CO6280529A2 - DERIVADOS DE AMIDA AROMÁTICOS DE ÁCIDO PENTANOICO COMO MODULADORES DE γ - SECRETOSA - Google Patents

DERIVADOS DE AMIDA AROMÁTICOS DE ÁCIDO PENTANOICO COMO MODULADORES DE γ - SECRETOSA

Info

Publication number
CO6280529A2
CO6280529A2 CO10048723A CO10048723A CO6280529A2 CO 6280529 A2 CO6280529 A2 CO 6280529A2 CO 10048723 A CO10048723 A CO 10048723A CO 10048723 A CO10048723 A CO 10048723A CO 6280529 A2 CO6280529 A2 CO 6280529A2
Authority
CO
Colombia
Prior art keywords
secretose
modulators
aromatic
pentanoic acid
amida
Prior art date
Application number
CO10048723A
Other languages
English (en)
Inventor
Chih Yung Ho
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6280529A2 publication Critical patent/CO6280529A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a los compuestos de la Fórmula I como se muestran a continuación, en donde las definiciones de A, R1, R2, R3, R4, R5, R6, R7, y R8 se proporcionan en la especificación. Los compuestos de la Fórmula I son útiles para el tratamiento de enfermedades asociadas con la actividad de la ?-secretasa, que incluye la enfermedad de Alzheimer.
CO10048723A 2007-10-19 2010-04-26 DERIVADOS DE AMIDA AROMÁTICOS DE ÁCIDO PENTANOICO COMO MODULADORES DE γ - SECRETOSA CO6280529A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98117007P 2007-10-19 2007-10-19

Publications (1)

Publication Number Publication Date
CO6280529A2 true CO6280529A2 (es) 2011-05-20

Family

ID=40091367

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10048723A CO6280529A2 (es) 2007-10-19 2010-04-26 DERIVADOS DE AMIDA AROMÁTICOS DE ÁCIDO PENTANOICO COMO MODULADORES DE γ - SECRETOSA

Country Status (18)

Country Link
US (1) US7951843B2 (es)
EP (1) EP2212280B1 (es)
JP (1) JP5543353B2 (es)
KR (1) KR20100090265A (es)
CN (1) CN101888990B (es)
AU (1) AU2008312653B2 (es)
BR (1) BRPI0817425A2 (es)
CA (1) CA2702835A1 (es)
CO (1) CO6280529A2 (es)
CR (1) CR11436A (es)
EA (1) EA017907B1 (es)
ES (1) ES2447842T3 (es)
IL (1) IL205044A (es)
MX (1) MX2010004308A (es)
NI (1) NI201000063A (es)
NZ (1) NZ584721A (es)
WO (1) WO2009052079A1 (es)
ZA (1) ZA201003518B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5543354B2 (ja) * 2007-10-19 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ γ−セクレターゼのアミン結合調節物質
EP2215043B1 (en) * 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
EA017119B1 (ru) * 2007-10-19 2012-09-28 Янссен Фармацевтика, Н.В. МОДУЛЯТОРЫ АКТИВНОСТИ γ-СЕКРЕТАЗЫ ИЗ ГРУППЫ ПИПЕРИДИНИЛА И ПИПЕРАЗИНИЛА
WO2011009064A1 (en) * 2009-07-17 2011-01-20 The J. David Gladstone Institutes Methods of controlling cell proliferation
US8871460B2 (en) * 2009-11-09 2014-10-28 Neurogenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
CA2406383A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research A.beta.42 lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
PL1773816T3 (pl) * 2004-06-24 2015-06-30 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą ATP
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
CN101490024A (zh) * 2006-06-09 2009-07-22 Icos股份有限公司 用作dp-2拮抗剂的取代的苯乙酸

Also Published As

Publication number Publication date
JP2011500699A (ja) 2011-01-06
IL205044A0 (en) 2010-11-30
MX2010004308A (es) 2010-05-03
ZA201003518B (en) 2012-07-25
NZ584721A (en) 2011-11-25
US7951843B2 (en) 2011-05-31
AU2008312653A1 (en) 2009-04-23
BRPI0817425A2 (pt) 2015-06-16
KR20100090265A (ko) 2010-08-13
CN101888990A (zh) 2010-11-17
CA2702835A1 (en) 2009-04-23
IL205044A (en) 2015-02-26
JP5543353B2 (ja) 2014-07-09
AU2008312653B2 (en) 2013-03-07
CN101888990B (zh) 2014-01-29
EA017907B1 (ru) 2013-04-30
ES2447842T3 (es) 2014-03-13
US20090105345A1 (en) 2009-04-23
EP2212280A1 (en) 2010-08-04
EP2212280B1 (en) 2013-12-04
NI201000063A (es) 2010-09-13
WO2009052079A1 (en) 2009-04-23
EA201070494A1 (ru) 2010-12-30
CR11436A (es) 2011-01-14

Similar Documents

Publication Publication Date Title
ECSP12011622A (es) Derivados de oxazina y su uso como inhibidores de bace para el tratamiento de trastornos neurológicos
HN2012001413A (es) Derivados de pirazina y su uso en el tratamiento de trastornos neurólogicos
ECSP13012611A (es) Derivados de pirazol-aminopirimidina como moduladores de la lrrk2
NI200700040A (es) Analogos de biaril piperazinil-piridina sustituidos
CU20130082A7 (es) 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
CR10948A (es) Compuestos triciclicos, composiciones y procedimientos
CO6270312A2 (es) Moduladores de gpr40 bifenilo-sustituidos
UY32543A (es) Análogos de isoxazol-3(2h)-ona como agentes terapéuticos
PA8627201A1 (es) Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos
UY35012A (es) Alcoxipirazoles como activadores de guanilato ciclasa soluble
ECSP11010786A (es) 5-alquinil-pirimidinas
UY30377A1 (es) Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa
CO6280529A2 (es) DERIVADOS DE AMIDA AROMÁTICOS DE ÁCIDO PENTANOICO COMO MODULADORES DE γ - SECRETOSA
UY31162A1 (es) Espiroindolinas como moduladores de receptores de quimioquinas
CO6280527A2 (es) Derivados de amina aromáticos de ácido pentanoico como moduladores de gama secretasa
UY33176A (es) Derivados de oxazolopirimidina sustituida en 2, 5, 7.
UY32747A (es) 2-carboxamida-cicloamino-ureas sustituidas
CR11447A (es) Moduladores de piperidinil y piperazinil de y secretasa
ECSP088280A (es) Compuestos de imidazol para el tratamiento de trastornos neurológicos
UY32002A (es) Piridinilo moduladores de gamma-secretasa
UY33181A (es) Derivados de oxazolopirimidina 2,5-sustituidos.
CO6270355A2 (es) Metodo para obtener derivados aromaticos de acido pentanoico con actividad de modulacion de la gamma secretasa
CO6270315A2 (es) Metodo para obtener derivados aromaticos de acido pentanoico con actividad de modulacion de la gamma secretasa
PE20141247A1 (es) 1,4-diazabiciclo[3.2.2]nonanos como ligandos de receptores nicotinicos neuronales de acetilcolina
DOP2004000982A (es) Compuestos para el tratamiento de trastornos neurodegenerativos

Legal Events

Date Code Title Description
FC Application refused