CO5210883A1 - DERIVADOS DE 4-OXO-3,5-DIHIDRO-4H-PIRIDAZINO [4,5,-b]INDOL- 1-ACETAMIDA - Google Patents

DERIVADOS DE 4-OXO-3,5-DIHIDRO-4H-PIRIDAZINO [4,5,-b]INDOL- 1-ACETAMIDA

Info

Publication number
CO5210883A1
CO5210883A1 CO98043191A CO98043191A CO5210883A1 CO 5210883 A1 CO5210883 A1 CO 5210883A1 CO 98043191 A CO98043191 A CO 98043191A CO 98043191 A CO98043191 A CO 98043191A CO 5210883 A1 CO5210883 A1 CO 5210883A1
Authority
CO
Colombia
Prior art keywords
group
hydrogen
atom
piridazino
dihidro
Prior art date
Application number
CO98043191A
Other languages
English (en)
Inventor
Yannick Evanno
Laurent Dubois
Mireille Sevrin
Frank Marguet
Jacques Froissant
Regine Bartsch
Catherine Gille
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5210883A1 publication Critical patent/CO5210883A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Abstract

Compuesto que corresponde a la fórmula general (I):<EMI FILE="98043191_1" ID="1" IMF=JPEG >En la cual X representa un átomo de hidrógeno o de halógeno o un grupo metilo, metoxi o fenilmetoxi,Y representa un átomo de hidrógeno, 1 o 2 átomos de halógeno o un grupo de hidroxi, metoxi, nitro o metilo,R1 representa un átomo de hidrógeno o de halógeno o un grupo (C1-C4)alquilo,R2 y R3 representan cada uno, independientemente del otro, un átomo de hidrógeno, un grupo (C1-C4)alquilo o un grupo fenilmetilo o bien R2 y R3 forman, con el átomo de nitrógeno que los lleva, un grupo azetidinilo, pirrolidinilo, 3-etoxipirrolidinilo, piperidinilo, morfolinilo, 4, metilpiperazinilo o 1,3-tiazolidinilo.
CO98043191A 1997-07-30 1998-07-29 DERIVADOS DE 4-OXO-3,5-DIHIDRO-4H-PIRIDAZINO [4,5,-b]INDOL- 1-ACETAMIDA CO5210883A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO5210883A1 true CO5210883A1 (es) 2002-10-30

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98043191A CO5210883A1 (es) 1997-07-30 1998-07-29 DERIVADOS DE 4-OXO-3,5-DIHIDRO-4H-PIRIDAZINO [4,5,-b]INDOL- 1-ACETAMIDA

Country Status (33)

Country Link
US (1) US6262045B1 (es)
EP (1) EP1000063B1 (es)
JP (1) JP4322421B2 (es)
KR (1) KR100497782B1 (es)
CN (1) CN1134440C (es)
AR (1) AR013264A1 (es)
AT (1) ATE226584T1 (es)
AU (1) AU736600B2 (es)
BG (1) BG64283B1 (es)
BR (1) BR9811582B1 (es)
CA (1) CA2298522C (es)
CO (1) CO5210883A1 (es)
CZ (1) CZ290011B6 (es)
DE (1) DE69808921T2 (es)
DK (1) DK1000063T3 (es)
EE (1) EE04317B1 (es)
ES (1) ES2186212T3 (es)
FR (1) FR2766823B1 (es)
HK (1) HK1028027A1 (es)
HU (1) HU229430B1 (es)
IL (1) IL133633A (es)
NO (1) NO313963B1 (es)
NZ (1) NZ502361A (es)
PL (1) PL194245B1 (es)
PT (1) PT1000063E (es)
RU (1) RU2197490C2 (es)
SI (1) SI1000063T1 (es)
SK (1) SK283075B6 (es)
TR (1) TR200000278T2 (es)
TW (1) TW506971B (es)
UA (1) UA57088C2 (es)
WO (1) WO1999006406A1 (es)
ZA (1) ZA986786B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
KR20140002810A (ko) * 2005-05-05 2014-01-08 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
SI1924585T1 (sl) * 2005-08-29 2012-09-28 Sanofi Aventis Us Llc Nova kristalinična oblika piridazino (4,5-b) indolnega derivata
CN101272767B (zh) * 2005-08-29 2012-08-29 赛诺菲-安万特美国有限责任公司 7-氯-N,N,5-三甲基-4-氧-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体
JP2009508966A (ja) * 2005-09-23 2009-03-05 シェーリング コーポレイション 治療薬としての縮合四環性ｍＧｌｕＲ１アンタゴニスト
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
MX2011001474A (es) * 2008-08-18 2011-03-25 Sanofi Aventis Llc Proceso para preparar polimorfos.
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EE200000056A (et) 2000-10-16
UA57088C2 (uk) 2003-06-16
ES2186212T3 (es) 2003-05-01
CA2298522A1 (en) 1999-02-11
ATE226584T1 (de) 2002-11-15
TW506971B (en) 2002-10-21
WO1999006406A1 (fr) 1999-02-11
CN1134440C (zh) 2004-01-14
US6262045B1 (en) 2001-07-17
TR200000278T2 (tr) 2000-08-21
SK283075B6 (sk) 2003-02-04
NO20000462L (no) 2000-03-29
FR2766823A1 (fr) 1999-02-05
NZ502361A (en) 2001-06-29
BG104096A (en) 2000-08-31
PT1000063E (pt) 2003-03-31
IL133633A0 (en) 2001-04-30
DE69808921T2 (de) 2003-07-03
FR2766823B1 (fr) 1999-10-08
JP4322421B2 (ja) 2009-09-02
AR013264A1 (es) 2000-12-13
EP1000063A1 (fr) 2000-05-17
BR9811582A (pt) 2000-09-26
HU229430B1 (en) 2013-12-30
NO313963B1 (no) 2003-01-06
AU736600B2 (en) 2001-08-02
BR9811582B1 (pt) 2010-10-19
EE04317B1 (et) 2004-06-15
CZ290011B6 (cs) 2002-05-15
HK1028027A1 (en) 2001-02-02
RU2197490C2 (ru) 2003-01-27
HUP0002650A3 (en) 2002-09-30
SI1000063T1 (en) 2003-04-30
IL133633A (en) 2004-02-08
KR100497782B1 (ko) 2005-06-27
SK1292000A3 (en) 2000-08-14
NO20000462D0 (no) 2000-01-28
HUP0002650A2 (hu) 2001-01-29
PL194245B1 (pl) 2007-05-31
DK1000063T3 (da) 2003-02-24
JP2001512122A (ja) 2001-08-21
CA2298522C (en) 2008-07-15
EP1000063B1 (fr) 2002-10-23
PL338445A1 (en) 2000-11-06
BG64283B1 (bg) 2004-08-31
AU8983298A (en) 1999-02-22
KR20010022356A (ko) 2001-03-15
DE69808921D1 (de) 2002-11-28
CZ2000320A3 (cs) 2000-05-17
CN1265108A (zh) 2000-08-30
ZA986786B (en) 1999-02-02

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Legal Events

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