PE20141247A1 - 1,4-diazabiciclo[3.2.2]nonanos como ligandos de receptores nicotinicos neuronales de acetilcolina - Google Patents

1,4-diazabiciclo[3.2.2]nonanos como ligandos de receptores nicotinicos neuronales de acetilcolina

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Publication number
PE20141247A1
PE20141247A1 PE2014000228A PE2014000228A PE20141247A1 PE 20141247 A1 PE20141247 A1 PE 20141247A1 PE 2014000228 A PE2014000228 A PE 2014000228A PE 2014000228 A PE2014000228 A PE 2014000228A PE 20141247 A1 PE20141247 A1 PE 20141247A1
Authority
PE
Peru
Prior art keywords
diazabicycle
acetylcholine receptors
isoxazolo
nonan
ona
Prior art date
Application number
PE2014000228A
Other languages
English (en)
Inventor
Anatoly A Mazurov
Lan Miao
Todd Showalter
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PE20141247A1 publication Critical patent/PE20141247A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 1,4-DIAZABICICLO[3.2.2]NONANOS DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C6), ARILO, ALQUILO(C1-C6) SUSTITUIDO CON ARILO, O R1 Y R2 SE COMBINAN CON LOS ATOMOS DE CARBONO A LOS QUE ESTAN UNIDOS PARA FORMAR UN ANILLO CARBOCICLICO DE 5 O 6 MIEMBROS. SON COMPUESTOS PREFERIDOS: 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-METIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA; 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-ETIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA; 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-BENCIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES NICOTINICOS NEURONALES DE ACETILCOLINA SIENDO UTILES EN EL TRATAMIENTO DE DEMENCIA PRESENIL, ENFERMEDAD DE ALZHEIMER, DEMENCIA DE LOS CUERPOS DE LEWY
PE2014000228A 2011-08-22 2012-08-20 1,4-diazabiciclo[3.2.2]nonanos como ligandos de receptores nicotinicos neuronales de acetilcolina PE20141247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161526181P 2011-08-22 2011-08-22

Publications (1)

Publication Number Publication Date
PE20141247A1 true PE20141247A1 (es) 2014-10-12

Family

ID=46785810

Family Applications (1)

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PE2014000228A PE20141247A1 (es) 2011-08-22 2012-08-20 1,4-diazabiciclo[3.2.2]nonanos como ligandos de receptores nicotinicos neuronales de acetilcolina

Country Status (20)

Country Link
US (1) US20140249141A1 (es)
EP (1) EP2748170A1 (es)
JP (1) JP2014524470A (es)
KR (1) KR20140068079A (es)
CN (1) CN103797016A (es)
AR (1) AR087602A1 (es)
AU (1) AU2012299077A1 (es)
BR (1) BR112014004068A2 (es)
CA (1) CA2844764A1 (es)
CL (1) CL2014000417A1 (es)
CO (1) CO6920290A2 (es)
HK (1) HK1199251A1 (es)
IL (1) IL230889A0 (es)
MX (1) MX2014002005A (es)
PE (1) PE20141247A1 (es)
RU (1) RU2014110971A (es)
SG (1) SG2014011126A (es)
TW (1) TW201311698A (es)
UY (1) UY34281A (es)
WO (1) WO2013028587A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127000A1 (en) * 2015-02-04 2016-08-11 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules
CN117402117B (zh) * 2023-12-15 2024-03-19 南京威凯尔生物医药科技有限公司 一种4-嘧啶酮衍生物的制备方法

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Also Published As

Publication number Publication date
BR112014004068A2 (pt) 2017-03-14
WO2013028587A1 (en) 2013-02-28
US20140249141A1 (en) 2014-09-04
IL230889A0 (en) 2014-03-31
CO6920290A2 (es) 2014-04-10
SG2014011126A (en) 2014-06-27
EP2748170A1 (en) 2014-07-02
MX2014002005A (es) 2014-03-27
KR20140068079A (ko) 2014-06-05
UY34281A (es) 2014-02-28
TW201311698A (zh) 2013-03-16
HK1199251A1 (en) 2015-06-26
CL2014000417A1 (es) 2014-09-26
CA2844764A1 (en) 2013-02-28
RU2014110971A (ru) 2015-09-27
CN103797016A (zh) 2014-05-14
AR087602A1 (es) 2014-04-03
AU2012299077A1 (en) 2014-03-13
JP2014524470A (ja) 2014-09-22

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