NI201000066A - AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA. - Google Patents
AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA.Info
- Publication number
- NI201000066A NI201000066A NI201000066A NI201000066A NI201000066A NI 201000066 A NI201000066 A NI 201000066A NI 201000066 A NI201000066 A NI 201000066A NI 201000066 A NI201000066 A NI 201000066A NI 201000066 A NI201000066 A NI 201000066A
- Authority
- NI
- Nicaragua
- Prior art keywords
- secretase modulators
- amines attached
- amines
- attached
- compounds
- Prior art date
Links
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical group C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente invención se relaciona compuestos de la Fórmula I como se muestra abajo, en donde las definiciones de A, X, Y, R1, R2, R3, R4, R5, R6, R7, R8 y R9 se proporcionan en la especificación. Los compuestos de la Fórmula I son útiles para el tratamiento de enfermedades asociadas con la actividad de la y-secretasa, incluyendo la enfermedad de Alzheimer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98129307P | 2007-10-19 | 2007-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000066A true NI201000066A (es) | 2010-09-13 |
Family
ID=40090406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000066A NI201000066A (es) | 2007-10-19 | 2010-04-16 | AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8247610B2 (es) |
EP (1) | EP2212277B1 (es) |
JP (1) | JP5543354B2 (es) |
KR (1) | KR20100082351A (es) |
CN (1) | CN101903335A (es) |
AU (1) | AU2008312371B2 (es) |
BR (1) | BRPI0817837A2 (es) |
CA (1) | CA2703636A1 (es) |
CO (1) | CO6270315A2 (es) |
CR (1) | CR11450A (es) |
EA (1) | EA018862B1 (es) |
IL (1) | IL205041A (es) |
MX (1) | MX2010004318A (es) |
NI (1) | NI201000066A (es) |
WO (1) | WO2009052350A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2212287B1 (en) * | 2007-10-19 | 2012-02-01 | Janssen Pharmaceutica, N.V. | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE |
KR101618068B1 (ko) * | 2007-10-19 | 2016-05-04 | 얀센 파마슈티카 엔.브이. | γ-세크레타아제의 탄소 결합된 조절제 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790287A (fr) | 1971-10-28 | 1973-04-19 | Delalande Sa | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique |
BE826017R (fr) * | 1974-03-19 | 1975-08-26 | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique | |
US4252951A (en) | 1979-10-09 | 1981-02-24 | Eli Lilly And Company | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
US5391817A (en) | 1993-12-21 | 1995-02-21 | Bristol-Myers Squibb | Biaryl phospholipase A2 inhibitors |
US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
EP1284729A4 (en) * | 2000-04-13 | 2007-12-19 | Mayo Foundation | REDUCTION AGENTS OF A (BETA) 42 |
DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
US20080313061A1 (en) | 2004-06-30 | 2008-12-18 | Paysetter Pte Ltd | System and Method for Facilitating Transfer of Physical Money and/or Credit |
DE102004033876B4 (de) | 2004-07-13 | 2009-01-15 | Christoph Kaesbohrer | Dreidimensionales Struktursystem |
GB0416508D0 (en) * | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
PT1849762E (pt) * | 2006-04-21 | 2009-09-16 | Cellzome Ltd | Ácidos bifenilcarboxílicos substituídos e seus derivados |
DK1847524T3 (da) | 2006-04-21 | 2010-01-11 | Cellzome Ltd | Terphenylderivater til behandling af Alzheimers sygdom |
AU2007257841A1 (en) | 2006-06-09 | 2007-12-21 | Icos Corporation | Substituted phenyl acetic acids as DP-2 antagonists |
EP2044044A2 (en) * | 2006-06-09 | 2009-04-08 | Icos Corporation | Substituted phenyl acetic acids as dp-2 antagonists |
CN101861297B (zh) | 2007-10-17 | 2014-04-23 | 詹森药业有限公司 | 联苯羧酸及其衍生物 |
EP2212287B1 (en) | 2007-10-19 | 2012-02-01 | Janssen Pharmaceutica, N.V. | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE |
US20090306392A1 (en) | 2007-10-19 | 2009-12-10 | Chih Yung Ho | Gsm intermediates |
KR101618068B1 (ko) | 2007-10-19 | 2016-05-04 | 얀센 파마슈티카 엔.브이. | γ-세크레타아제의 탄소 결합된 조절제 |
JP5543353B2 (ja) | 2007-10-19 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | γ−セクレターゼのアミド結合調節物質 |
US7968725B2 (en) | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
-
2008
- 2008-10-17 EP EP08839840.9A patent/EP2212277B1/en active Active
- 2008-10-17 AU AU2008312371A patent/AU2008312371B2/en not_active Ceased
- 2008-10-17 CN CN2008801215605A patent/CN101903335A/zh active Pending
- 2008-10-17 CA CA2703636A patent/CA2703636A1/en not_active Abandoned
- 2008-10-17 BR BRPI0817837-2A patent/BRPI0817837A2/pt not_active IP Right Cessation
- 2008-10-17 WO PCT/US2008/080270 patent/WO2009052350A1/en active Application Filing
- 2008-10-17 EA EA201070498A patent/EA018862B1/ru not_active IP Right Cessation
- 2008-10-17 KR KR1020107010872A patent/KR20100082351A/ko active IP Right Grant
- 2008-10-17 MX MX2010004318A patent/MX2010004318A/es active IP Right Grant
- 2008-10-17 US US12/253,444 patent/US8247610B2/en not_active Expired - Fee Related
- 2008-10-17 JP JP2010530134A patent/JP5543354B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-13 IL IL205041A patent/IL205041A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000066A patent/NI201000066A/es unknown
- 2010-04-30 CO CO10051584A patent/CO6270315A2/es not_active Application Discontinuation
- 2010-05-19 CR CR11450A patent/CR11450A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20090105300A1 (en) | 2009-04-23 |
IL205041A0 (en) | 2010-11-30 |
BRPI0817837A2 (pt) | 2015-04-07 |
KR20100082351A (ko) | 2010-07-16 |
WO2009052350A1 (en) | 2009-04-23 |
EP2212277B1 (en) | 2016-08-31 |
EP2212277A1 (en) | 2010-08-04 |
CA2703636A1 (en) | 2009-04-23 |
EA201070498A1 (ru) | 2010-10-29 |
IL205041A (en) | 2015-01-29 |
MX2010004318A (es) | 2010-04-30 |
AU2008312371B2 (en) | 2013-06-20 |
US8247610B2 (en) | 2012-08-21 |
AU2008312371A1 (en) | 2009-04-23 |
EA018862B1 (ru) | 2013-11-29 |
CO6270315A2 (es) | 2011-04-20 |
CN101903335A (zh) | 2010-12-01 |
JP5543354B2 (ja) | 2014-07-09 |
JP2011500722A (ja) | 2011-01-06 |
CR11450A (es) | 2011-01-14 |
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