TR201816176T4 - Histon deasetilaz 6 inhibitörleri olarak yeni bileşikler ve bunu içeren farmasötik bileşimler. - Google Patents
Histon deasetilaz 6 inhibitörleri olarak yeni bileşikler ve bunu içeren farmasötik bileşimler. Download PDFInfo
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- TR201816176T4 TR201816176T4 TR2018/16176T TR201816176T TR201816176T4 TR 201816176 T4 TR201816176 T4 TR 201816176T4 TR 2018/16176 T TR2018/16176 T TR 2018/16176T TR 201816176 T TR201816176 T TR 201816176T TR 201816176 T4 TR201816176 T4 TR 201816176T4
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- novel compounds
- histone deacetylase
- pharmaceutical compositions
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- 102000011427 Histone Deacetylase 6 Human genes 0.000 title abstract 6
- 108010023925 Histone Deacetylase 6 Proteins 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Mevcut buluş histon deasetilaz 6 (HDAC6) inhibitör aktivitesine sahip yeni bileşikler, bunun izomerleri veya bunun farmasötik olarak kabul edilebilir tuzları, terapötik tıbbi ilaçların hazırlanışına yönelik bunun kullanımı, bunu içeren farmasötik bileşimler, bileşim kullanılarak hastalık tedavi edilmesinin bir yöntemi ve yeni bileşiklerin hazırlanmasına yönelik yöntemler ile ilgilidir. Mevcut buluşa göre yeni bileşikler histon deasetilaz 6 (HDAC6) inhibitör aktivitesine sahiptir ve kanser, inflamatuar hastalıklar, otoimmün hastalıklar, nörolojik hastalıklar ve nörodejeneratif bozukluklar dahil HDAC6-ilişkili hastalıkların önlenmesi veya tedavisine yönelik etkilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140028920 | 2014-03-12 |
Publications (1)
Publication Number | Publication Date |
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TR201816176T4 true TR201816176T4 (tr) | 2018-11-21 |
Family
ID=54072109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/16176T TR201816176T4 (tr) | 2014-03-12 | 2015-03-12 | Histon deasetilaz 6 inhibitörleri olarak yeni bileşikler ve bunu içeren farmasötik bileşimler. |
Country Status (19)
Country | Link |
---|---|
US (1) | US10287255B2 (tr) |
EP (1) | EP3116859B1 (tr) |
JP (1) | JP6392888B2 (tr) |
KR (1) | KR101697518B1 (tr) |
CN (1) | CN106232584B (tr) |
AU (1) | AU2015230127B2 (tr) |
CA (1) | CA2941581C (tr) |
DK (1) | DK3116859T3 (tr) |
ES (1) | ES2694053T3 (tr) |
HR (1) | HRP20181534T1 (tr) |
MX (1) | MX2016011833A (tr) |
MY (1) | MY177631A (tr) |
NZ (1) | NZ724030A (tr) |
PH (1) | PH12016501735B1 (tr) |
PL (1) | PL3116859T3 (tr) |
PT (1) | PT3116859T (tr) |
RU (1) | RU2660897C2 (tr) |
TR (1) | TR201816176T4 (tr) |
WO (1) | WO2015137750A1 (tr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10112915B2 (en) | 2015-02-02 | 2018-10-30 | Forma Therapeutics, Inc. | 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
TW201636329A (zh) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | 作為hdac抑制劑之雙環[4,6,0]異羥肟酸 |
US11420950B2 (en) | 2015-05-22 | 2022-08-23 | Chong Kun Dang Pharmaceutical Corp. | Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same |
KR20180098593A (ko) * | 2015-12-22 | 2018-09-04 | 칸세라 아베 | 포유류의 히스톤 탈아세틸화효소 활성에 대한 저해제로서 유용한 바이사이클릭 하이드록사믹산 |
US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
EP3538084B1 (en) | 2016-11-10 | 2023-11-01 | Acetylon Pharmaceuticals, Inc. | Phenyl and pyridinyl hydroxamic acids |
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
KR102078528B1 (ko) * | 2018-04-18 | 2020-02-19 | 성균관대학교산학협력단 | 신규한 hdac6 억제제를 이용한 치매 또는 인지장애 예방 또는 치료용 약학적 조성물 |
CN110511173B (zh) * | 2018-05-22 | 2023-06-23 | 复旦大学 | 一种吲哚烷基哌嗪苯甲酰胺类化合物及其应用 |
KR20200061310A (ko) | 2018-11-23 | 2020-06-02 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제를 포함하는 약학적 조성물 |
CN111320577B (zh) * | 2018-12-13 | 2023-06-23 | 广东东阳光药业有限公司 | 一种吡啶酰胺的制备方法及其应用 |
KR20220100860A (ko) * | 2019-09-17 | 2022-07-18 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 질병의 치료에 사용하기 위한 치환된, 포화 및 불포화 n-헤테로시클릭 카르복사미드 및 관련 화합물 |
TW202126643A (zh) | 2019-09-27 | 2021-07-16 | 日商武田藥品工業股份有限公司 | 雜環化合物 |
IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
EP4333841A1 (en) | 2021-05-04 | 2024-03-13 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
CN116120261B (zh) * | 2022-11-30 | 2024-01-23 | 浙大宁波理工学院 | 一种3-[(4-磺胺哌嗪-1-基)甲基]苯甲酸类化合物的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001062742A1 (en) | 2000-02-21 | 2001-08-30 | Astrazeneca Ab | Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases |
US6784173B2 (en) * | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
OA12790A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase. |
CN101450934B (zh) | 2002-03-13 | 2012-10-10 | 詹森药业有限公司 | 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物 |
JP4606027B2 (ja) * | 2002-04-03 | 2011-01-05 | トポターゲット ユーケー リミテッド | Hdac阻害剤としてのピペラジン結合を有するカルバミン酸化合物 |
JP2007509930A (ja) * | 2003-10-27 | 2007-04-19 | エス*バイオ プライベート リミティッド | アシル尿素およびスルホニル尿素が結合したヒドロキサマート |
US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
EP2133334A1 (en) * | 2008-06-09 | 2009-12-16 | DAC S.r.l. | Heterocyclic derivatives as HDAC inhibitors |
US8431538B2 (en) | 2009-07-22 | 2013-04-30 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods of using same |
JP2013517281A (ja) * | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッド | 化合物及び方法 |
EP2526093B1 (en) | 2010-01-22 | 2016-08-17 | Acetylon Pharmaceuticals, Inc. | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
CA2825599C (en) | 2011-02-01 | 2021-07-13 | The Board Of Trustees Of The University Of Illinois | 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors |
WO2013041407A1 (en) | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
WO2013052110A1 (en) | 2011-10-03 | 2013-04-11 | The Trustees Of Columbia University In The City Of New York | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
CA2866707A1 (en) | 2012-03-07 | 2013-09-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
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2015
- 2015-03-12 KR KR1020150034556A patent/KR101697518B1/ko active IP Right Grant
- 2015-03-12 PT PT15762410T patent/PT3116859T/pt unknown
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- 2015-03-12 US US15/125,256 patent/US10287255B2/en active Active
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- 2015-03-12 PL PL15762410T patent/PL3116859T3/pl unknown
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- 2015-03-12 ES ES15762410T patent/ES2694053T3/es active Active
- 2015-03-12 CN CN201580020544.7A patent/CN106232584B/zh active Active
- 2015-03-12 JP JP2016557008A patent/JP6392888B2/ja active Active
- 2015-03-12 RU RU2016139690A patent/RU2660897C2/ru active
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- 2016-09-05 PH PH12016501735A patent/PH12016501735B1/en unknown
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Also Published As
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AU2015230127B2 (en) | 2017-04-20 |
WO2015137750A1 (en) | 2015-09-17 |
KR20150106857A (ko) | 2015-09-22 |
US20170096405A1 (en) | 2017-04-06 |
NZ724030A (en) | 2017-09-29 |
US10287255B2 (en) | 2019-05-14 |
JP6392888B2 (ja) | 2018-09-19 |
EP3116859B1 (en) | 2018-08-01 |
CA2941581A1 (en) | 2015-09-17 |
CN106232584B (zh) | 2019-06-28 |
PT3116859T (pt) | 2018-11-15 |
EP3116859A1 (en) | 2017-01-18 |
ES2694053T3 (es) | 2018-12-17 |
MX2016011833A (es) | 2017-03-29 |
PH12016501735A1 (en) | 2017-02-06 |
MY177631A (en) | 2020-09-23 |
RU2016139690A (ru) | 2018-04-16 |
DK3116859T3 (en) | 2018-11-26 |
PL3116859T3 (pl) | 2019-04-30 |
RU2660897C2 (ru) | 2018-07-11 |
CN106232584A (zh) | 2016-12-14 |
HRP20181534T1 (hr) | 2019-01-11 |
PH12016501735B1 (en) | 2017-02-06 |
AU2015230127A1 (en) | 2016-09-22 |
JP2017507976A (ja) | 2017-03-23 |
EP3116859A4 (en) | 2017-02-08 |
KR101697518B1 (ko) | 2017-01-19 |
CA2941581C (en) | 2018-07-24 |
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