de tetrahidrobenzofluorenoInfo
- Publication number
- PE20030697A1 PE20030697A1 PE2002001231A PE2002001231A PE20030697A1 PE 20030697 A1 PE20030697 A1 PE 20030697A1 PE 2002001231 A PE2002001231 A PE 2002001231A PE 2002001231 A PE2002001231 A PE 2002001231A PE 20030697 A1 PE20030697 A1 PE 20030697A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- derivatives
- hydroxy
- tetrahidrobenzofluoreno
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A DERIVADOS DE TETRAHIDROBENZOFLUORENO DE FORMULA I DONDE EL SUSTITUYENTE O-(CH2)n-N(R1R2) EN EL ANILLO PUEDE ESTAR EN POSICION META O PARA; n ES 2-4; Re Y Re' SON OH, R1 Y R2 SON ALQUILO, ALQUENILO, HIDROXI-ALQUILO, ALCOXI-ALQUILO, ARILO-ALQUILO O JUNTO A N FORMA UN HETEROCICLO OPCIONALMENTE SUSTITUIDO CON ALQUILO, ALQUENILO, HIDROXI-ALQUILO, ALCOXI-ALQUILO, ARILO. LOS COMPUESTOS SON ANTAGONISTAS DE RECEPTORES DE ESTROGENOS ß Y PUEDEN SER UTILES PARA ALIVIAR LOS MALESTARES TIPICOS ASOCIADOS CON LA MENOPAUSIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01205206 | 2001-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030697A1 true PE20030697A1 (es) | 2003-08-18 |
Family
ID=8181558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001231A PE20030697A1 (es) | 2001-12-21 | 2002-12-13 | Derivados de tetrahidrobenzofluoreno |
Country Status (11)
Country | Link |
---|---|
US (2) | US7304155B2 (es) |
EP (1) | EP1458743B1 (es) |
JP (1) | JP5054882B2 (es) |
AR (1) | AR038035A1 (es) |
AT (1) | ATE382628T1 (es) |
AU (1) | AU2002358715A1 (es) |
DE (1) | DE60224441T2 (es) |
ES (1) | ES2298414T3 (es) |
PE (1) | PE20030697A1 (es) |
TW (1) | TW200408385A (es) |
WO (1) | WO2003053994A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200408385A (en) * | 2001-12-21 | 2004-06-01 | Akzo Nobel Nv | Tetrahydrobenzfluorene derivatives |
WO2008091555A2 (en) | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
WO2001072713A1 (en) | 2000-03-27 | 2001-10-04 | Akzo Nobel N.V. | Non-steroidal, tetracyclic compounds for estrogen-related treatments |
TW200408385A (en) * | 2001-12-21 | 2004-06-01 | Akzo Nobel Nv | Tetrahydrobenzfluorene derivatives |
-
2002
- 2002-11-29 TW TW091134824A patent/TW200408385A/zh unknown
- 2002-12-13 PE PE2002001231A patent/PE20030697A1/es not_active Application Discontinuation
- 2002-12-16 EP EP02793020A patent/EP1458743B1/en not_active Expired - Lifetime
- 2002-12-16 ES ES02793020T patent/ES2298414T3/es not_active Expired - Lifetime
- 2002-12-16 WO PCT/EP2002/014283 patent/WO2003053994A1/en active IP Right Grant
- 2002-12-16 DE DE60224441T patent/DE60224441T2/de not_active Expired - Lifetime
- 2002-12-16 JP JP2003554710A patent/JP5054882B2/ja not_active Expired - Fee Related
- 2002-12-16 US US10/499,956 patent/US7304155B2/en not_active Expired - Lifetime
- 2002-12-16 AU AU2002358715A patent/AU2002358715A1/en not_active Abandoned
- 2002-12-16 AT AT02793020T patent/ATE382628T1/de not_active IP Right Cessation
- 2002-12-19 AR ARP020104991A patent/AR038035A1/es unknown
-
2007
- 2007-10-25 US US11/924,507 patent/US7655653B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60224441T2 (de) | 2008-12-11 |
AR038035A1 (es) | 2004-12-22 |
DE60224441D1 (de) | 2008-02-14 |
US7655653B2 (en) | 2010-02-02 |
US7304155B2 (en) | 2007-12-04 |
AU2002358715A1 (en) | 2003-07-09 |
EP1458743A1 (en) | 2004-09-22 |
US20050119264A1 (en) | 2005-06-02 |
ES2298414T3 (es) | 2008-05-16 |
WO2003053994A1 (en) | 2003-07-03 |
US20080058361A1 (en) | 2008-03-06 |
JP2005518387A (ja) | 2005-06-23 |
JP5054882B2 (ja) | 2012-10-24 |
ATE382628T1 (de) | 2008-01-15 |
TW200408385A (en) | 2004-06-01 |
EP1458743B1 (en) | 2008-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |