ES2186212T3 - Compuesto farmaceutico. - Google Patents

Compuesto farmaceutico.

Info

Publication number
ES2186212T3
ES2186212T3 ES98941468T ES98941468T ES2186212T3 ES 2186212 T3 ES2186212 T3 ES 2186212T3 ES 98941468 T ES98941468 T ES 98941468T ES 98941468 T ES98941468 T ES 98941468T ES 2186212 T3 ES2186212 T3 ES 2186212T3
Authority
ES
Spain
Prior art keywords
sub
group
hydrogen atom
methyl
pyrrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98941468T
Other languages
English (en)
Inventor
Yannick Evanno
Laurent Dubois
Mireille Sevrin
Frank Marguet
Jacques Froissant
Regine Bartsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2186212T3 publication Critical patent/ES2186212T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Abstract

La invención se refiere a compuestos de la fórmula general (I) en la que: X representa un átomo de hidrógeno o halógeno o un grupo metilo, metoxi, o fenilmetoxi; Y representa a un átomo de hidrógeno, uno o dos átomos de halógeno o un grupo metilo, hidroxi, metoxi o nitro; R{sub,1} representa un átomo de hidrógeno o un grupo alquilo C{sub,1-4}; R{sub,2} y R{sub,3} representan cada uno, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo C{sub,1-4}, o un grupo fenil-metilo; o R{sub,2} y R{sub,3} forman, junto con el átomo de nitrógeno que les soporta, un grupo azetinil, pirrolidinil, 3-etoxi-pirrolidinil, piperidinil, morfolinil, 4-metilperacinil o 1,3-tiazolidinil. Se pueden emplear para tratamiento de enfermedades relacionadas con los trastornos de transmisión GABAérgicos.
ES98941468T 1997-07-30 1998-07-28 Compuesto farmaceutico. Expired - Lifetime ES2186212T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2186212T3 true ES2186212T3 (es) 2003-05-01

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98941468T Expired - Lifetime ES2186212T3 (es) 1997-07-30 1998-07-28 Compuesto farmaceutico.

Country Status (33)

Country Link
US (1) US6262045B1 (es)
EP (1) EP1000063B1 (es)
JP (1) JP4322421B2 (es)
KR (1) KR100497782B1 (es)
CN (1) CN1134440C (es)
AR (1) AR013264A1 (es)
AT (1) ATE226584T1 (es)
AU (1) AU736600B2 (es)
BG (1) BG64283B1 (es)
BR (1) BR9811582B1 (es)
CA (1) CA2298522C (es)
CO (1) CO5210883A1 (es)
CZ (1) CZ290011B6 (es)
DE (1) DE69808921T2 (es)
DK (1) DK1000063T3 (es)
EE (1) EE04317B1 (es)
ES (1) ES2186212T3 (es)
FR (1) FR2766823B1 (es)
HK (1) HK1028027A1 (es)
HU (1) HU229430B1 (es)
IL (1) IL133633A (es)
NO (1) NO313963B1 (es)
NZ (1) NZ502361A (es)
PL (1) PL194245B1 (es)
PT (1) PT1000063E (es)
RU (1) RU2197490C2 (es)
SI (1) SI1000063T1 (es)
SK (1) SK283075B6 (es)
TR (1) TR200000278T2 (es)
TW (1) TW506971B (es)
UA (1) UA57088C2 (es)
WO (1) WO1999006406A1 (es)
ZA (1) ZA986786B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
KR20080015077A (ko) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
WO2007027525A1 (en) * 2005-08-29 2007-03-08 Sanofi-Aventis U.S. Llc Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
SI1926476T1 (sl) * 2005-08-29 2013-07-31 Sanofi-Aventis U.S. Llc Amorfne trdne disperzije 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5- dihidro-4H-piridazino/4,5-b/indol-1-acetamida
WO2007038209A2 (en) * 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
MX2011001474A (es) * 2008-08-18 2011-03-25 Sanofi Aventis Llc Proceso para preparar polimorfos.
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
SK283075B6 (sk) 2003-02-04
EP1000063A1 (fr) 2000-05-17
NO313963B1 (no) 2003-01-06
PL194245B1 (pl) 2007-05-31
EE200000056A (et) 2000-10-16
RU2197490C2 (ru) 2003-01-27
JP2001512122A (ja) 2001-08-21
HUP0002650A3 (en) 2002-09-30
AU8983298A (en) 1999-02-22
CA2298522A1 (en) 1999-02-11
HU229430B1 (en) 2013-12-30
BG64283B1 (bg) 2004-08-31
KR20010022356A (ko) 2001-03-15
DE69808921D1 (de) 2002-11-28
CN1265108A (zh) 2000-08-30
BR9811582A (pt) 2000-09-26
NZ502361A (en) 2001-06-29
AU736600B2 (en) 2001-08-02
FR2766823B1 (fr) 1999-10-08
NO20000462L (no) 2000-03-29
UA57088C2 (uk) 2003-06-16
DK1000063T3 (da) 2003-02-24
CN1134440C (zh) 2004-01-14
ZA986786B (en) 1999-02-02
PL338445A1 (en) 2000-11-06
SK1292000A3 (en) 2000-08-14
PT1000063E (pt) 2003-03-31
BR9811582B1 (pt) 2010-10-19
EE04317B1 (et) 2004-06-15
IL133633A0 (en) 2001-04-30
SI1000063T1 (en) 2003-04-30
ATE226584T1 (de) 2002-11-15
AR013264A1 (es) 2000-12-13
NO20000462D0 (no) 2000-01-28
BG104096A (en) 2000-08-31
FR2766823A1 (fr) 1999-02-05
EP1000063B1 (fr) 2002-10-23
TW506971B (en) 2002-10-21
TR200000278T2 (tr) 2000-08-21
CZ2000320A3 (cs) 2000-05-17
CZ290011B6 (cs) 2002-05-15
DE69808921T2 (de) 2003-07-03
HUP0002650A2 (hu) 2001-01-29
CA2298522C (en) 2008-07-15
KR100497782B1 (ko) 2005-06-27
HK1028027A1 (en) 2001-02-02
WO1999006406A1 (fr) 1999-02-11
JP4322421B2 (ja) 2009-09-02
CO5210883A1 (es) 2002-10-30
IL133633A (en) 2004-02-08
US6262045B1 (en) 2001-07-17

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