EE04317B1 - 4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks - Google Patents

4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks

Info

Publication number
EE04317B1
EE04317B1 EEP200000056A EEP200000056A EE04317B1 EE 04317 B1 EE04317 B1 EE 04317B1 EE P200000056 A EEP200000056 A EE P200000056A EE P200000056 A EEP200000056 A EE P200000056A EE 04317 B1 EE04317 B1 EE 04317B1
Authority
EE
Estonia
Prior art keywords
pyridazino
ethanamide
indole
dihydro
oxo
Prior art date
Application number
EEP200000056A
Other languages
English (en)
Inventor
Evanno Yannick
Dubois Laurent
Sevrin Mireille
Marguet Frank
Froissant Jacques
Bartsch R�gine
Gille Catherine
Original Assignee
Sanofi-Synthlabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo
Publication of EE200000056A publication Critical patent/EE200000056A/et
Publication of EE04317B1 publication Critical patent/EE04317B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
EEP200000056A 1997-07-30 1998-07-28 4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks EE04317B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR1998/001667 WO1999006406A1 (fr) 1997-07-30 1998-07-28 DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b] INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
EE200000056A EE200000056A (et) 2000-10-16
EE04317B1 true EE04317B1 (et) 2004-06-15

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000056A EE04317B1 (et) 1997-07-30 1998-07-28 4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks

Country Status (33)

Country Link
US (1) US6262045B1 (et)
EP (1) EP1000063B1 (et)
JP (1) JP4322421B2 (et)
KR (1) KR100497782B1 (et)
CN (1) CN1134440C (et)
AR (1) AR013264A1 (et)
AT (1) ATE226584T1 (et)
AU (1) AU736600B2 (et)
BG (1) BG64283B1 (et)
BR (1) BR9811582B1 (et)
CA (1) CA2298522C (et)
CO (1) CO5210883A1 (et)
CZ (1) CZ290011B6 (et)
DE (1) DE69808921T2 (et)
DK (1) DK1000063T3 (et)
EE (1) EE04317B1 (et)
ES (1) ES2186212T3 (et)
FR (1) FR2766823B1 (et)
HK (1) HK1028027A1 (et)
HU (1) HU229430B1 (et)
IL (1) IL133633A (et)
NO (1) NO313963B1 (et)
NZ (1) NZ502361A (et)
PL (1) PL194245B1 (et)
PT (1) PT1000063E (et)
RU (1) RU2197490C2 (et)
SI (1) SI1000063T1 (et)
SK (1) SK283075B6 (et)
TR (1) TR200000278T2 (et)
TW (1) TW506971B (et)
UA (1) UA57088C2 (et)
WO (1) WO1999006406A1 (et)
ZA (1) ZA986786B (et)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
JP5483874B2 (ja) * 2005-05-05 2014-05-07 サノフィ−アベンティス・ユー・エス・エルエルシー 安定なナノ粒子処方物
NZ566313A (en) * 2005-08-29 2011-04-29 Sanofi Aventis Us Llc Amorphous solid dispersions of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4, 5-b]indole-1-acetamide
PT1924585E (pt) * 2005-08-29 2012-01-19 Sanofi Aventis Us Llc Nova forma cristalina de um derivado de piridazino[4,5-b]indole
MX2008004024A (es) * 2005-09-23 2009-02-27 Schering Corp Antagonistas de receptor de glutamato metabotropico-1 tetraciclicos fusionados como agentes terapeuticos.
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
AU2009283039A1 (en) * 2008-08-18 2010-02-25 Sanofi-Aventis U.S. Llc Process for preparing polymorph of 7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4H-pyridazin0[4,5-b]indole-1-acetamide
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP2001512122A (ja) 2001-08-21
BR9811582B1 (pt) 2010-10-19
TR200000278T2 (tr) 2000-08-21
DK1000063T3 (da) 2003-02-24
KR100497782B1 (ko) 2005-06-27
SK1292000A3 (en) 2000-08-14
CA2298522C (en) 2008-07-15
NZ502361A (en) 2001-06-29
PL194245B1 (pl) 2007-05-31
NO20000462D0 (no) 2000-01-28
SI1000063T1 (en) 2003-04-30
IL133633A (en) 2004-02-08
HUP0002650A2 (hu) 2001-01-29
US6262045B1 (en) 2001-07-17
ES2186212T3 (es) 2003-05-01
TW506971B (en) 2002-10-21
ZA986786B (en) 1999-02-02
CA2298522A1 (en) 1999-02-11
HK1028027A1 (en) 2001-02-02
ATE226584T1 (de) 2002-11-15
AR013264A1 (es) 2000-12-13
CN1134440C (zh) 2004-01-14
UA57088C2 (uk) 2003-06-16
SK283075B6 (sk) 2003-02-04
AU8983298A (en) 1999-02-22
CO5210883A1 (es) 2002-10-30
CZ2000320A3 (cs) 2000-05-17
JP4322421B2 (ja) 2009-09-02
DE69808921D1 (de) 2002-11-28
NO313963B1 (no) 2003-01-06
BR9811582A (pt) 2000-09-26
BG104096A (en) 2000-08-31
HU229430B1 (en) 2013-12-30
WO1999006406A1 (fr) 1999-02-11
FR2766823A1 (fr) 1999-02-05
EP1000063B1 (fr) 2002-10-23
AU736600B2 (en) 2001-08-02
KR20010022356A (ko) 2001-03-15
EP1000063A1 (fr) 2000-05-17
FR2766823B1 (fr) 1999-10-08
CZ290011B6 (cs) 2002-05-15
HUP0002650A3 (en) 2002-09-30
PT1000063E (pt) 2003-03-31
DE69808921T2 (de) 2003-07-03
BG64283B1 (bg) 2004-08-31
IL133633A0 (en) 2001-04-30
RU2197490C2 (ru) 2003-01-27
NO20000462L (no) 2000-03-29
PL338445A1 (en) 2000-11-06
CN1265108A (zh) 2000-08-30
EE200000056A (et) 2000-10-16

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

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MM4A Lapsed by not paying the annual fees

Effective date: 20140728