CO5080742A1 - Derivados de fenil esteres de -amino acidos y su uso como hipnoticos para la induccion y mantencion de la anestesia general - Google Patents

Derivados de fenil esteres de -amino acidos y su uso como hipnoticos para la induccion y mantencion de la anestesia general

Info

Publication number
CO5080742A1
CO5080742A1 CO99045953A CO99045953A CO5080742A1 CO 5080742 A1 CO5080742 A1 CO 5080742A1 CO 99045953 A CO99045953 A CO 99045953A CO 99045953 A CO99045953 A CO 99045953A CO 5080742 A1 CO5080742 A1 CO 5080742A1
Authority
CO
Colombia
Prior art keywords
alkyl
alkyloxy
esteres
fenil
hypnotics
Prior art date
Application number
CO99045953A
Other languages
English (en)
Inventor
N M Niall Morton Hamilton
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5080742A1 publication Critical patent/CO5080742A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un derivado de fenil éster de -a-amino ácido CARACTERIZADO porque tiene la fórmula general (I):<EMI FILE="99045953_1" ID="1" IMF=JPEG >dondeR1 es (C1-3 ) alquiloxi;R2 es (C1-3 ) alquilo, (C1-3 )alquiloxi ó (C2-3 )alquenilo;R3 es hidrógeno, (C1-3)alquilo, (C1-3)alquiloxi ó (C2-3 )alquenilo,R4 es (C1-6 )alquilo;R5 y R6 son independientemente (C1-6 )alquilo, (C2-6 ) alquenilo, (C2-6 )alquilino o aralquilo, cada uno de los cuales puede estar opcionalmente sustituido con (C1-3 )alquiloxi, (C1-3 )alquiloxi carbonilo, ciano ó NR7 R8 ;R7 y R8 son independientemente (C1-6 )alquilo;o una sal farmacéuticamente aceptable del mismo, con la exclusión de 2,6-dimetoxifenil 2-(dietilamino)propionato y 2,6-dimetoxifenil 2-(dietilamino)butirato.
CO99045953A 1998-07-22 1999-07-21 Derivados de fenil esteres de -amino acidos y su uso como hipnoticos para la induccion y mantencion de la anestesia general CO5080742A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98305837 1998-07-22

Publications (1)

Publication Number Publication Date
CO5080742A1 true CO5080742A1 (es) 2001-09-25

Family

ID=8234960

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99045953A CO5080742A1 (es) 1998-07-22 1999-07-21 Derivados de fenil esteres de -amino acidos y su uso como hipnoticos para la induccion y mantencion de la anestesia general

Country Status (27)

Country Link
US (1) US6451854B1 (es)
EP (1) EP1098871B1 (es)
JP (1) JP2002521358A (es)
KR (1) KR100599142B1 (es)
CN (1) CN1183101C (es)
AR (1) AR021165A1 (es)
AT (1) ATE244697T1 (es)
AU (1) AU758808B2 (es)
BR (1) BR9912291A (es)
CA (1) CA2337945A1 (es)
CO (1) CO5080742A1 (es)
DE (1) DE69909486T2 (es)
DK (1) DK1098871T3 (es)
ES (1) ES2203163T3 (es)
HU (1) HUP0102705A3 (es)
ID (1) ID27261A (es)
IL (1) IL140586A (es)
NO (1) NO20010280L (es)
NZ (1) NZ509327A (es)
PE (1) PE20000880A1 (es)
PL (1) PL345621A1 (es)
PT (1) PT1098871E (es)
RU (1) RU2223947C2 (es)
SK (1) SK1032001A3 (es)
TR (1) TR200100166T2 (es)
TW (1) TW565546B (es)
WO (1) WO2000005196A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR031473A1 (es) * 2000-11-20 2003-09-24 Lundbeck & Co As H Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide
ATE328864T1 (de) 2001-01-19 2006-06-15 Akzo Nobel Nv Alanin-2,6-dialkoxyphenylesterderivate als hypnotika

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1102011A (en) 1964-05-21 1968-02-07 Richardson Merrell Spa Phenol esters of amino acids
GB1160468A (en) 1967-05-08 1969-08-06 May & Baker Ltd Morpholine Derivative

Also Published As

Publication number Publication date
IL140586A (en) 2004-06-01
TW565546B (en) 2003-12-11
AR021165A1 (es) 2002-07-03
AU758808B2 (en) 2003-03-27
AU5160299A (en) 2000-02-14
CN1311770A (zh) 2001-09-05
PT1098871E (pt) 2003-11-28
BR9912291A (pt) 2001-04-17
WO2000005196A1 (en) 2000-02-03
EP1098871A1 (en) 2001-05-16
TR200100166T2 (tr) 2001-05-21
EP1098871B1 (en) 2003-07-09
SK1032001A3 (en) 2001-08-06
HUP0102705A2 (hu) 2001-12-28
ATE244697T1 (de) 2003-07-15
NZ509327A (en) 2003-04-29
CN1183101C (zh) 2005-01-05
KR100599142B1 (ko) 2006-07-12
DE69909486D1 (de) 2003-08-14
KR20010071905A (ko) 2001-07-31
JP2002521358A (ja) 2002-07-16
IL140586A0 (en) 2002-02-10
HUP0102705A3 (en) 2002-11-28
NO20010280L (no) 2001-03-08
CA2337945A1 (en) 2000-02-03
PE20000880A1 (es) 2000-09-12
US6451854B1 (en) 2002-09-17
ES2203163T3 (es) 2004-04-01
DE69909486T2 (de) 2004-05-27
DK1098871T3 (da) 2003-10-27
NO20010280D0 (no) 2001-01-17
ID27261A (id) 2001-03-22
RU2223947C2 (ru) 2004-02-20
PL345621A1 (en) 2002-01-02

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